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Biomedical subjects

S Petta

Publications and source records attributed to S Petta.

14 recordsLinked to original sources
PubMed2006

Transrectal colour Doppler contrast sonography in the diagnosis of local recurrence after radical prostatectomy--comparison with MRI.

OBJECTIVE: To assess the usefulness of colour power-Doppler transrectal sonography before/after contrast agent in the detection of local recurrence in patients with rising prostate-specific antigen values after radical prostatectomy and to compare with magnetic resonance imaging . MATERIALS AND METHODS: 18 patients with rising prostate-specific antigen values after prostatectomy underwent digital rectal examination, bone scintigraphy, magnetic resonance imaging, transrectal colour power-Doppler sonography before/after contrast agent, and transrectal sonography-guided biopsy. Sensitivity, specificity, accuracy, positive and negative predictive values were calculated. Results were correlated using McNemar binomial 2-tailed P-test. RESULTS: Baseline and contrast-enhanced transrectal colour power-Doppler sonography and contrast-enhanced magnetic resonance imaging identified recurrent disease in 6, 10 and 10 patients, respectively. Biopsy confirmed recurrence in 10 patients, but was positive also in 2 additional patients who were negative at contrast-enhanced transrectal colour power-Doppler sonography and contrast-enhanced magnetic resonance imaging. The remaining 6 patients were negative also at diagnostic imaging and biopsy after 30 days. Grey-scale transrectal sonography values were: sensitivity 91.7 %, specificity 66 %, PPV 91.6 %, NPV 40 %. Baseline colour power-Doppler transrectal sonography values were: sensitivity 38.5 %, specificity 85 %, diagnostic accuracy 50 %, PPV 83.3 %, NPV 33.3 %. Contrast enhanced colour power-Doppler transrectal sonography and magnetic resonance imaging values were: sensitivity 76.9 %, specificity 100 %, diagnostic accuracy 83.3 %, PPV 100 %, NPV 62.5 %. CONCLUSION: Contrast-enhanced transrectal colour power-Doppler sonography increases specificity in the detection of local recurrence after prostatectomy. Magnetic resonance imaging yields equivalent accuracy. Biopsy remains the diagnostic gold standard, but the use of imaging methods may reduce the number of biopsies.

Aged↗
PubMed2000

[Rational approach to the patient with urination disorders caused by cervico-urethral obstruction].

Benign prostatic hypertrophy is the most frequent cause of cervico-urethral obstruction in adults. The symptomatology is complex and varied, and includes both irritative and obstructive symptoms. A number of methods are used to evaluate-quantify obstruction caused by benign prostatic hypertrophy. A series of tests are traditionally used to identify disorders caused by altered vesical filling (LUTS) and the degree of obstruction (BOO). An analysis of the various methods generally allows the most suitable treatment to be commenced. This critical review aimed to identify the real value and specificity of each method in relation to the possibility of quantifying the degree of cervico-urethral obstruction.

Humans↗
PubMed1998

[Urothelial neoplasia as a late complication of transitional-cell carcinoma of the bladder].

We evaluated the long term incidence of lower urinary tract neoplasms in patients with primary transitional bladder carcinoma. 8 patients had lower urinary tract neoplasm after a median elapse of time of 44 months (range 28 to 70). In 5 patients wa present vesicoureteral reflux. All the patients were undergone trial of BCG after the first recurrence of bladder carcinoma. We suppose that the vesicoureteral reflux may be the possible cause of ureteral neoplasm onset. Because of patients with primary bladder tumors are at the risk for lower urinary tract neoplasm, we suggest the need regular and continuous monitoring in case of frequent recurrence of transitional cell carcinoma of the bladder.

Adult↗
PubMed1997

[Radiologic staging after surgical, chemical, and radiation treatment of non-seminomatous tumors of the testis].

The aim of this work was to evaluate the clinic usefulness of Computed Tomography (CT) and Magnetic Resonance (RM) in the staging after surgery, radiotherapy and chemotherapy of the nonseminomatous germ cells tumours of the testis. The Authors discussed the CT and MR dimensional criteria for the diagnosis of retroperitoneal metastases of the nonseminomatous germ cells tumours and delineated their CT and MR morphologic appearances in detail. The density of the residual mass on CT was classified as solid, cystic and half-cystic. The retroperitoneal hematoma and lymphocele formed as a complication respectively of orchiectomy and retroperitoneal lymphadenectomy can be misinterpreted to represent metastatic disease on post operative staging CT scans. Early recognition of this complication are crucial if unnecessary treatment is to be avoided. Finally the Authors evaluated, in patients affected from nonseminomatous germ cells tumours of the testis, the possibility to characterize with CT and MR imaging the retroperitoneal mass. The density and character of the residual mass on CT scan did not reliably predict the histology. On the basis of tumor consistency and signal intensity in T1 and T2 weighted images, MR cannot yet warrant any conclusion about the ultimate effect of chemotherapy.

Germinoma↗
PubMed1989

[Aztreonam and aminoglycosides in the therapy of urinary infections associated with renal calculosis].

Renal calculosis associated with urinary tract infections due to urease-positive or -negative microorganisms poses difficult therapeutic problems. The introduction of monobactam antibiotics such as aztreonam offers a valid therapeutic alternative thanks to the action of this drug on the gram-negative organism often at the root of these infections. The above study has been carried out in 10 patients with infections due to organisms sensitive to aztreonam and aminoglucosides. Treatment with aztreonam (1 g i.m. 3 times daily) brought about sterilization lasting from 3 weeks to permanently in 5 cases. In one case sterilization was transitory and in 4 cases treatment was unsuccessful. Creatinine blood level and other biochemical parameters did not vary. Aminoglucosides alone brought about transitory sterility in 2 cases and was unsuccessful in 6. At the end of treatment, creatinine blood level had increased significantly. Given the absence of toxicity the definitely better therapeutic result, and the absence of induced resistance, aztreonam should be considered the drug of choice and should be preferred to aminoglucosides for the management of urinary tract infections due to microorganisms sensitive to both types of drugs in patients with urinary calculosis.

Adolescent↗
PubMed1979

Results of medical treatment of cystine lithiasis.

Litholytic and prophylactic medical treatment of cystine lithiasis in 42 patients over a 5-year period is reported. Treatment consists of administration of urinary alkalizing agents and alpha-mercaptopropionylglycine. Successful results were obtained in a high percentage of cases.

Adult↗