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Biomedical subjects

S Prosser

Publications and source records attributed to S Prosser.

52 records · Page 3Linked to original sources
PubMedDate not supplied

Audiometric patterns of genetic non-syndromal sensorineural hearing loss.

Sixty-five families with non-syndromal sensorineural hearing loss (NS-SNHL) of genetic aetiology were subtyped according to Gorlin et al. Individual audiogram shapes were also classified in order to detect inter- and intra-familial variations. In 48 families with an Autosomal Dominant (AD) inherited form, 26 exhibited the features of (high-frequency) progressive NS-SNHL, 12 those of mid-frequency NS-SNHL, 5 were affected by congenital low-frequency NS-SNHL; 1 kindred showed a progressive low-frequency pattern and another 1 a unilateral NS-SNHL; only 3 kindreds were affected by severe congenital NS-SNHL. Autosomal Recessive (AR) inherited forms were composed of 9 kindreds with severe congenital NS-SNHL, and 7 with moderate congenital NS-SNHL. One X-linked form was identified. AD- and AR-inherited NS-SNHL differed significantly both in severity of hearing impairment and in audiogram shapes. With few exceptions, in each family classified according to Gorlin, most of the affected subjects shared the same audiogram profile. Intrinsic progression of the disease versus ageing was studied in the larger subtype of individuals with the high-frequency loss. Gorlin's classification still remains the best system to classify NS-SNHL, and can provide a broad base to separate a very heterogeneous group of disorders. Results obtained in gene mapping in single large human families or in homologous gene search could be tested in our families. For some of them, namely those with high frequency progressive and low-frequency NS-SNHL, testing should already be feasible.

Adult↗
PubMedDate not supplied

Mobility screening in the elderly and resulting referral.

The aims of this study were to test the usefulness of the Royal College of General Practitioners' (RCGP) mobility screening questionnaire in Irish general practice and to use it to assess the level of mobility problems in the over-75 year old population. Questionnaire screening survey in six faculty areas of the Irish College of General Practitioners(ICGP) well-spread geographically to be representative of the Irish population. Participants were a random sample of 627 people aged 75 years or over, from the General Medical Services list of 92 volunteer general practitioners. The Royal College of General Practitioners' screening questionnaire for mobility was administered by each person's doctor. Suggested interventions were also noted. 92% felt able to get around the house independently, with 78% able to manage stairs independently. The commonest aid to mobility was a stick, used by 27%. Mental impairment was closely associated with inability to get around the house (86% of those not independent around the house scored less than 8 on the Abbreviated Mental Test Score). Analysis of referral patterns indicated possible deficiencies in the availability of physiotherapy in certain areas. The RCGP mobility screening questionnaire was easy to use, and helpful in detecting problems which might require attention.

Aged↗
PubMedDate not supplied

Nature of lysozyme-water interactions by proton NMR.

Proton spin-lattice relaxation measurements were performed in 10 mM lysozyme solution as a function of temperature and degree of substitution of solvent H2O with D2O. The results show that in the temperature range from 274 to 323 K, the intermolecular lysozyme proton water proton coupling contributes appreciably to the observed water proton relaxation rate. In this system exchange between water protons and labile protein protons does not dominate the behaviour with temperature of the water-lysozyme intermolecular contribution to the spin-lattice relaxation.

Kinetics↗
PubMedDate not supplied

[New therapeutic prospects in acute acoustic trauma].

A total of 50 young soldiers hospitalized for high frequency hearing loss and tinnitus following exposure to gun impulse noise was studied in order to ascertain the effects of two kinds of medical treatment. A first group (18 subjects) was treated for 10 consecutive days with cerebral gangliosides. In a second group (17 subjects) gangliosides were associated with subcutaneous infiltration of bupivacaine chlorhydrate (0.5%). A third group (15 subjects) was taken as control. An improvement in hearing threshold (= greater than 20 dB at 4-8 kHz) and a consistent relief of tinnitus was respectively found in 52% and 66% of the treated subjects, while hearing status and tinnitus persisted unchanged among the control group subjects. The amount of hearing improvement over the control group proved to be statistically significant, although no significant difference was demonstrated between the two kinds of medical treatment. Since therapy was initiated 5 to 21 days after acoustic trauma, these results indicate that a pharmacological treatment may be effective even in cases where diagnosis is forwarded relatively late in respect to the trauma.

Adult↗
PubMedDate not supplied

[Quantitative abnormalities in nystagmus induced by caloric stimulation in multiple sclerosis].

Vestibular nystagmus induced by caloric stimulation (20 degrees and 44 degrees C) was evaluated in terms of duration, frequency and slow phase velocity in 80 patients suffering from clinically defined multiple sclerosis. Criteria of abnormality were established with reference to 3 confidence levels from normative data of a 15-subject control group. Abnormal data representative of vestibular hypo- and hyperreflexia were found ranging between 27 and 53% depending on different parameters and diagnostic criteria. Significant differences in occurrence of nystagmus abnormalities became evident by analyzing 6 different windows of the vestibular response. Different distributions of hypo- and hyperreflexia were observed in relation to the time-course of the normal cumulative response curve, as well as to different stimulus temperatures. For each subject the abnormal data of the 2 stimulated ears X 2 caloric stimulations X 6 analysis windows were cumulated, yielding an overall outcome of pathological results in 66% to 90% of the patients, depending on the different diagnostic criteria.

Adolescent↗
PubMedDate not supplied

[Bisyllabic words for speech audiometry: a new italian material].

Bisyllabic words are the most frequently used italian speech material in evaluating intelligibility function. The italian words presently used are those proposed by Bocca and Pellegrini in 1950. The Lists of these words do, however, present some problems with regard to phonemic balance and word familiarity. In speech audiometry testing, Lists are considered interchangeable if each individual List has the same phonemic balance. So as to avoid incorrect identification due to incomprehension of infrequently used words, we chose 200 of the most familiar bisyllabic words from the most recent, widely used occurrence vocabulary of the Italian Language. Secondly, we proceeded with phonemic balance of the speech material. The selected words were divided into ten lists of 20 words each, arranged in order to obtain the best phonemic balance within each individual List and among different Lists. The differences between the new and old speech material are presented and discussed.

Audiometry, Speech↗
PubMedDate not supplied

[Aspects of auditory short-term memory according to a multimodal sequence paradigm].

Capacity and temporal characteristics of auditory short-term memory have been investigated through a simple multi-tonal sequence paradigm in five normally hearing subjects. They were required to judge whether the tonal sequence contained or not a tone probe following the sequence. Performance was evaluated relative to the sequence length (2, 4, 6 stimuli) and sequence-probe interval (1, 3, 6 s.). The subjects' performance has been proven to be mainly dependent on the number of the sequence components (90% of the explained variance), while sequence-probe interval represents a factor of minor weight. Furthermore, a strong recency effect has been shown for the last sequence component, extending to the preceding components in dependence of the sequence-probe interval. Contrasting to studies on the verbal short-term memory, a primary effect has been not demonstrated. As these results reflect the typical effects of auditory short-term memory, it is likely that memory tests based on simple tonal sequences may be suitable for clinical use.

Acoustic Stimulation↗
PubMedDate not supplied

[The quantitative effects of competition on verbal intelligibility in the elderly].

The Speech Reception Threshold (SRT) was adaptively measured using sentences in two groups of subjects: young, normal-hearing subjects and elderly hearing-impaired subjects with high frequency loss. SRT was recorded in quiet and in noisy conditions with competition consisting in "speech noise" and continuous discourse delivered at intensities between 11.4 and 98.6 dBA SPL. A significant difference was found between the groups in that elderly subjects had higher SRTs in noise than the young counterparts expressed as signal to noise (s/n) ratio. Moreover, at noise intensities typical of everyday life, the SRTs of the elderly is 6 and 11.4 dBs/n higher than normal-hearing subjects, with speech noise and discourse respectively as competition. Communicative strategies that enhance s/n ratio should be considered in order to overcome the heavy effects of hearing loss in the elderly.

Adult↗