Biomedical subjects

S Papatheodorou

Publications and source records attributed to S Papatheodorou.

3 recordsLinked to original sources

PubMed2000

Dose calculation and verification of intensity modulation generated by dynamic multileaf collimators.

While the development of inverse planning tools for optimizing dose distributions has come to a level of maturity, intensity modulation has not yet been widely implemented in clinical use because of problems related to its practical delivery and a lack of verification tools and quality assurance (QA) procedures. One of the prerequisites is a dose calculation algorithm that achieves good accuracy. The purpose of this work was twofold. A primary-scatter separation dose model has been extended to account for intensity modulation generated by a dynamic multileaf collimator (MLC). Then the calculation procedures have been tested by comparison with carefully carried out experiments. Intensity modulation is being accounted for by means of a 2D (two-dimensional) matrix of correction factors that modifies the spatial fluence distribution, incident to the patient. The dose calculation for the corresponding open field is then affected by those correction factors. They are used in order to weight separately the primary and the scatter component of the dose at a given point. In order to verify that the calculated dose distributions are in good agreement with measurements on our machine, we have designed a set of test intensity distributions and performed measurements with 6 and 20 MV photons on a Varian Clinac 2300C/D linear accelerator equipped with a 40 leaf pair dynamic MLC. Comparison between calculated and measured dose distributions for a number of representative cases shows, in general, good agreement (within 3% of the normalization in low dose gradient regions and within 3 mm distance-to-dose in high dose gradient regions). For absolute dose calculations (monitor unit calculations), comparison between calculation and measurement reveals good agreement (within 2%) for all tested cases (with the condition that the prescription point is not located on a high dose gradient region).

Algorithms↗

PubMed1999

The 'equivalent wedge' implementation of the Varian Enhanced Dynamic Wedge (EDW) into a treatment planning system.

The purpose of this work was to establish procedures for the implementation of the Varian Enhanced Dynamic Wedge into a treatment planning system (TPS), based as much as possible on simple theoretical considerations and already available data. A method is presented for the calculation (rather than measurement) of off-axis relative wedge transmission curves that are required by the TPS for relative dose calculations. We also present a method for absolute dose (monitor unit) calculations, based on the calculation of an effective wedge factor on the prescription point. A simple formula has been derived for the calculation of the effective wedge factor for the most general case, i.e. an arbitrary effective wedge angle, field size and prescription point. Relative dose calculations have been verified by measurements performed on a Varian Clinac 2300C/D linear accelerator, for 6 MV and 20 MV photon energies. Monitor unit calculations have also been verified experimentally for several cases such as symmetric and asymmetric fields with prescription on the collimator axis or on the geometrical centre of the asymmetric field. The presented technique provides results within 2% for both relative and absolute dose calculations for clinically relevant cases.

Algorithms↗

PubMedDate not supplied

[Use of a multileaf collimator for the production of intensity-modulated beams].

In external radiotherapy, the use of intensity modulated fields has been proposed for tissue and non-homogeneity compensation or for the generation of conformal dose distributions. Multileaf collimators can be employed dynamically for the modulation of the X-ray field in two dimensions. Efficient dynamic collimation became possible due to advances in computer and linear accelerator technology. It presents a number of advantages over conventional methods such as the use of compensators. We have developed a program which calculates, from a given intensity distribution, the motion of the MLC leaves as a function of monitor units, and we have applied it on a Varian linear accelerator with a 40 pair multileaf collimator. The analysis of the experimental results demonstrates the feasibility and the potential of the method.

Algorithms↗