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Biomedical subjects

S P Shanor

Publications and source records attributed to S P Shanor.

13 recordsLinked to original sources
PubMed1982

Pepper sauce toxicity.

An acute oral LD50 of Pepper Sauce in male white Sprague-Dawley rats was determined to be 23.58 ml/kg with upper and lower limits of 29.75 and 18.70 ml/kg, respectively, at the 0.95 confidence level. In the female rats, the LD50 was determined to be 19.52 ml/kg with upper and lower limits of 24.35 and 15.64 ml/kg, respectively, at the 0.95 confidence level. This sex variation was found to be insignificant. A subchronic oral toxicity evaluation of Pepper Sauce in male and female white Sprague-Dawley rats revealed no gross or microscopic pathological changes in the animals nor were any significant biochemical changes noted. The growth rates remained within normal range. Pepper Sauce was shown to be a mild skin irritant and a moderate to severe eye irritant in New Zealand albino rabbits; vinegar, an ingredient of Pepper Sauce, was shown to contribute significantly to the ocular toxicity. The Pepper Sauce did not induce terata in Sprague-Dawley rats nor skin sensitization in guinea pigs.

Acetates↗
PubMed1978

Toxicology of poinsettia.

1. The acute oral LD50 of poinsettia in Sprague Dawley rats were greater than 25 gm/kg for all plant parts tested. 2. Exaggerated oral dosing over a five-day period with as much as 125 gm/kg total dose did not produce any gross or microscopic pathology in Sprague Dawley rats. 3. A five-day total diet study of poinsettia produced no gross pathology in Sprague Dawley rats. 4. Poinsettia latex induced no local toxicity when instilled into the buccal cavity of Sprague Dawley rats. 5. Poinsettia latex induced no damage when instilled into the eyes of albino rabbits. 6. Upon repeated exposures poinsettia exhibited mild skin irritation in the albino rabbit. It is not considered to be a primary irritant. 7. Poinsettia induced skin photosensitivity in albino rabbits.

Animals↗
PubMed1978

Acute and subacute toxicology and safety evaluation of triphenyl tin hydroxide (Vancide KS).

The acute oral LD50 in Sprague-Dawley rats was determined to be 171 mg/kg (100-295) for males and 268 mg/kg (205-344) for females. 2. A 1 ppm dietary supplement of Vancide KS for 90 days did not induce any abnormalities in weanling Sprague-Dawley rats. The parameters evaluated were serum glutamic-oxaloacetic transaminase (SGOT), hematocrit, differential white blood cell count, food consumption, and weight gain, along with histologic studies of the myocardium, spleen, liver, kidney, stomach, and small intestine. A 500 ppm diet was lethal. Weanling and older rats subjected to 1000 and 10,000 ppm diets died within 5 days. 3. Vancide KS induced no acute dermal toxicity, nor did it exhibit percutaneous absorption in New Zealand strain albino rabbits. 4. Vancide KS induced no chronic dermal toxicity in New Zealand strain albino rabbits. 5. Vancide KS was not shown to be teratogenic. It exhibited an antifertility action, especially in Sprague-Dawley rats dosed on day 1 through day 7 of timed-pregnancy. 6. Vancide KS was shown to be an eye irritant which induces corneal opacity. 7. Acute oral toxicity studies in Sprague-Dawley rats indicate that Vancide KS should be classified as a toxic substance as defined in the regulations under the Federal Hazardous Labeling Act. 8. The intravenous administration of 25 mg/kg of Vancide KS to New Zealand strain albino rabbits induced death preceded by topic convulsions. 9. Vancide KS did not induce skin sensitization in male adult guinea pigs.

Administration, Oral↗
PubMed1978

Ethylene and diethylene glycol toxicity.

1. Blood concentrations of ethylene and diethylene glycol were evaluated in Sprague-Dawley rats at varying intervals following oral dosages of the glycols. 2. Ethylene and diethylene glycol in rat blood stored under refrigeration at 4 degrees +/- 10 degrees C for a period of 30 days exhibited minimal concentration losses, contrary to previous reports. 3. The amount of oxalate in the blood and kidneys of Sprague-Dawley rats doses with ethylene and diethylene glycol was quantitated. The animals dosed with ethylene glycol demonstrated significantly higher oxalate levels, particularly at 8 hr post-dosing, than similar animals dosed with diethylene glycol. 4. Ethylene glycol induced oxalate deposition within the kidney without significant histologic changes. Diethylene glycol induced histologic changes within the kidneys without kidney oxalate deposition. 5. Maximal kidney oxalate levels, following ethylene glycol dosage, occurred concurrently with peak blood oxalate concentrations. In the case of diethylene glycol, kidney oxalate levels did not peak until 4 hr after maximal blood oxalate levels. 6. Ethylene and diethylene glycol induced different modes of death in Sprague-Dawley rats.

Animals↗
PubMed1977

Methapyrilene toxicity.

Seven cases of drug overdosage involving methapyrilene have been presented, five of which resulted in death. Methapyrilene blood levels ranged fron 1.2 to 3.0 mg% (Table 2). Five of the seven cases involved multiple drug dosage with ethanol, salicylamide, amobarbital, secobarbital, and/or scopolamine. Of the remaining cases, involving only methapyrilene, ome fatality occurred at a blood level of 2.7 mg%. The surviving case involved the reported ingestion of 100 tablets of Sleep-eze (2.5 gm methapyrilene), wherein serial lavage removed 1.1 gm of methapyrilene. Urinalysis revealed 2.52 mg% of methapyrilene in 1300 ml of urine. The methapyrilene blood level was too low to quantitate.

Adult↗
PubMedDate not supplied

Acute and subacute toxicology and safety evaluation of hexahydro-1,3,5-triethyl-S-triazine.

Acute and subacute toxicology and safety evaluation was determined for hexahydro-1,3,5-triethyl-s-triazine (Vancide-TH), a bacteriostatic and fungiastatic agent proposed for industrial use by R. T. Vanderbilt and Co., Inc. Single dose oral toxicity, subacute 14 day dermal toxicity and eye irritation studies were conducted on either the rat or the rabbit. The data obtained indicate that Vancide-TH should be classified as a "toxic, corrosive and an eye-irritating" substance as defined under the "Regulations" of the Federal Hazardous Substances Act. Since the acute dermal LD50 closely approximated the acute oral LD50 in rats, this route might constitute the most serious hazard involved with V-TH and special precautions should be exercised when handling or using this substance. Because of the severe eye-irritating action, precautions should be taken to protect the eyes when handling or using the compound; the ocular damage produced may be irreversible. The "in use" concentrations (1,000 to 10,000 ppm) produced a much lesser toxocity in animals and could be without hazard if precautions are taken.

Animals↗