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Biomedical subjects

S Pridmore

Publications and source records attributed to S Pridmore.

At least 37 records · Page 2Linked to original sources
PubMed1998

Motor threshold in transcranial magnetic stimulation: a comparison of a neurophysiological method and a visualization of movement method.

Motor threshold is a means of quantifying stimulus in transcranial magnetic stimulation. Two methods are used. One involves neurophysiology techniques and the other is visualization of movement. The aim was to compare the percentage of total machine output (PTMO) necessary to achieve motor threshold using these different methods. Neurophysiological and visualization of movement thresholds were determined in six subjects. In all subjects, the two thresholds were achieved with a < 10% difference in PTMO. Determination of motor threshold with a neurophysiological and a visualization of movement method produced similar results.

Adult↗
PubMed1997

Bridging the skull: electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS) in psychiatry.

A brief account of repetitive transcranial magnetic stimulation (rTMS) with reference to electroconvulsive therapy (ECT) is given, identifying similarities and dissimilarities, and discussing their potential therapeutic roles. The insulating properties of the skull prevent specific, noninvasive stimulation of particular brain regions by direct electrical means. ECT allows electrical stimulation of the cortex, but its concomitant seizures and distributed electrical currents can have adverse effects on patients. By contrast, magnetic fields pass almost without attenuation through the skull, and can induce secondary electrical currents in localized areas of the brain. Subconvulsive rTMS does not require seizure or general anesthetic, and does not affect memory. Recent studies suggest that rTMS has therapeutic potential for mood disorders, for which ECT is well established. rTMS is a new technology with the potential to treat some mental disorders currently treated with ECT, with fewer side effects. ECT will almost certainly remain the treatment of choice in some situations, but ECT and rTMS may be alternatives for other patients. It is possible that rTMS will become established in some areas where ECT is not used. Further research will define these roles and evaluate the utility of rTMS.

Brain↗
PubMed1996

Hanging and poisoning autopsies in Fiji.

OBJECTIVE: Fiji is a Pacific nation with roughly equal numbers of indigenous Fijians and Indians. Previous studies, using police and medical records, have suggested significant racial, regional, age and gender differences in suicidal behaviour. The objective of the present study is to use a unique data set (autopsy reports) in the evaluation of earlier reports and to identify groups at greater risk. METHOD: Hanging and poisoning autopsy reports from two distinct regions were examined. RESULTS: The rate of autopsy (per 100000 population per year) among Indians (19.5) is significantly greater (p < 0.0001) than among Fijians (1.53). In the north, among the Indians, there are more autopsies in females (21.2) than males (16.8), and hanging constitutes 85% of total suicides, while in the Central and Eastern Divisions hanging constitutes only 58% of the total. These are regional influences. Among Fijians, the rates of hanging autopsy are significantly greater (p < 0.001) in males (1.98) than females (0.40); however, among Indians there is no significant difference. This is a racial difference. Hanging remains the preferred option for all groups. The mean age at autopsy is 31.7. There is no significant difference between the mean ages of the races, the sexes or the regions. There is no significant difference between the mean age of poisoning (31.5) and hanging (31.8). CONCLUSION: There is a significant racial difference in rates of suicide but the influences of region, age and method are relatively slight.

Adult↗
PubMed1996

Photophobia and lithium.

CLINICAL PICTURE: We report the case of a 45 year old woman who developed photophobia after 6 months on lithium at non-toxic levels. TREATMENT AND OUTCOME: Lithium was reintroduced twice and on both occasions this side-effect reoccurred within days. CONCLUSIONS: Photophobia has only been described previously as a symptom of lithium intoxication.

Antimanic Agents↗
PubMed1995

Victims of violence in Fiji.

OBJECTIVE: The aim of the paper is to examine the statistics for violence performed by self or others in Fiji during the period 1969-1989 in the following sub-classifications: (1) fatal vs non-fatal; (2) Fijian vs Indian; and (3) male vs female. METHOD: Crude rates per 100,000 were determined and the data sets were statistically examined. RESULTS: (1) Violence by self, which includes suicide and non-fatal injury by self, has significantly increased; (2) Indian violence by self has increased in both males and females; (3) suicide is 4 times more common than homicide, whereas non-fatal injury by others is 4 times more common than non-fatal injury by self; (4) non-fatal injury by self is 8 times more common than suicide, whereas non-fatal injury by others is over 100 times more common than homicide; (5) Indian violence by self is 6 times more common than Fijian violence by self, whereas Fijians experience violence by others 2.5 times more commonly than Indians; (6) female violence by self is 1.5 times more common than male violence by self, whereas male violence by others is 3 times more common than female violence by others; (7) the rates of suicide and homicide are low by international standards; and (8) Fijian violence by self is particularly low, but consistent with the low suicide rate of the indigenous populations in surrounding geographical regions. CONCLUSION: Our findings suggest that racial differences in violence are likely to be due to cultural factors.

Cause of Death↗
PubMed1995

Hereditary spastic paraplegia with dementia.

OBJECTIVE: Hereditary spastic paraplegia (HSP) with dementia is a very rare condition. The aim of the paper is to present the first report of HSP in a Fijian Indian family. METHOD: A psychiatrist and a general physician examined the affected members of the family on five occasions over three years. RESULTS: There are three affected individuals in a sibship of seven. The parents are without symptoms and the marriage is non-consanguineous. The course of the disease has been remarkably similar. All subjects were healthy and performing well in the early years of school. In two, symptoms of cognitive loss preceded difficulty with ambulation and in the third, these symptoms appeared concurrently. All subjects had both symptoms by 13 years of age; they were unable to ambulate independently by the mid to late teens, at which time there was dysarthria spastic paraplegia and dementia. One subject suffered a three month episode of hypomanic behaviour. Over the three-year study period deterioration was slight but noticeable. CONCLUSIONS: It is possible that HSP is more commonly associated with pre-senile dementia than is currently recognised. HSP with dementia is a very rare cause of failing school performance. Physical examination of the patient and other family members is indicated if this diagnosis is being considered.

Adolescent↗
PubMed1994

Survival analysis and readmission in mood disorder.

BACKGROUND: This is an exploratory study of readmission in mood disorder. METHOD: The study is naturalistic and employs survival analysis. We identified 821 individuals with ICD-9 diagnoses, drawn from the Tasmanian Mental Health Register. RESULTS: No demographic variables influence the time to readmission. Two groups emerge: those with affective psychoses, and those with neurotic depression, brief depressive reaction and depressive disorders not elsewhere classified. The former group demonstrated shorter times to readmission than the latter. There was no support for a unipolar-bipolar distinction. CONCLUSIONS: Affective psychoses have a less favourable outcome than expected. There was support for an endogenous-neurotic distinction.

Adult↗
PubMed1992

The insanity defence.

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Commitment of Persons with Psychiatric Disorders↗
PubMed1989

Cloning and analysis of genes involved in coenzyme B12 biosynthesis in Pseudomonas denitrificans.

Cobalamin synthesis probably requires 20 to 30 different enzymatic steps. Pseudomonas putida and Agrobacterium tumefaciens mutants deficient in cobalamin synthesis (Cob have been isolated. In P. putida, Cob mutants were identified as being unable to use ethanolamine as a source of nitrogen in the absence of added cobalamin (deamination of ethanolamine requires coenzyme B12 as a cofactor). In A. tumefaciens, Cob mutants were simply screened for their reduced cobalamin synthesis. A genomic library of Pseudomonas denitrificans was constructed on a mobilizable wide-host-range vector. Eleven plasmids from this library were able to complement most of these mutants. By complementation and restriction mapping analysis, four genomic loci of P. denitrificans were found to be responsible for complementation of the Cob mutants. By subcloning fragments from the four genomic loci, we identified at least 14 different genes involved in cobalamin synthesis.

Cloning, Molecular↗