Biomedical subjects

S Pauli

Publications and source records attributed to S Pauli.

39 records · Page 3Linked to original sources

PubMed1988

Stereoselective binding of 11C-raclopride in living human brain--a search for extrastriatal central D2-dopamine receptors by PET.

The selective D2-dopamine receptor antagonist raclopride and its pharmacologically inactive (R)-enantiomer FLB472 were labelled with 11C and used in a study with positron emission tomography to examine the stereoselectivity of 11C-raclopride binding to central D2-dopamine receptors in three healthy men. After the injection of 11C-raclopride, there was a high accumulation of radioactivity in the dopamine-rich basal ganglia, whereas after the injection of 11C-FLB472 there was no such accumulation of radioactivity. Thus, the binding of 11C-raclopride is stereoselective. Distribution ratios [radioactivity in a brain region/"free" (not protein-bound) radioactivity in plasma] were calculated for the two enantiomers to study regional differences in the accumulation of radioactivity. The distribution ratios in white matter were similar for the two enantiomers. In the putamen, a three to four-fold higher distribution ratio was found for 11C-raclopride than for 11C-FLB472, reflecting the presence of specific binding of 11C-raclopride binding to D2-dopamine receptors in the basal ganglia. In the temporal and frontal cortices the distribution ratios were, however, only a few per cent higher for 11C-raclopride than for 11C-FLB472, indicating that if D2-dopamine receptors are present in the human neocortex, then their density is indeed very low.

Adult↗

PubMed1977

An acoustic-perceptual method for the quantitative evaluation of hypernasality.

A computer implementation is proposed as a method for assessing the quality of an individual's speech from a perceptual and communicative point of view. The input to this procedure is a standardized set of speech samples (vowels and selected consonants) designed to permit an evaluation of the speaker's phonology. The output is a numerical specification of the functional adequacy of the target values of the phonetic segments under analysis. The computer program consists of three parts: a simulated auditory analyzer, the output of which is a spectral representation of each test item; an algorithm that computes a psychoacoustically based measure of distinctiveness or perceptual distance for each pair of test spectra, and a routine for comparing, in terms of this measure, the test items with the corresponding reference items drawn from a population of normal speakers or a recording made before patient intervention.

Acoustics↗

PubMedDate not supplied

Acute colon diverticulitis in multiple myeloma patient: an unusual presentation of a colonic perforation. Case report.

This case report describes an acute colonic diverticular perforation occurred to a multiple myeloma patient, taking corticosteroid and morphine therapy, revealed by a subcutaneous emphysema of upper chest and right abdomen as initial presentation. Sigmoid diverticulitis with perforation and generalized peritonitis is a severe complication of the diverticular disease and it is due to diverticular microperforation. This condition occurs more frequently in patients with widespread diverticolosis and usually after 50 years of age, and the frequency of related complications increases with age (and with the use of corticosteroids). Extraperitoneal air from the sigmoid-rectum perforation can escape diffusing superiorly though paravertebral retroperitoneal tissues and via the diaphragmatic iatus into the mediastinum, producing pneumomediastinum and it diffuses to yield superior thoracic emphysema. This report suggests that the diagnosis of retroperitoneal perforation is usually difficult because of the lack of signs of peritoneal irritation and the paucity of symptoms, particularly in patients treated with corticosteroids.

Acute Disease↗