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Biomedical subjects

S Parekh

Publications and source records attributed to S Parekh.

10 recordsLinked to original sources
PubMed1988

Pericardial cyst. A rare mass abutting the aorta.

Pericardial cysts are infrequently found. They are generally located in the cardiophrenic angle, dominantly on the right side. We present an example of a pericardial cyst in the anterior mediastinum abutting the ascending aorta.

Aged↗
PubMed1988

Magnetic resonance imaging of the orbits using a binocular surface coil.

Sixty subjects, including 12 normal volunteers, have been studied using the Aberdeen 0.08 T magnetic resonance imager. A wide range of pathological conditions, including both ocular and and orbital disease, have been examined using a specialized binocular surface coil. The images produced using this coil are superior to those made with a head coil and have the advantage of demonstrating both eyes simultaneously. Each patient has been studied using a pulse sequence combining alternate saturation-recovery and inversion-recovery pulses. The resultant short time-to-inversion inversion-recovery and saturation-recovery images have been shown to be accurate in demonstrating the normal anatomy of the globe and orbit and for the demonstration of a wide range of disease states.

Abscess↗
PubMed1984

Computer programs in nucleic acid synthesis: synthetic strategy development using solid-phase chemical techniques with data storage, retrieval and analysis capabilities.

A computer program has been designed to aid development of synthetic strategies for oligonucleotides produced by solid-phase chemical techniques. The program reduces the time required to develop a strategy and a data file from hours to minutes. The program contains inventories, provides cost analyses, and generates and stores other associated data. The program searches an inventory of sequences for that sequence to avoid duplicate synthesis. If the sequence is not in the inventory the program devises a synthetic strategy, calculates the amounts of reagents and labor costs necessary to complete the synthetic oligonucleotide. The program also deducts the reagents from inventory files. Physical data is also calculated. A file is generated in a sequence inventory for storage of the data as well as other data that will be generated during the purification processes. All variable parameters can be easily edited. The programs were designed to provide a cross-referencing feature for data analysis and can use several parameters as a constant.

Base Sequence↗
PubMed1984

Computer programs in nucleic acid synthesis: synthetic strategy development using solid-phase chemical techniques with data storage, retrieval and analysis capabilities.

A computer program has been designed to aid development of synthetic strategies for oligonucleotides produced by solid-phase chemical techniques. The program reduces the time required to develop a strategy and a data file from hours to minutes. The program contains inventories, provides cost analyses, and generates and stores other associated data. The program searches an inventory of sequences for that sequence to avoid duplicate synthesis. If the sequence is not in the inventory the program devises a synthetic strategy, calculates the amounts of reagents and labor costs necessary to complete the synthetic oligonucleotide. The program also deducts the reagents from inventory files. Physical data is also calculated. A file is generated in a sequence inventory for storage of the data as well as other data that will be generated during the purification processes. All variable parameters can be easily edited. The programs were designed to provide a cross-referencing feature for data analysis and can use several parameters as a constant.

Computers↗
PubMed1979

Synthesis and pharmacology of potential beta-blockers.

Several 1-(4-substituted phenoxyl)-2-hydroxy-3-isopropylaminopropanes and 1-(4-substituted phenoxy)-2-hydroxy-3-[3,4-dimethoxyphenethyl]aminopropanes were synthesized for possible beta-adrenergic receptor blockage. The compounds were synthesized by reaction of the 4-substituted phenol with epichlorohydrin and subsequent opening of the resulting epoxide with either N-isopropylamine or N-3,4-dimethoxyphenethylamine. Preliminary biological testing indicated a decrease in the beta-blocking potency and the duration of action.

Adrenergic beta-Antagonists↗