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Biomedical subjects

S Pennigerová

Publications and source records attributed to S Pennigerová.

9 recordsLinked to original sources
PubMed1990

Antibodies to human coronaviruses 229E and OC43 in the population of C.R.

Of 1200 human sera tested by enzyme-linked immunosorbent assay (ELISA), 53% contained antibodies to human coronavirus (HCV) 229E and 88% to HCV OC43. The sera were from persons aged 13 months to 80 years, both males and females, and were collected in four different regions in 1986. The percentage of positives increased with increasing age and tended to vary according to the geographic area. Additional paired human sera from 218 patients with acute respiratory diseases (ARD) were collected between October 1986 and June 1987 in Prague. Significant antibody rises to HCV strain 229E were detected in 7 (3.2%) patients 9 months to 17 years old, to HCV strain OC43 in 4 (1.8%) patients under 2 years of age.

Adolescent↗
PubMed1990

[Clinical diagnosis and laboratory study of acute respiratory diseases of viral origin in children].

The authors analyzed retrospectively a group of 477 children aged two months to 16 years (mean age 6 years and 5 months), hospitalized on account of acute respiratory disease and subjected to virological examination. The aetiology was revealed in 53% of the sick children. In the elucidation of the aetiology participated a number of respiratory viruses, in particular the respiratory syncytial virus. The clinical picture of the disease was very varied. It was confirmed that the clinical picture does not make it possible to express in a considerable proportion of patients suspicion of an actual infectious aetiology. A mixed aetiology of acute respiratory diseases and a varied clinical picture indicate the necessity of a rapid virological and bacteriological examination in hospital practice.

Acute Disease↗
PubMed1989

[Acute respiratory disease caused by coronaviruses].

Serological evidence of coronavirus aetiology was found in 11 patients out of 218 persons examined (5%) in the period of 1986-1987, and in 23 cases out of 311 patients (7.4%) in the period of 1987-1988. Antibody titres with a minimum of four-time elevated values in paired sera using the ELISA method were considered conclusive. Coronaviruses 229E and OC43 were employed. During the first period, more persons were infected by coronavirus 229E, while in the second period, by coronavirus OC43. The disease was equally spread over all the months of the years. For example, in the 1987-1988 period, most infections occurred in February, when out of 60 examined patients, 9 were coronavirus positive (15%).

Acute Disease↗
PubMed1989

[A case of Pelger-Huet anomaly in a premature infant].

The report deals with a prematurely born child affected with multilateral anomalies of body development, defect of cell immunity and acquired Pelger-Huët's anomaly. Pelger-Huët's anomaly was detected in a blood smear during the third week of life by an extreme deviation to the left, the degree of which fluctuated, however, depending on the reiterating exacerbations of the infect. The morphological changes of blood elements persisted until exitus letalis in a severe respiratory infect. The changes of the karyotype and possible relations to Pelger-Huët's anomaly and malformations of development are discussed in detail.

Abnormalities, Multiple↗
PubMed1981

Antibody to parainfluenza virus types 1, 2 and 3 in sera and nasal secretions of persons of different age.

Serum and secretory antibody levels against 3 types of parainfluenza virus were determined in persons ranging in age from 1 month to 74 years. With a slight decline in the group of 7 months to 2 years of children, the number of positive findings increased with age, reaching maximum in the groups of 16-24 years [types 1 and 2] and 25-74 years [type 3] old persons. Nasal secretory antibodies against parainfluenza type 3 virus were detected in all age categories, the highest number of positive findings occurred in the group of 16-24 years old persons. Secretory antibodies against type 2 virus were detected also in all age groups, but the number of positive findings was considerably lower. Secretory antibodies against type 1 virus were detectable in persons over 5 years of age, with a maximum in the age category of 16-24 years. The percentage of positive persons with antibody to type 1 virus was the lowest.

Adolescent↗