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S Poser

Publications and source records attributed to S Poser.

At least 19 recordsLinked to original sources
PubMed1979

Clinical data and the identification of special forms of multiple sclerosis in 1271 cases studied with a standardized documentation system.

In a multicenter study the clinical data of 1271 patients with multiple sclerosis (MS) were recorded in a standardized manner and analysed by a computer program. Some of the retrospective data are compared with previous reports. The frequency of optic nerve involvement in the present series was close to the Japanese figures. The development of signs and symptoms during the course of MS was given for the 1271 patients and differences in the reversibility of symptoms are presented. In this study, one of the chief purposes was the selection of groups of MS patients with particular symptomatology and course of the disease for prospective, detailed study. The following groups were selected and are under further investigation: 109 patients with an exclusively spinal symptomatology throughout the course of their disease; 441 patients with optic neuritis as initial symptom; 110 patients with early brain-stem involvement; 64 benign cases (duration of the disease more than 14 years and disability not more than 3 according to Kurtzke), 35 malignant cases (duration of the disease under 5 years and disability grade of 7 or more); 83 families with more than one member with MS; 289 females with a history of pregnancy, childbirth and/or use of oral contraceptives. In 339 patients a lumbar puncture was performed at the present examination. The parameters determined constitute a pathognomonic pattern highly indicative of the diagnosis of MS.

Brain Stem↗
PubMed1978

Clinical features of the spinal form of multiple sclerosis.

Out of a data pool of 1271 patients with Multiple Sclerosis (MS) a total of 109 cases are selected having a sole spinal symptomatology throughout the course of the disease. This group differs in three particular features from the non-spinal forms of MS: In this group there is a higher percentage of females, the age at onset of the disease is higher, and the course of the disease is more often chronic progressive from the beginning. After the mean duration of 11 years, the spinal and the non-spinal cases show the same grade of disability. The ability to work is slightly better for spinal cases; office workers are able to keep their jobs longer after the onset to the disease than patients with any other occupation. The spinal form of MS is discussed in respect to its relationship to the classical form of MS and as a differential diagnosis to other spinal processes.

Adult↗
PubMed1978

[The social and medical situation of people suffering from multiple sclerosis--considerations on the basis of an epidemiologic field study (author's transl)].

Within the framework of an epidemiologic field study conducted in South Niedersachsen a standardised questionnaire was used to obtain data on the social and medical situation of persons with multiple sclerosis. Of the 195 people with multiple sclerosis questioned in that area in 1976 answers were received from 178 (91%). The mean age was 46 years, the average history of disease 15 years. Family status and social position corresponded to social average. A social downfall as a result of the disease was not found to have taken place. Approximately 50% who had been employed prior to the disease (N = 147) had given up their jobs at the time of the survey. The monthly net income was found to be average. Of the studied persons 42% were living in their own houses or flats. A lower percentage, compared to the general public, was living in lodgings (58% instead of 65,7%). The majority (56%) was living in flats suitable for the disabled. 13% of the surveyed persons lived alone, 5% in homes. Social care was found to be very poor in comparison with medical treatment. The introduction of compulsory notification for this disease was advocated by 83% of the people questioned.

Adolescent↗
PubMed1977

Serological response of multiple sclerosis patients and controls to 6/94-parainfluenza virus.

The serological responses of 195 multiple sclerosis (MS) patients and 251 controls were tested against 6/94-parainfluenza virus, which was previously isolated from brain tissue of two patients with MS. The hemagglutination-inhibition titers of greater than or equal to 1: 128 were found more frequently in MS patients (21.5%) than in controls (14.0%). However, the geometric mean titers did not differ between these two groups. The present study concludes that a causal relationship of 6/94-virus to MS, based on a specific immune response, is improbable, although it does not exclude the possibility of a pathogenetic significance of the agent in the cases from which the autopsy material was derived.

Adult↗
PubMed1977

Protein profile of cerebrospinal fluid in multiple sclerosis with special reference to the function of the blood brain barrier.

The leucocyte count, total protein, albumin, IgG, IgA and IgM content of the cerebrospinal fluid (CSF) of 103 multiple sclerosis (MS) patients was determined. In 54 cases a simultaneous analysis of serum was also carried out. As a sign of an intact blood brain barrier the albumin concentration was normal in 76.7%. Taking into account the relative IgG quotient in CSF and serum, and the albumin and IgG concentration gradients between CSF and serum, it was possible to reveal an elevation of IgG content in CSF of MS patients in 75 and 83%, respectively. Without a simultaneous analysis of serum this was the case only in 51.5%. In MS cases with an intact blood brain barrier the values for IgA and/or IgM were slightly elevated in 11.7%. This study demonstrates analytic methods, which support the hypothesis of IgG synthesis by cells accumulating within the CNS in MS. A correlation of the laboratory results and clinical manifestation of MS was tried.

Adult↗
PubMed1977

[Oral contraceptives--indications and neurological complications (author's transl)].

The influence of oral contraceptive agents on neurologic diseases in not clear. Animal experiments suggest that estrogens lower the seizure threshold whereas gestagens have the opposite effect. In women with epilepsy no change in the pattern of attacks could be observed under oral contraceptives. The inducing effect of hydantions and barbiturates on drug metabolizing enzymes requires the prescription of higher doses of estrogens and gestagens. Otherwise unwanted pregnancy can result, an especially unfavourable event in regard to the teratogenicity of hydantoins and barbiturates and possibly or oral contraceptives, too. An immunosuppressive effect of oral contraceptives - found in animals with EAE--could be favourable in respect to the disturbed immune mechanism of patients with multiple sclerosis and myasthenia. The influence of oral contraceptives on migraine seems to vary. The risk of arterial cerebral thromboembolic disease is increased in women taking oral contraceptives. The correlation to the estrogen content of the drugs remains to be proved.

Barbiturates↗
PubMed1975

[Indications for stereotaxic neurosurgery of patients with multiple sclerosis (author's transl)].

The long-term results of 12 stereotaxic operations on 11 multiple sclerosis patients with incapacitating intention tremor were evaluated and compared with the experiences of other authors. The selection of the patients, the criteria applied for the success and the length of the follow-up period influenced the reported results. Considering not only the relief of the intention tremor but the overall performance after the operation only a certain group of patients seemed to profit by neurosurgical treatment. Applying this criterion of overall performance and evaluation only 3 out of 11 patients in our series had real benefit from the operation. The reasons for this small number of good or moderate results are given with brief discussion of some of the cases. History, course and fatal outcome of one patient are presented in detail together with the neuropathological findings. According to the literature and the limited number of our own cases the following indications for stereotaxic operations on MS patients can be established: 1. Tremor and hyperkinetic movements should be the dominant features of the symptomatology. 2. The overall performance should be essentially improved by the operation. 3. Patients in the terminal stage of the disease gain little from the procedure, whereas patients with longstanding more benign course are the best candidates.

Adult↗