PubMed Health⌕ Search

Biomedical subjects

S Pande

Publications and source records attributed to S Pande.

45 records · Page 3Linked to original sources
PubMedDate not supplied

Preparation, characterization and performance evaluation of neomycin-HSA microspheres.

Human serum albumin microspheres containing neomycin sulphate were prepared using emulsion polymerization and polymer dispersion techniques. The many variables which may affect the shape, size, stability, release of the drug from the microspheres such as internal phase to external phase volume ratio, human serum albumin content, stirring rate, polymer content and stabilizing agent concentration, were studied. Unlike the microspheres prepared by the emulsion polymerization technique, polymer dispersion stabilised microspheres were uniform in size and shape with a narrow range of size distribution. In vitro release of neomycin sulphate from albumin microspheres was studied using the dialysis cell method. The drug release from microspheres followed Q versus (t)-1/2 linear relationship. The in vivo distribution studies on prepared microspheres revealed that the localization takes place preferably in lung tissues, liver, spleen and kidney and is found to be dependent on the microsphere size. On administration of microspheres of 3-6 microns size, approximately 55 per cent of administered drug could be localized in the lungs.

Animals↗
PubMedDate not supplied

Localized rifampicin albumin microspheres.

Rifampicin bearing albumin microspheres were prepared. The process variables which could affect the physical characteristics and in vitro release of the drug from the microspheres were optimized. Changes in the original size of the microspheres, namely swelling on exposure to buffer solution pH 7.2 and serum, were monitored. In vivo distribution studies on prepared microspheres revealed that 62 per cent of the drug could be localized in the lungs by controlling microsphere size. Hence, rifampicin bearing albumin microspheres can behave as a reservoir to build up higher local drug concentrations.

Animals↗
PubMedDate not supplied

Enteric spherules diastase in enzyme preparations.

Enteric diastase spherules were prepared using cellulose acetate phthalate and eudragit RS-100 by emulsion solvent removal method. Factors that could affect the size shape and diastatic activity were studied. The studied factors include pH of aqueous media, temperature of dispersion media and concentration of surface active agent. Prepared enteric diastase spherules were investigated for stability and diastatic activity at different temperatures and pH in various buffer systems, in the presence and absence of pepsin, a gastric enzyme. Eudragit RS-100 based spherules were noted to be spherical and uniform in shape with an appreciable level of diastatic activity. However, diastase was observed to be released from such a system in a slow but controlled manner. Eudragit RS-100 was found to provide more stabilization to the diastase than the stabilization provided by cellulose acetate phthalate. The spherules when tested in in vitro and in situ were recorded to exhibit diastatic activity at 99 per cent potency level (based on an actually incorporated amount of diastase). The study reveals that enteric or pH sensitive diastase releasing systems hold promise and potential in the therapeutic application of digestive enzyme(s).

Acrylic Resins↗
PubMedDate not supplied

B-Lynch brace suture simple surgical technique for managing post-partum haemorrhage - report of three cases.

Post-partum haemorrhage is a major contributor to maternal morbidity and mortality. Numerous medical and surgical therapies have been used but none has been uniformly successful. Three cases which were managed successfully with brace suture following failure of medical management for post-partum haemorrhage are being presented. The ease and usefulness of this procedure as a life saving measure, its relative safety and its capacity for preserving the uterus and thus fertility is high lighted.

Adult↗