PubMed Health⌕ Search

Biomedical subjects

S R Andersen

Publications and source records attributed to S R Andersen.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Ophthalmopathologic findings in bog victims].

More than 1800 corpses found in European bogs have been described. Most were found in northwest Germany and Denmark. The 2700-year-old corpse of a young woman found in the Borremose fen in Denmark is described. The face was crushed, though injury during cutting of the peat was ruled out. Light and scanning electron microscopy revealed vessels both in the choroid of one eye and in one ear, with intravascular corpuscles--probably erythrocytes--but no extravascular hemorrhage. This means that the face was almost certainly crushed post mortem and during the winter. The cause of death is unknown. Very few of the other bog finds in Europe are well preserved, and even fewer have been pathologically studied or radiocarbon-dated. Interpretation of their fate is a very difficult, complex problem. One reason for this is that the corpses often remained buried for several thousand years, and they are often poorly preserved. The first descriptions of it were Roman, in particular Tacitus' Germania, which appeared in 98 AD--it is thus much younger than most of the corpses so far found. Tacitus talks of hanging, drowning, and ritual sacrifices. As regards future bog finds, it is suggested that an archaeologist, an anthropologist, a forensic expert and a taxi-dermist should be called in as soon as excavation begins. International cooperation between experts could prove very fruitful.

Adult↗
PubMed1985

Senile macular degeneration. Results of laser treatment. A preliminary report.

A preliminary report on laser treatment of senile macular degeneration is presented. Over a one year period 234 patients with symptoms and signs of macular degeneration were examined with fluorescein angiography. 32 patients (14%) showed neovascular membranes accessible to treatment with blue/green argon laser. At the end of the observation period (mean 8.7 months) one half of the treated group had unchanged or better visual acuity, whereas the other half showed deterioration of the visual acuity. It is not known whether this result differs from the average spontaneous course. A controlled trial is necessary in order to evaluate the possible beneficial effect of laser treatment of senile macular degeneration in our population.

Adult↗
PubMed1983

Histopathology in botryomycosis-like panophthalmitis due to Staphylococcus aureus. A light microscopic and electron microscopic study. A case report.

A Swedish farmer's wife aged 46 developed a unilateral panophthalmitis 6 weeks after a visit to Gambia in Africa. Vitreous puncture revealed growth of Staphylococcus aureus, but in spite of adequate treatment the eye had to be enucleated 5 weeks after the onset of symptoms. Gram-positive microorganisms in botryomycosis-like granules in the vitreal abscesses were at first suspected to be Histoplasma capsulatum. Electron microscopic examination revealed microorganisms, consistent with staphylococci. There was extensive proliferation of mesosomes, most probably due to the intense treatment. The poor nutrition and slow resorption of the dead microorganisms from the avascular vitreous did possibly also play a part in the proliferation of the mesosomes.

Anti-Bacterial Agents↗
PubMed1981

Human skin reaction to ethylene oxide.

Many materials now used in hospitals are sterilized with EO. EO gas retained in porous materials, which have not been properly aired, can produce skin irritation. The experiments reported here were designed to determine the level of EO and duration of skin contact required to produce adverse effects. The role of EO by-products in such reactions was also investigated. To obtain this information, patches retaining EO or its by-products, EC and EG, were applied to the backs of human volunteers. The patches were removed at intervals between 1 and 8 hr and the reactions were observed. The resulting skin reactions directly related to the total dose of EO received. Patch materials that rapidly lose EO, such as fabric or rubber, produced few reactions, even at EO levels as high as 5000 ppm. A patch material that loses EO more slowly, PVC film, produced reactions at EO levels above 1700 ppm. The patch materials that retained EO the longest, thick PVC blocks and petrolatum applied to Webril pads, produced the most reactions. When the EO level in those materials approximated 1000 ppm or higher, skin reactions usually appeared after 4 to 8 hr contact. The level of reactivity among the volunteers was quite consistent. One subject, however, who developed sensitivity to EO, showed a mild delayed reaction to approximately 100 ppm of EO in PVC. The characteristics of that sensitivity are discussed. Since little or no reactions developed to the patches containing EO by-products, EO itself can be assumed to be the toxic agent. The experiments support the conclusion that the lowest level of EO which produces skin irritation in nonsensitized subjects approximates 1000 ppm, when retained in slow-airing material against the skin for 4 hr or more.

Clothing↗
PubMed1978

Uveitis in rabbits with pleural effusion disease. Clinical and histopathological observations.

Pleural effusion disease (PED) is a generalized infection of laboratory rabbits caused by a virus-like agent. The disease was first described in the late sixties as a mortality problem among rabbits used for the propagation of Nichols' pathogenic Treponema pallidum in Scandinavian laboratories using the T. pallidum immobilization (TPI) test for the serological diagnosis of syphilis. The iridocyclitis, described as a manifestation of PED, has been studied in detail in rabbits experimentally infected with the PED agent. All rabbits surviving the acute phase of infection developed a non-pyogenic, non-granulomatous anterior uveitis during the "viraemic" stage of infection. The ocular signs of disease culminated between days 3 and 6 and disappeared within 2 to 3 weeks. No recurrence of uveitis was observed during a 6-months observation period, nor by subsequent subcutaneous re-inoculation of the PED agent. Histologically, the uveal reaction was mild and regressed almost completely within 4 weeks. Discrete choroidal inflammatory foci occurred in some of the re-inoculated rabbits, but without changes in the anterior eye segment. The uveitis of pleural effusion disease in rabbits seems to be caused directly by the virus-like agent. It might possibly serve as a simple and reproducible model in further uveitis research.

Animals↗
PubMed1977

Aniridia, cataract and gonadoblastoma in a mentally retarded girl with deletion of chromosome II. A clinicopathological case report.

A case of bilateral aniridia, cataract and mental deficiency is described in a girl with an interstitial deletion of the short arm of chromosome 11. The child died of pneumonia and on autopsy bilateral gonadoblastoma was detected, but no Wilms' tumour. Partial deletion of the short arm of chromosome 11 seems to be a clinically recognizable syndrome with aniridia, cataract and renal, gonadal or genital dysmorphogenesis.

Cataract↗