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Biomedical subjects

S Prasad

Publications and source records attributed to S Prasad.

At least 109 records · Page 6Linked to original sources
PubMed1999

Association study of schizophrenia among Indian families.

A putative association of schizophrenia with a Msc I restriction fragment length polymorphism at the dopamine D3 receptor gene locus (DRD3) was tested among Indian families, using haplotype relative risk analysis and the transmission disequilibrium test (n=66 families and 58 sets of transmissions, respectively). A significant association either with homozygosity or with allele 1 at the biallelic polymporphism could not be detected.

Female↗
PubMed1999

Pure-phase two-dimensional niobium-93 nutation spectroscopic study of lead metaniobate and the piezoelectric lead magnesium niobate.

An NMR technique to measure pure-phase two-dimensional nutation NMR spectra, that yields higher resolution than traditional nutation experiments is reported. Using this technique 93Nb nutation NMR spectra of PbNb2O6 and the technologically important Pb(Mg1/3Nb2/3)O3 (PMN) have been measured and the quadrupolar coupling constant of the niobium site in PbNb2O6 (C(Q) = 19 +/- 2 MHz) determined. Estimates of the quadrupolar coupling constants for three different resonances associated with different niobium(V) sites in PMN (C(Q) < 1.2 MHz, approximately 17 MHz, and > 62 MHz) are also reported.

Lead↗
PubMed1999

Partial anodontia in a case of Waardenburg's syndrome.

On routine examination of a case of Waardenburg's syndrome apart from the usual features of the disorder, partial anodontia involving both the lower lateral incisors was evident. The interesting association of partial anodontia and Waardenburg's syndrome is discussed along with relevant available literature.

Adolescent↗
PubMed1999

Digital fundus imaging: a quality and cost comparison with 35-mm film.

PURPOSE: This study compares 35-mm transparencies with colour digital fundus images. METHODS: Colour fundus photos were acquired simultaneously on a digital system and on 35-mm film on 32 consecutive patients. These were assessed independently by two ophthalmologists who graded overall picture quality and granularity of the images. They also assessed if the images were adequate for the purpose of making a diagnosis. An analysis of the costs of the two systems was performed. RESULTS: The film images had significantly better scores for overall picture quality (p=0.0001, 95% CI 0.5 to 1.5) and granularity (p<0.0001, 95% CI 1.5 to 2). However, both digital and film images were considered adequate for diagnosis (p=0.052, 95% CI 0.12 to 8.32). CONCLUSION: The quality of digital images is acceptable for diagnostic purposes although resolution is limited. Other advantages and developing technologies will make it increasingly attractive in the future.

Cost-Benefit Analysis↗
PubMed1999

Methanol poisoning: brain computed tomography scan findings in four patients.

Methanol, through its chief metabolite, formate, causes irreversible neurological damage. Methanol intoxication produces classic neuropathological changes and characteristic imaging findings. Computed tomography was performed on four patients who presented with a history of methanol poisoning. Prominent, hypodense lesions in the lentiform nuclei and peripheral white matter, sometimes with haemorrhage, were the characteristic imaging findings in the present patients. It was noted that the severity and extent of necrosis of the lentiform nuclei do not necessarily correlate with the clinical outcome.

Adult↗
PubMed1999

Fluid-fluid levels in intracranial schwannomas.

Intracranial cystic neurogenic tumours constitute an uncommon subset of tumours with a distinct clinico-biological behaviour. The presence of fluid-fluid levels within the tumours, although rare, confirms the cystic nature of the neoplasms. Barring the acoustic schwannomas, cystic cranial nerve schwannomas are exceptionally uncommon. Imaging findings of fluid-fluid levels in two non-acoustic cranial nerve schwannomas are described; one was a cystic trigeminal schwannoma and the other was a glossopharyngeal nerve schwannoma. The causes of the fluid-fluid level and its implications are analysed.

Adult↗
PubMed1999

Computed tomography demonstration of a fat-fluid level in tuberculous chylous ascites.

The occurrence of fat-fluid levels in ascites, although rare, is pathognomic of chylous ascites. The ultrasound and CT scan findings of a fat-fluid level in the ascitic fluid of a patient with abdominal tuberculosis are described here. Recognition of this important sign, in conjunction with other ancillary findings of abdominal tuberculosis, assist in establishing the correct diagnosis. Anti-tuberculous chemotherapy suffices in treating the condition, thus obviating the need for surgical intervention.

Adult↗
PubMed1999

Medicolegal response to violence against women in India.

This article examines women's experiences in India with health and legal interventions that address domestic violence, dowry-related violence, and rape. By examining the experiences of survivors of abuse with the medicolegal system in New Delhi, it considers the extent to which women are able to access their legal rights within the special protection system constructed specifically for them. The use of primary data highlights the impact of state procedures on women, and it demonstrates how procedures designed to enhance women's access to the law actually inhibit it. Using semistructured interviews with female survivors of abuse, police officers, case workers, nongovernmental organization leaders, lawyers, physicians, and government officials in a 4-year period, this article examines women's access to state services designed to address violence against women, and raises questions about state tolerance of domestic and sexual violence.

Asia↗
PubMed1999

Metanephric adenoma in a solitary kidney.

A case of metanephric adenoma occurring in a solitary kidney of a 31-year-old man is presented. Metanephric adenoma is extremely rare and its diagnosis should be considered in a patient with a well circumscribed renal tumour and concomitant paraneoplastic syndromes. Radiological features of the tumour are non-specific and histopathological examination is essential to establish a definitive diagnosis. Recognition of the tumour is of potential importance as conservative treatment with complete surgical enucleation will suffice in all cases.

Adenoma↗
PubMed1999

Intermediate filament proteins during carcinogenesis and apoptosis (Review).

The intermediate filament network spreading from the cell periphery to the nucleus forms dynamic linkages between nuclear matrix, actin microfilaments, and the extracellular matrix. The six different types (types I-VI) of IF proteins consisting of nearly 50 different proteins form at least nine different kinds of filaments depending on the tissue types: keratins, lamins, vimentin, desmin, neurofilaments, peripherin, alpha-internexin, glial fibrillary acidic protein and nestin. Their tissue specific expression in normal cells and differential expression/assembly in neoplasia has been of immense value in tumor diagnosis. At the same time, recent in vitro studies point out that keratins, lamins and vimentin are subject to caspase-mediated proteolysis in an apoptosis-related manner. We reviewed the experimentally demonstrated P4-P1 motif specificities of caspases in the selection of substrates in the IF protein family. In addition, we provided clues to possible cleavage of additional IF proteins during programmed cell death, based on acceptable cut site motifs indicated by searches using the PIR protein sequence database. The present review concludes with presentation of evidence on the emerging roles of IFs in association with intermediate filament associated proteins in the dynamic remodeling of the cell during development of neoplastic phenotype and execution of apoptosis.

Amino Acid Sequence↗
PubMed1999

Hyperthyroidism due to papillary carcinoma of the thyroid--a case report.

A rare case of papillary carcinoma of the thyroid producing hyperthyroidism is presented. A young patients presented seven years after a thyroid operation with metastatic disease in the cervical lymph nodes and a history of deteriorating vision in the left eye. He also had a lesion in the base of the skull which could not be established to be metastasis from the thyroid cancer. There was clinical and biochemical evidence of hyperthyroidism. Radionuclide scan revealed uptake in the residual thyroid tissue and patchy uptake by the cervical lymph nodes. The patient underwent a complete thyroidectomy and radical neck dissection of the left side and 'berry-picking' of the lymph nodes on the right side. Although the patient became euthyroid post-operatively, his general condition deteriorated and he rapidly lost vision in both eyes before any ablative therapy could be instituted for the tumour in the base of the skull. The patient was lost to follow-up.

Adult↗