[Respiratory function in chronic renal insufficiency].
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Biomedical subjects
Publications and source records attributed to S Peneva.
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The analytical diffusion capacity of the lungs was determined in 63 patients with various stages of chronic renal insufficiency. On the base of the values of serum creatinine and glomerular filtration the patients were subdivided into four groups. Considerable changes in all the three values of alveolar-capillary diffusion (DLCO, Dm, Vc) were established, with a definite parallelism between those changes and the chronic renal insufficiency stage. The most serious changes concern the membrane component. The correlation analysis confirms the presence of high reverse correlation interdependence, both with the values of serum creatinine and blood urea and with the diastolic arterial pressure.
The results are reported from the carried out 701 shortterm therapeutic courses in 527 patients with exacerbated chronic pyelonephritis. The results are considered as "very good" in realization of a full clinical remission (normalization of temperature and ESR), disappearance of leucocyturia and bacteriuria), "good" - in normalization of three of those indices and "withfut effect". Co-trimoxazol (88.3 per cent of the patients), gentamycin (61.7%), ampicillin (58.8%), nelidix acid (57.4%), nitrfuran (55.0%) and choloramphenicol (53.1%) have manifested the highest effectiveness (very good and good effect). In a small number of the treated patients with cephalosporins effect was obtained in 50.0 per cent, with urovalidin - 44.4 per cent and with carbenicillin - 62.5 per cent. According to the authors' opinion the therapeutic schemes for a long-term treatment must include chlorampheniacal, nelidix acid, co-trimoxazol and nitrofuran sometives -amplicillin. Gentamycin, ampicillin and cephalosporins and with indications - some other uroantiseptics must be used in the coping with severe exacerbation of the disease. The authors recommend the chronic intermittent uroantiseptic treatment.