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Biomedical subjects

S Potkay

Publications and source records attributed to S Potkay.

15 recordsLinked to original sources

Diseases of the Callitrichidae: a review.

The Callitrichidae contains four genera that embrace up to 50 species and subspecies found in neotropical habitats. Certain members have either naturally occurring or induced conditions that serve as important models of human disease. They include viral, bacterial, and parasitic infections, nutritional deficiencies, neoplasia, and various other conditions. The spontaneous diseases of captive callitrichids and those to which these species are experimentally susceptible were reviewed.

Animals

Mycobacterium scrofulaceum infection in Erythrocebus patas monkeys.

Mycobacterium scrofulaceum was cultured from two of seven tuberculin reactors in a group of 12 Erythrocebus patas monkeys. One monkey reacted atypically to 0.1 ml of 2.5 mg veterinary tuberculin after having shown no reaction to four previous tests administered at 2-week intervals. The reaction consisted of edema with no induration or erythema at 24 hours and was completely dissipated at 36 hours. Responses to additional tests using veterinary tuberculin (2.5 mg) and Mycobacterium bovis purified protein derivative (1.1 mg) ranged from negative to slightly edematous. Radiographs were suggestive of pulmonary tuberculosis. Extensive granulomas were observed in the lungs, liver and spleen at necropsy. Mycobacterium scrofulaceum was isolated from lung and liver granulomas in this animal and from lung granulomas in another. The atypical skin hypersensitivity and organism isolation from multiple organs suggested Mycobacterium scrofulaceum as the etiologic agent in these animals. Reactions of six other Erythrocebus patas to veterinary tuberculin (2.5 mg) ranged from edematous to indurated.

Animals

Morbidity and mortality in a closed foxhound breeding colony.

A 3-year mortality and morbidity survey was conducted in a research foxhound breeding colony. Its purpose was to identify specific problem areas for further study and rectification. Three-hundred and thirty-nine litters (2,872 puppies) were whelped. Seventeen percent (17.4%) of the puppies died before weaning and 4.0% died between weaning and 30 weeks of age. Major puppy losses (55.6% of the total mortality) occurred during the 1st week after birth. The majority of deaths during this period was attributable to stillbirth, immaturity or runting, trauma and congenital abnormalities. The predominant causes of death thereafter were pneumonia, malnutrition, and gastrointestinal disease. The most frequent causes of morbidity among puppies were respiratory disease, anorexia and dehydration, skin disorders, and gastrointestinal disease. These entities were most commonly observed during the 2 weeks before and after weaning at 6 weeks of age. Clinical disease problems among breeding stock were few and were easily resolved. Fighting and infections of the skin and ear canals constituted 75.5% of the cases observed.

Animals

An evaluation of sedatives and anesthetics in the agouti (Dasyprocta sp).

Seven drugs administered im were evaluated to determine their efficacy in immobilizing captive agoutis. Ketamine HCl (63-83 mg/kg) and phencyclidine HCl (16.5-22.0 mg/kg) produced immobilization and analgesia. Phencyclidine administration was accompanied by numerous side effects and prolonged recovery. Xylazine HCl (3-70 mg/kg) and fentanyl-droperidol (0.28-1.11 ml/kg( produced varying degrees of ataxia and intermittent recumbency. Acetylpromazine, chlorpromazine, and promazine HCl were ineffective. Surgical anesthesia was successfully induced and maintained with halothane.

Analgesia

The agouti (Dasyprocta sp) in biomedical research and captivity.

Agoutis (Dasyprocta sp) are hystricomorph rodents belonging to the family Dasyproctidae. Utilization of agoutis in a research program of the National Institutes of Health necessitated the development of suitable methods for feeding, housing and collecting blood. The rodents were maintained successfully in conventional dog cages and kennels, and thrived on a diet of primate diet and apples. Physical examinations and periodic blood collections were best performed while agoutis were sedated with ketamine HCl (42-83 mg/kg, intramuscularly). Satisfactory sites for blood sampling were the cephalic, saphenous and jugular veins. Hematologic and serum chemical values established for the agouti were similar to those found in other rodents. Experimentally induced and naturally occurring diseases of agoutis were reviewed.

Anesthesia

Compression plating of radial and ulnar fractures in the goat.

Internal fixation of radial and ulnar fractures in three goats was accomplished using bone plates. Intervals between the time of fracture and internal fixation varied from one to 13 days. The goats were ambulatory the day after surgery, and recoveries were uneventful.

Anesthesia, Inhalation