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S R Allegra

Publications and source records attributed to S R Allegra.

14 recordsLinked to original sources
PubMed1984

Crescentic IgA nephropathy.

We report five cases of crescentic IgA nephropathy. All are males, 16-60 years of age. One case each came to medical attention with uremia, nephrotic syndrome, and gross hematuria; two cases presented with microhematuria and proteinuria on routine urinalysis. All had hypertension, azotemia (serum creatinine 1.6-9.4 mg/dl), proteinuria (greater than 6 g/24 hr in four cases), hypoalbuminemia (less than 3 g/dl), and hematuria (gross in two cases). All progressed to end-stage renal failure renal failure ending in dialysis (three cases) or death from unrelated causes (two cases). Prednisone, 60 mg/day for 1 month in two patients (with two 1-g doses of iv methylprednisolone in 1 case) did not improve the serum creatinine level, but one patient subsequently experienced a less rapid fall in renal function. A crescentic glomerulonephritis was present in all biopsies (crescents in 31-80% of glomeruli; mean, 50%). The size and stage of the crescents were variable. Numerous glomeruli had focal or diffuse sclerosis. In all cases, there was a 3 or 4+ deposition of IgA. Low-intensity staining for IgG and IgM was noted in four and three patients, respectively. On electron microscopy, dense granular mesangial deposits were noted in all cases and in four patients capillary subepithelial deposits were also observed. This form of IgA nephropathy is not common, but some studies indicate that it may occur in about 5% of patients with IgA nephropathy.

Adolescent↗
PubMed1984

Acquired immune deficiency syndrome (AIDS). Light microscopic, ultrastructural and immunocytochemical studies of one case.

The lung and axillary lymph node biopsies of a 33-year-old male drug-abuser with clinical and immunologic evidences of AIDS were studied by light and electron microscopy. Encysted Pneumocystis carinii organisms with attached membranous expansions and virus-like particles were demonstrated in the alveolar spaces and, occasionally, in macrophages. The lymph node biopsy revealed areas of angioimmunoblastic proliferation associated with lymphocytic depletion of the interfollicular zones. Tubuloreticular structures (TRS) were prominent in lymphocytes and endothelial cells. Test-tube and ring-shaped forms (TRF) were less frequently seen and were present only in lymphocytes and immunoblasts. The combination of TRS and TRF appears to be an useful marker for AIDS. The possible significance of the angioimmunoblastic changes observed in the lymph nodes is also discussed.

Acquired Immunodeficiency Syndrome↗
PubMed1983

Endocrine activity in a large hibernoma.

Light, ultrastructural, biochemical and histochemical analyses of a large hibernoma revealed endocrine-like secretory activity. By biochemical and gas chromatographic analyses, cholesterol and steroid hormones were detected. These findings were confirmed by detection of cortisol and testosterone, radioimmune assay, and immunocytochemical testing. Morphologic evidence of endocrine-like secretory activity was provided by both transmission and scanning electron microscopic examination, which, in addition, revealed unusual features that have not previously been described for hibernomas: 1) "endoplasmacrine" lipid granule secretion, 2) rows of pedunculated or detached plasmalemmal granules in perisinusoidal cells, 3) periodic plasmalemmal densities, which were present also along membrane remnants surrounding lipid granules, and 4) highly innervated interstitial veins with eccentric lumens and peculiar thick muscular coats, which resembled structures seen in humans only in the central vein of the adrenal gland.

Adult↗