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S Poticha

Publications and source records attributed to S Poticha.

6 recordsLinked to original sources
PubMed1997

Cholecystokinin modulates mucosal immunoglobulin A function.

BACKGROUND: We have established that mucosal immunoglobulin A (IgA) production is highly dependent on cholecystokinin release and is markedly suppressed by glucocorticoids. The purpose of the present study was to examine the role of cholecystokinin on the functional responsiveness of the mucosal IgA system in glucocorticoid treated rats. METHODS: A total of 24 Fischer rats were assigned to three groups of 8 animals each. Animals were injected with vehicle (CON), dexamethasone (DEX) (0.08 mg/150 g), or DEX (0.08 mg/150 gm) and ARL1294KF (500 ng twice daily), a novel and potent long-acting cholecystokinin agonist (DEX+CCK). Animals were treated for 48 hours and killed. Duodenum was harvested, and the total mucosal concentration of cholecystokinin was measured by radioimmunoassay. Mucosal IgA was assayed by quantitation of immunoreactive cells in the ileum. Bacterial adherence was evaluated by quantitative culture of vigorously washed stripped cecal mucosa. Transepithelial electrical resistance, a measure of tight junction permeability, was assessed by mounting strips of adjacent cecal mucosa in Ussing chambers. RESULTS: Glucocorticoid administration resulted in a statistically significant (p < 0.001) decrease in duodenal cholecystokinin, decreased IgA, and impaired mucosal immunity (increased bacterial adherence and decreased tissue resistance). Cholecystokinin administration preserved mucosal immune function in DEX-treated rats. CONCLUSIONS: Cholecystokinin may play an important role in maintaining the functional responsiveness of mucosal immunity during catabolic stress.

Animals↗
PubMed1987

Mortality and morbidity of gastric 'pull-up' for replacement of the pharyngoesophagus.

Forty-two patients have undergone gastric interposition to replace the pharyngoesophagus; 39 patients had primary or recurrent malignant tumors of the hypopharynx, cervical esophagus, postcrioid area, or tracheal stoma, while three patients had benign disease. The operation consisted of resection of the local neck disease, along with a transhiatal esophagectomy and gastric "pull-up" for restoration of gastrointestinal tract continuity. Eight hospitalized patients died, for a mortality rate of 19%, of which six patients died of complications from local sepsis. The more common nonfatal complications were related to the neck wound, the anastomosis, and the stomach. The complication rate per patient, excluding postoperative deaths, was 40%. The average length of stay was 44 days for the patients with nonfatal complications and 23 days for those without complications. The success rate of the operation with relief of the patients' presenting symptoms was 81%.

Adult↗
PubMed1978

Granulomatous hepatitis and pleuritis after ileal bypass for obesity.

A patient is presented who developed a granulomatous hepatitis and pleuritis approximately 7 months after an ileal bypass procedure for morbid obesity. Although the etiological agent was presumed to be Mycobacterium tuberculosis no pathogenic organism was grown from the liver, pleura, bone marrow, sputum, or gastric aspirate. The possibly increased susceptibility of these patients to mycobacterial infections is discussed. The value of obtaining serum levels of ethambutol, isoniazid, and rifampin, in patients with malabsorption is stressed. Although this patient seemed to respond to antituberculous therapy, other possible causes for the granulomatous process are explored.

Ethambutol↗