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Biomedical subjects

S Probst

Publications and source records attributed to S Probst.

24 records · Page 2Linked to original sources
PubMed1989

Antagonisation of fentanyl-induced respiratory depression by nalbuphine.

The opioid antagonistic efficacy of nalbuphine (20 mg i.v.) was determined in 11 healthy volunteers, who had received 10 micrograms/kg fentanyl ten minutes before. The mean respiratory minute volume decreased to 31.5% of baseline level after fentanyl and increased to 116.8% 2 min. after the administration of nalbuphine. PaCO2, PaO2 and pH values showed the typical clinical signs of respiratory depression and reached pre-fentanyl levels following nalbuphine. No significant hemodynamic changes were caused by the antagonisation. These results suggest that nalbuphine effectively and safely reverses the respiratory depressant effects of commonly used doses of fentanyl without causing hemodynamic side effects.

Adult↗
PubMed1984

Reversal by nalbuphine of respiratory depression caused by fentanyl.

In 60 ASA class I or II patients given intravenous fentanyl for elective operations in doses large enough to produce postoperative respiratory depression, the intravenous administration of 20 mg nalbuphine resulted in prompt reversal of respiratory depression without loss of analgesia.

Adult↗
PubMed1981

[Oral glucose tolerance tests--with or without estimation of serum insulin? (author's transl)].

Blood glucose and serum insulin values were determined after oral glucose tolerance tests in 528 persons with suspected pathological or disturbed glucose tolerance. Results were evaluated depending on sex, age, overweight, and familial diabetes. There were no differences of serum insulin secretion and behaviour of blood sugar between males and females. With increasing age there was a marked decrease of insulin secretion. In contrast there was increased hyperinsulinaemia with increasing overweight. This was particularly evident in persons with comparably reduced glucose tolerance but with different body weight. "Classical" changes of insulin secretion, as described for prediabetes and manifest diabetes in contrast to persons with normal metabolism, were only seen in selected groups of probands with normal weight. Serum insulin shows greater variability than blood glucose. Estimations of insulin are not necessary when assessing disturbances of glucose tolerance.

Administration, Oral↗
PubMedDate not supplied

Midazolam does not antagonize fentanyl-mediated analgesia in surgical patients.

STUDY OBJECTIVE: To determine whether midazolam possesses a clinically significant antianalgesic action in surgical patients. DESIGN: Randomized, controlled study. SETTING: Inpatient anesthesia at a university department of neurosurgery. PATIENTS: 2 groups of 10 patients each who were scheduled for supratentorial brain surgery, did not have elevated intracranial pressure, and were free from systemic disease. INTERVENTIONS: Patients underwent anesthesia induction with hexobarbital, succinylcholine, and pancuronium; anesthesia was maintained with injections of droperidol-fentanyl (Group 1) or with midazolam-fentanyl (Group 2) following a predetermined repetitive dosing schedule, such that fentanyl 0.1 mg was injected upon predominant increases in heart rate, whereas droperidol 2.5 mg or midazolam 2.5 mg was injected upon increases in blood pressure. MEASUREMENTS AND MAIN RESULTS: Duration of anesthesia and invasiveness of surgery were similar in both groups. The amount of fentanyl required was 0.55 +/- 0.18 mg/hr (mean +/- SD) in Group 1 and 0.53 +/- 0.17 mg/hr in Group 2. Injections of droperidol 7.5 +/- 3.4 mg/hr (Group 1) and midazolam 5.9 +/- 2.3 mg/hr (Group 2) were administered intraoperatively. This redosing regimen was associated with uninterrupted hemodynamic stability, indicating comparable and adequate anesthetic depth. Plasma concentrations of metabolites and hormones indicative of humoral stress activation did not differ between groups. CONCLUSION: Under these clinical conditions, the administration of midazolam, when compared with droperidol, was not associated with signs of any antagonistic or antianalgesic action toward fentanyl-mediated analgesia.

Adolescent↗