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Biomedical subjects

S Paydas

Publications and source records attributed to S Paydas.

At least 37 records · Page 2Linked to original sources
PubMed1999

Report on 59 patients with renal amyloidosis.

We studied a group of 59 patients with renal amyloidosis. Mean age (45 male, 14 female) was 33.05+/-13.04 years. All of the cases had secondary amyloidosis. The causes of secondary amyloidosis were as follows: familial Mediterranean fever (FMF) 18 (30.5%), pulmonary tuberculosis 12 (20.33%), chronic oseomyelitis 8 (13.55%), bronchiectasia 9 (15.25%), rheumatic diseases 4 (6.4%), Castleman's disease 1 (1.6%), unknown aetiology 7 (11.86%). Hypertension was detected in 15.3% of the cases. In patients with less than 20 ml/min creatinine clearance (Ccr) hypertension was found in 20%. Hypotension was detected in 6 patients and all of these cases had severe hypoalbuminaemia (<2.1 g/dl). Nephrotic range proteinuria (>3.5 g/day) was found in 75% of cases. Daily proteinuria was correlated with serum levels of albumin, total lipid and cholesterol, haematocrit and duration of disease. The mean Ccr was 51.03+/-40.60 ml/min. Twenty-nine per cent of patients had Ccr less than 20 ml/min. Renal, subcutaneous fat and rectal biopsies demonstrated amyloid in 100%, 20% and 57.6%, respectively, of patients tested. Patients with secondary amyloidosis were treated with colchicine in addition to the therapy of primary disease (in 6 patients). Nine patients died, and end-stage renal disease developed in 12 patients during four years of follow-up. Proteinuria disappeared or decreased in patients with secondary amyloidosis except secondary to collagen tissue disease, without advanced renal failure. Colchicine did not affect amyloid deposition in 2 patients with normal renal function and negative proteinuria, who were rebiopsied. It can be questioned that "Colchicine may have effect(s) for decrement on proteinuria". At least colchicine can be of use in secondary amyloidosis.

Adolescent↗
PubMed1999

Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders in Southern Turkey.

Anti-hepatitis C virus (HCV) antibody prevalence was investigated in 228 patients with lymphoproliferative disorders (LPDs). Twenty-six of 228 (11.40%) patients with LPDs were positive for anti-HCV which was higher than the donor population (P = 0.0007). Nine of 98 cases with non-Hodgkin's lymphoma, five of 47 cases with multiple myeloma, seven of 36 cases with Hodgkin's disease, four of 38 cases with chronic lymphocytic leukaemia and one of nine cases with acute lymphoblastic leukaemia had anti-HCV antibody. In all patients, odds ratio (OR) for anti-HCV was 24.09. This value was higher in patients less than 35 years as 62.04 for below 25 years and 32.00 for between 25-35 years. Our findings suggest that HCV infection might be a causative and/or contributing factor in lymphoproliferation.

Adolescent↗
PubMed1997

Bone marrow necrosis in antiphospholipid syndrome.

Bone marrow necrosis (BMN) is a relatively rare entity and has been associated with a poor prognosis. It is most commonly found in patients with neoplastic disorders, severe infections and sickle cell anemia. An unusual case of antiphospholipid syndrome (APS) with extensive bone marrow necrosis is described in a 27 year old woman. The patient presented with severe pancytopenia, some cognitive impairment resulting from a previous cerebrovascular accident, fever, hypertension, dyspnoea, tachycardia, hepatosplenomegaly, and vaginal bleeding. Her laboratory findings included a strongly positive Coombs' test (anti-IgG and anti-C3d), a prothrombin time of 23 seconds and an activated partial thromboplastin time of 45 seconds. Anticardiolipin antibody tests were positive. Antinuclear and anti-DNA antibodies were negative but the anti-SM test was positive. A bone marrow biopsy specimen was reported as showing extensive necrosis. The patient was treated with steroids, transfusion, and plasma exchange with some clinical improvement but her pancytopenia did not respond and necessitated frequent transfusions. This case lends further support to the association between APS and BMN.

Adult↗
PubMed1996

The frequencies of hepatitis B virus markers and hepatitis C virus antibody in patients with glomerulonephritis.

Hepatitis B virus markers and hepatitis C virus (HCV) antibody were assayed in 72 patients with glomerulonephritis (GN) at the time of biopsy. The patients, 41 males and 31 females, were aged between 16 and 68 years. The frequency of positivity for HbsAg, anti-Hbs, and anti-Hbe, anti-Hbc and anti-HCV antibody was 5.5, 20.8, 2.8, 16.6 and 1.4% respectively. At the same time, HbsAg and anti-HCV positivity were 8.5 and 0.95% in blood donors. We can say that morbidity and prognosis may be affected by hepatitis infection. Infections of hepatitis B and C have to be evaluated in patients with GN, especially in endemic areas. In our study group the frequencies of HbsAg positivity and anti-HCV positivity were not higher in patients with GN than in blood donors.

Adolescent↗
PubMed1996

Gastro-intestinal lymphoma in southern Turkey.

One hundred sixty three patients with primary gastro-intestinal lymphoma diagnosed during the last 10 years were reviewed retrospectively. Seventy five of them were female and 88 were male, aged between 14 to 80 years. Mean age for women was 36.8 +/- 17.6 years and 39.4 +/- 14.8 years for men. In 142 patients the disease was diagnosed by surgical intervention and endoscopic biopsy was used as diagnostic tool in only 21 patients. Tumour was located in the stomach in 61 cases in the mesenteric mass in 52 cases; in the small bowel in 42 cases; in the large bowel in seven cases and in the cases and esophagus in one case. Mean age for gastric lymphoma was 47.1 +/- 14.8; 42.2 +/- 14.3 for large bowel, 35.0 +/- 13.6 for mesenteric mass and 32.7 +/- 13.5 in small bowel lymphoma patients. Only four of the patients had stage I disease; 100 of them stage II disease and 59 had stage II-high tumour burden. Using the Working Formulation, 45 pc of the cases had low grade, 32 pc intermediate grade and 8 pc had high grade lymphoma, in 15 pc of the cases grading could not be achieved. In the low grade lymphoma stomach was the most common site and mesenteric mass in the intermediate grade lymphoma. One hundred and three cases were lost to follow up after surgery, so chemotherapy was given to 60 patients. Sixteen cases were lost to follow up in the early chemotherapy period and nine cases died while under chemotherapy. Three cases still receiving chemotherapy. Complete response was achieved in 32 cases. The stomach is the most common site for gastro intestinal lymphoma and occurs a decade earlier than other series in Southern Turkey. Low grade lymphoma accounts for 45 pc of the gastro-intestinal lymphoma. Chemotherapy is an important adjunctive therapy after an appropriate surgical intervention. Larger and further studies must be carried out on etiology, pathogenesis and management.

Adolescent↗