Biomedical subjects

S Patt

Publications and source records attributed to S Patt.

61 records · Page 4Linked to original sources

PubMed1989

[The question of medullomyoblastoma].

We report a 7 year old female presenting with a primary sarcoma of the frontal cortex, spinal cord metastases, and a cerebellar tumor. The latter was comprised of undifferentiated small cells and a component resembling rhabdomyosarcoma. On formal grounds it could be diagnosed either as medullomyoblastoma or rhabdomyosarcoma. At the ultrastructural level the tumor appeared more typical for a medullomyoblastoma but it seem highly improbable that both (rare) tumors appeared simultaneously by coincidence. Rather, we assume that we are dealing with a metastasis of the sarcoma with differentiation towards rhabdomyosarcoma. The apparent ability of a sarcoma to imitate morphological features of medullomyoblastoma in the cerebellum is further proof of the fact that nosological differentiation of both tumors remains a problem. Our findings did not corroborate the concept of medullomyoblastoma as a separate nosological entity.

Brain Neoplasms↗

PubMed1978

360 MHz PMR studies on the involvement of the Y-nucleoside in the conformation of 2'-OMeGpApApYpAppsi from torula yeast tRNAphe.

360 MHz measurements of chemical shifts, 3J1'-2', and T1 as a function of temperature for various protons of the hexanucleotide 2'-OMeGpApApYpAppsi from torula yeast tRNAphe have revealed a unique involvement of the Yt base in the structure and conformation of this oligonucleotide. Whereas the adenosine residues in the anticodon triplet are relatively stable to temperature increase, the Yt readily undergoes destacking and a change in ribose conformation. The destacking most likely involves a torsional displacement of the Yt base occasioned by a rotation of the phosphate-ribose backbone. The possible relevance of this unusual behavior to the influence of the Yt residue in tRNA function in protein biosynthesis is discussed.

Chemical Phenomena↗

PubMedDate not supplied

[The role of tumor infiltrating lymphocytes in the immunopathology of gliomas].

Immune response was studied to human glioblastoma with an accumulation of lymphocytes at the tumour site. The anti-tumour activity of the tumour infiltrating lymphocytes was confirmed by results from numerous investigations. The role of lymphocytes in gliomas is still widely discussed. Recent studies suggest a potential role of infiltrating lymphocytes as cellular effectors of angiogenesis. In this paper the authors discuss the immune response abnormalities especially with regard to the role of lymphocytes in angiogenesis.

Brain Neoplasms↗

PubMedDate not supplied

Intravascular papillary endothelial hyperplasia at the fissura orbitalis superior: a case report.

We report on a 27-year-old female suffering from headaches and nervus abducens paresis. Operation surprisingly revealed an intracranial intravascular papillary endothelial hyperplasia (IPEH) at the left fissura orbitalis superior visualized angiographically as a widening of the left ophthalmic artery. Clinical symptoms completely disappeared after the operation. IPEH is considered to be a rare benign lesion. Intracranial location has been reported only four times. The present case is the first IPEH described at the fissura orbitalis superior.

Adult↗

PubMedDate not supplied

In contrast to EGFr gene overexpression, H-ras gene expression decreases in human gliomas.

We have examined the expression of the epidermal growth factor receptor (EGFr) gene and 14 other oncogenes in several human gliomas. EGFr overexpression was apparent in 17 of 18 tumors. Nevertheless, remarkable amounts of aberrantly-sized EGFr mRNAs were not found in the 11 tumors examined. Among the 14 other oncogene probes employed, only the H-ras probe revealed changes in the expression level. The expression of this oncogene was 2-3-fold reduced in 13 of 18 tumors. In neural tissue the H-ras gene expression can be correlated with cellular differentiation. A correlation between H-ras protein expression and a favourable clinical prognosis was found in neuroblastomas. The decreased amounts of H-ras transcripts in gliomas may be a sign of a lower state of differentiation of the cells.

Brain↗

PubMedDate not supplied

Chromosomal changes and correspondingly altered proto-oncogene expression in human gliomas. Value of combined cytogenetic and molecular genetic analysis.

A combined cytogenetic and molecular genetic study was performed to analyze seven primary brain tumors: one oligoastrocytoma WHO-grade II, one anaplastic astrocytoma grade III, one anaplastic astrocytoma grade III/IV and four glioblastomas by G-banding and RNA dot blotting. A normal karyotype was found in the oligoastrocytoma. One of the two anaplastic astrocytomas (male) contained cells with a normal karyotype and cells with a Y-chromosomal loss, and the other one showed structural abnormalities too complex for complete analysis in mostly polyploid cells. Two of the four glioblastomas had few and the other two multiple chromosomal changes such as +7, +20, -8, -9 del(9)(p21), -10, del(10)(q24), -13,14, del(17)(p21), -22, add(3)(q13), double minutes and marker chromosomes. Compared to normal brain, all tumors had an increased EGFr and both anaplastic astrocytomas as well as three glioblastomas a decreased H-ras expression. The two glioblastomas with multiple chromosomal changes showed increased EGFr, Ki-ras, myb, mos and myc, decreased H-ras and N-ras and unchanged levels of abl, src and sis. Both the cytogenetic and molecular genetic findings are compatible even in the case of chromosomal losses, where the genes on the remaining allele may be responsible for dominant gene regulation mechanisms which result in a protooncogene overexpression. Our findings indicate that, apart from proto-oncogene overexpression, other mechanisms, e.g. tumor suppressor gene inactivation, are important for glial tumorigenesis. Karyotypic analysis makes it possible to search specifically for genetic events still unknown but arising from particular chromosomal changes.

Adult↗

PubMedDate not supplied

Metastasizing extraneural tumors along the CSF pathway.

Dissemination of metastases from primarily extraneural tumors with the cerebrospinal fluid (CSF) is rare and most often seen in association with a leptomeningeal involvement. Here we present 2 cases of bronchogenic and 1 case of prostata carcinoma with multiple CSF metastases within the entire cerebral ventricles and the spinal canal.

Aged↗