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Biomedical subjects

S Proctor

Publications and source records attributed to S Proctor.

At least 37 records · Page 2Linked to original sources
PubMed1993

Randomised vehicle-controlled dose-finding study of glycosylated recombinant human granulocyte colony-stimulating factor after bone marrow transplantation.

A multicentre, randomised vehicle-controlled single-blind dose ranging trial of intravenous recombinant granulocyte colony-stimulating factor (rhuG-CSF) administration after BMT has been performed in 121 patients with non-myeloid malignancies. All the doses of rhuG-CSF used (2-20 micrograms/kg/day) resulted in significant acceleration of neutrophil recovery, and a dose-response effect was apparent (p < 0.05). At the 20 micrograms/kg/day dose of rhuG-CSF the median time taken to achieve a neutrophil count of > 0.5 x 10(9)/1 was reduced from 19 to 13 days (p < 0.001) and the time to achieve a neutrophil count > 1.0 x 10(9)/1 on the first of 3 consecutive days, from 26 to 14 days (p < 0.001). There was a trend to less antibiotic use in the rhuG-CSF recipients and the median time in hospital was markedly reduced by 11-15 days (p < 0.01). There was no toxicity in this study attributable to rhuG-CSF.

Adolescent↗
PubMed1992

What teachers want to know about students with cancer.

This article reports the results of a survey of classroom teachers in elementary and high schools in the San Francisco Bay Area. The teachers were asked to respond to questions about their informational needs and concerns related to students in their classroom who were diagnosed with cancer or receiving cancer treatment. Findings indicated that classroom teachers perceive themselves to be ill prepared to address the needs of the student with cancer. Specific concerns clustered around information deficits regarding the students' physiological and physical vulnerability, physical limitations/alterations following treatment, psychological responses to cancer treatment, and peer interactions. Utilizing data from the survey, a conceptual approach and collaborative intervention scheme were developed.

Humans↗
PubMed1990

Virus infections in bone marrow transplant recipients: a three year prospective study.

Over three years 81 consecutive bone marrow transplant recipients (32 allogeneic and 49 autologous) who received prophylaxis with acyclovir, were studied for symptomatic virus infection. Thirty nine infections were documented in a total of 28 patients. Thirty two infections were mild, five were moderately severe, and two were severe. Cytomegalovirus infection occurred in only six allogeneic recipients. Herpes simplex virus and varicella zoster virus infections occurred infrequently. Seven patients who were considered at the time of death to have died due to an infectious cause were studied virologically at necropsy. In only one patient was a virus infection thought to have been the cause of death. Prophylaxis with acyclovir may have influenced the rate and clinical prominence of herpes virus infections. In this study viruses were considered to have had a relatively minor role in causing morbidity and mortality.

Acyclovir↗
PubMed1987

Hard times--hard choices: positive decision-making for part-time women doctors.

In an increasingly competitive medical market-place, one of the authors had observed that women applying for training posts often appear lacking in self-confidence and unclear in decisions concerning their career plans. A successful workshop was held for women training part time which provided a forum for individuals to identify and explore their career dilemmas and an opportunity to make some quantitative assessment of their attitudes. Questionnaires completed by the 22 attenders and a further 16 returned by post showed that the majority of this group had realistically thought out career plans, had resolved the dilemmas posed by combining career and family commitments and were clear that their eventual career goal was to become a Consultant in the National Health Service. A much smaller group of women who tended to be both older and occupying more junior grades emerged as being confused about how the career/children conflict could be resolved and unclear as to their career aims. The oft-stated assumption that 'most women prefer a job with less responsibility than a Consultant' was not supported but it is clear that if women are not to be nudged into career cul-de-sacs they need clear advice and information so that they can complete their training and compete successfully with their male colleagues for career posts.

Attitude of Health Personnel↗
PubMed1986

Polymorphic reticulosis with oral lesions: a case report.

Polymorphic reticulosis is a rare lymphoproliferative disorder with a predilection for the upper respiratory tract. An unusual case with palatal, labial and lingual lesions is described and the value of radiotherapy, cytotoxic and steroid therapy in such cases is discussed.

Adult↗
PubMed1985

Deoxycoformycin in the treatment of leukemias and lymphomas.

A new cytotoxic drug, 2'-deoxycoformycin, has been shown to be highly active in the treatment of lymphocytic leukemias and lymphomas, particularly T cell acute lymphoblastic leukemia, in which the drug, used as a single agent, can induce CRs in patients who have failed to respond to a wide variety of other compounds. Further work is required to elucidate the cause of the renal failure that has occurred in some patients, but prescribed within the dose range of the patients reported in this paper, toxicity is acceptable in consideration of the results achieved and the prognosis of this highly malignant group of diseases.

Acute Kidney Injury↗
PubMed1983

Enrichment and depletion of thyroglobulin autoantibody synthesizing lymphocytes.

Lymphocyte populations enriched for (or depleted of) a receptor for thyroglobulin (Tg) have been prepared from Hashimoto peripheral blood mononuclear cells (PBM) by rosetting with Tg coated erythrocytes. Removal of Tg binding cells from PBM or B cell preparations resulted in greater than 85% reduction in their ability to synthesize Tg antibody when stimulated with pokeweed mitogen (PWM) or EB virus (EBV); the depletion was specific since the ability of Tg receptor negative cells to secrete microsomal antibody and total IgG was unimpaired. Hashimoto lymphocytes (PBM or B cells) enriched for Tg binding cells produced only small amounts of Tg antibody when cultured with PWM even in the presence of irradiated T cells and monocytes; exposure to autoantigen followed by mitogen appeared to be inhibitory. However, the Tg receptor positive fraction was readily activated by EBV to synthesize Tg antibody with a specific activity 4-10 times higher than that secreted by unfractionated lymphocytes. The ability to isolate Tg specific B cells from peripheral blood will facilitate the development of EBV transformed cell lines secreting monoclonal Tg antibody and such antibodies will provide invaluable probes in the investigation of autoimmune thyroid disease.

Aged↗
PubMed1980

Anti-endotoxin (anti-lipid-A) antibodies.

Anti-lipid-A, anti-endotoxin, antibodies have been measured by a passive haemolysis test using antigen from an E. coli Re mutant. Titres in the normal population are low but do rise in situations in which there has been gram-negative sepsis. Absence of raised titres in other situations has profound implications.

Animals↗