Glucose tolerance and coronary heart disease: Helsinki policemen study.
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Biomedical subjects
Publications and source records attributed to S Punsar.
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Relationships of drinking water quality to CHD and sudden death were studied in two rural areas in western and eastern Finland. In the eastern area, drinking water is particularly soft and contains less magnesium and chromium but more copper than in the western area. A 15-year follow-up of resident males showed a higher death rate from CHD in the eastern area but no difference in the proportion of sudden deaths. The data suggest that CHD may be associated with low concentrations of magnesium and chromium in the drinking water, but no definite relationship was found between water quality and sudden death.
Smoking habits and random measurements of the proportion of haemoglobin bound to carbon monoxide (COHb%) were examined for their association with atherosclerotic diseases in 1068 men aged 55 to 74 years from rural areas of Finland. COHb% and smoking history were similarly associated with claudication and coronary heart disease. Random measurements of COHb% did not show a better overall relation to the prevalence of atherosclerotic diseases than smoking history, though COHb% showed a stronger association with a probable previous myocardial infarction. Further studies are needed to clarify the role of carbon monoxide in atherosclerosis.
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The occurrence of notching in the initial and terminal parts of the QRS complex of the ECG was studied in a series of 1072 patients with active or healed pulmonary tuberculosis. Terminal notchings were associated with ventilatory impairment: in the male group the percentage of patients with terminal notching increased from 5 to 20% as the FEV1.0% decreased from larger than or equal to 80 to below 40. Initial notchings were not associated with ventilatory impairment. The relationships were similar when studied separately in groups with and without left heart disease.
The urinary exretion of chromium was studied for relationships to atherosclerotic diseases in two rural Finnish male populations, aged 55 to 74; one from eastern Finland, the other from the southwestern part of the country. A 10-year follow-up had shown a particularly high mortality from coronary heart disease in the eastern area where the concentrations of chromium in the drinking water were lower than in the western area. The 24-hr urinary excretions of chromium of the two populations were markedly low (east, mean +/- SEM, 3.60 +/- 0.15 microgram; west, 3.74 +/- 0.13 microgram), suggesting a suboptimal chromium intake in both populations. No consistent differences were found in urinary chromium excretions between groups with atherosclerotic diseases and reference groups. The role of low chromium intake in the pathogenesis of atherosclerosis deserves further study.
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