Topical application of bichloroacetic acid.
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Administration, Topical↗
Biomedical subjects
S P Stone
Publications and source records attributed to S P Stone.
Measuring visual neglect in acute stroke and predicting its recovery: the visual neglect recovery index.
An overall measure of the recovery of visual neglect in patients with an acute stroke is described: The "Visual Neglect Recovery Inde" (VNRI) expresses the amount of visual neglect on a battery of visual neglect tests as a percentage of complete recovery from the maximal visual neglect measurable. The principles underlying the development of the index are similar to those involved in the development of the Motricity Index for hemiplegia. A population of 68 survivors of stroke who presented with visual neglect at two to three days were followed for up to six months. The VNRI showed that neglect was greater in those with right hemisphere stroke than in those with left hemisphere stroke and that recovery was most rapid over the first 10 days and reached a plateau at three months. Most patients, including many with severe initial visual neglect, showed little visual neglect at three months. Stepwise regression analysis showed that the severity of visual neglect at three months and at six months post-stroke could be predicted by the severity of visual neglect and the presence of anosognosia at two to three days. A regression equation was produced which may enable clinicians to select patients for intensive treatment of visual neglect.
Acute Disease↗
Performance of age-matched controls on a battery of visuo-spatial neglect tests.
Examination of 47 independent elderly subjects, matched with a population of patients with acute stroke, found that 55% made at least one omission on a battery of neglect tests. Up to 43% made omissions on any one test. Increasing age and other evidence of cognitive impairment were associated with impaired performance on the battery. Omissions were attributed to an age-related decline in visuo-spatial function. Cut-off points are provided to distinguish between such age-related impairment and visuospatial neglect. The importance of age-matched control studies in developing tests of cognitive impairment in stroke research is highlighted.
Adult↗
The assessment of visuo-spatial neglect after acute stroke.
Forty four consecutive patients with acute hemispheric stroke and forty seven elderly controls with no neurological disease were assessed for visuo-spatial neglect, using a modified neglect test battery. Neglect was found to be equally common in patients with right hemisphere and left hemisphere stroke three days after stroke (72% versus 62%). It was more severe in those with a right hemisphere stroke and resolved more frequently in those with a left hemisphere stroke. The battery was validated against an occupational therapist's assessment of neglect on self-care tasks. The inter-observer reliability was good and it was possible to monitor changes over time with the battery.
Activities of Daily Living↗
Long-term safety of tetracycline.
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Female↗
Basal cell nevus syndrome and adenocarcinoma of the colon. Response to systemic fluorouracil.
A patient with basal nervus syndrome was found to have an adenocarcinoma of the colon. This association, probably fortuitous, made it possible to study the effect of intravenous 5-fluorouracil on the cutaneous basal cell tumors. There was no reaction to this treatment. Subsequently, all visible basal cell tumors were satisfactorily eradicated with topical 5-fluorouracil.
Adenocarcinoma↗
Electrodesiccation and fulguration of lesions of the skin.
Electrosurgery--electrodesiccation, fulguration, and electrocoagulation--is a simple and relatively inexpensive modality for treatment of small skin lesions, whether benign or malignant. The technique is easily mastered, and the results, with proper selection of patients, compare favorably with the results of scalpel-and-suture surgery. Electrosurgery does not mean "burning off" lesions and biopsy of the lesion is an integral part of the technique.
Basal Cell Carcinoma↗
Dapsone-induced jaundice.
Enthusiasm in the use of dapsome for acne conglobata and other severe acne has created an increase in the use of this drug by dermatologists. We describe three patients in whom jaundice developed during dapsome therapy of 3 to 36 weeks' duration. Jaundice was due to cholestasis in two cases and to hemolysis in the third. These significant side effects call for careful observation by the physician if dapsone is to be used with safety.
Adolescent↗
Atopic dermatitis and IgE. Relationship between changes in IgE levels and severity of disease.
At the Mayo Clinic, atopic dermatitis was evaluated in a series of 28 patients to determine whether, during the course of the disease, serum IgE levels fluctuated with changes in the severity of dermatitis. The study covered a 1- to 11/2-year follow-up period. Previously, it had been shown that, at initial examination, serum IgE levels were positively related to the extent of disease. Although notable fluctuations in serum IgE levels and in extent of dermatitis were seen in more than half of the cases, no relationship was found between the two factors during the period of study.
Dermatitis, Atopic↗
Letter: Delayed blanch in alopecia mucinosa.
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Acetylcholine↗
Cutaneous clues to cancer.
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Acanthosis Nigricans↗
Urticaria.
Urticaria is a problem often as vexing to the physician as to the patient. The approach to the patient with hives first demands a search for the etiology, whether endogenous and triggered by emotions or occult systemic disease, exogenous and triggered by allergy to inhaled or ingested antigens, or physical and due to abnormal sensitivity to heat, cold, light, or pressure. Often a fruitless search, the diagnostic evaluation must be accompanied by appropriate symptomatic therapy requiring familiarity with the antihistamines and their relative advantages in the various forms of urticaria. Elimination diets are of diagnostic as well as therapeutic value: pencillin-free, yeast-free, and salicylate-free diets are particularly useful. Therapeutic trials of tetracycline, nystatin and griseofulvin may be helpful, while corticosteroids and specific desensitization are rarely of value.
Histamine H1 Antagonists↗
Bullous pemphigoid and associated malignant neoplasms.
To evaluate the significance of the association of systemic malignant disease with bullous pemphigoid, we reviewed the records of patients with bullous pemphigold seen at the Mayo Clinic between 1960 and 1972. Data from 73 patients with bullous pemphigoid were compared with data from 146 controls (73 with contact dermatitis and 73 with psoriasis) matched for age, sex, and calendar year of diagnosis. In the three groups, eight patients with bullous pemphigoid, 11 with contact dermatitis, and ten with psoriasis were found to have malignant disease within the period covering the five years before and five years after the diagnosis of the skin disease. These data indicate that pemphigoid does not seem to be significantly associated with malignant disease.
Adult↗