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Biomedical subjects

S R Bhusnurmath

Publications and source records attributed to S R Bhusnurmath.

At least 37 records · Page 2Linked to original sources
PubMed1990

Prevention of malaria-induced foetal abnormalities following immunization of mice with Plasmodium berghei merozoite antigen.

Pre-pregnancy immunization of Swiss albino mice with merozoite antigen of P. berghei entrapped in multilamellar phosphatidyl choline liposomes resulted in (i) increased prepatent period, (ii) either no or low parasitaemic levels, (iii) reduced mortality, and (iv) normal foetal and placental development, upon challenge with P. berghei on 13th gestational day. The unimmunized animals which received either phosphate buffered saline or empty multilamellar phosphatidyl choline liposomes before pregnancy developed high parasitaemic and 30-40 per cent animals died before parturition while 60-70 per cent unimmunized animals revealed foetal abnormalities such as low body weight and larger spleen size. Placentae of unprotected animals had hyperplasia of trophoblastic membrane and plugging of placental sinusoids with parasitized erythrocytes and malarial pigments. The data suggest that prior immunization of animals with merozoite antigen entrapped in multilamellar phosphatidyl choline liposomes could abrogate the ill effects induced by malaria infection under the stress of pregnancy.

Animals↗
PubMed1989

Effect of silica treatment on histopathology of intestinal & hepatic amoebiasis in murine model.

Histopathological changes in intestinal and hepatic amoebiasis were studied in Swiss albine mice with and without silica pretreatment. The intestinal infection rate was higher in silica treated mice (83%) as compared to non-silica treated mice (33%). Histologically all the silica treated mice had caecal ulceration which tended to spread across the muscularis propria into the serosal layer. The hepatic lesions were observed grossly in 100 and 60 per cent mice with and without silica treatment, respectively. However, the liver lesions in the silica treated mice were more severe, leading to satellite abscesses and in some cases the capsule ruptured leading to adhesions to the diaphragm and peritoneum. Histologically, the blockade of histiocytes with silica resulted in mainly a neutrophilic damage which was extensive and widespread. It also destroyed the amoeba and led to abundant fibrosis. In the non-silica group the damage was slow and devoid of neutrophils with quicker healing and lack of fibrosis resembling human hepatic lesions.

Animals↗
PubMed1989

Ureteral involvement in stage I xanthogranulomatous pyelonephritis--(a case report).

A case of xanthogranulomatous pyelonephritis (Stage-I: Nephric) with ureteral involvement is described. The patient had undergone right nephrectomy with the working diagnosis of calculus pyonephrosis and non-functioning kidney. Histopathological examination of the nephrectomy specimen revealed xanthogranulomatous pyelonephritis confined to the kidney and non-contiguous involvement of ureter. Post-operative recovery was uneventful and there had been no evidence of disease recurrence till one year's follow-up.

Humans↗
PubMed1988

Acute renal failure following multiple hornet stings.

Five patients who developed acute renal failure due to acute tubular necrosis following multiple hornet (Vespa orientalis) stings are described. All of them had intravascular hemolysis. Evidence for rhabdomyolysis was present in 2 patients. Two patients had elevated transaminase and alkaline phosphatase levels and in 1 of these, liver biopsy showed centrilobular necrosis. Two patients had thrombocytopenia in the absence of disseminated intravascular coagulation. Two patients died of infections while the remaining 3 recovered completely. Acute renal failure following multiple hornet stings appears to result mainly from intravascular hemolysis or rhabdomyolysis although a direct nephrotoxic effect of venom cannot be excluded.

Acute Kidney Injury↗
PubMed1987

Adult onset Still's disease in North India. A report on six patients.

Six patients suffering from adult onset of Still's disease were seen over a 10-year period. Contrary to expectations, complications of deformative arthritis (two patients), amyloidosis (one patient), uveitis (one patient) and chronic granulomatous liver disease (one patient) were observed during follow-up. One patient succumbed due to iatrogenic causes; autopsy showed that the pathological changes, like the clinical features, were non-specific. Four patients responded to aspirin and indomethacin; two required corticosteroids.

Adolescent↗
PubMed1987

Wegener's granulomatosis in north India. An analysis of eleven patients.

Eleven patients with Wegener's granulomatosis were seen at this Institute over a period of 20 years. There were six men and five women. The average age of presentation was 38.3 years, and the mean duration of symptoms was 10.5 months. Constitutional symptoms (82%), cough (82%), ocular symptoms (64%), arthralgias (55%), rhinorrhoea (55%), haemoptysis (45%), nasal granuloma (45%), otorrhoea (36%), sinusitis (36%), skin lesions (27%), and renal failure (27%) were the clinical manifestations encountered. All patients had an elevated ESR, and 55% had leucocytosis. Proteinuria and haematuria were observed in 64% and 55% respectively. Chest radiographs were abnormal in 82%. In four patients the disease had a fulminant course and the patients died before adequate treatment was given. Two patients received corticosteroids alone and have since been lost to follow up. Five (45%) received adequate cytotoxic therapy and have done well for 8-46 months (mean, 24.8 months) after diagnosis. Wegener's granulomatosis in India is apparently similar to that seen elsewhere, but the high incidence of tuberculosis interferes with early diagnosis and treatment.

Adolescent↗
PubMed1986

Antibodies to HTLV-I in Nigerian blood-donors, their relatives and patients with leukaemias, lymphomas and other diseases.

Antibodies to HTLV-I have been detected in sera from 15 (2.0%) of 736 adult blood-donors in Nigeria, in 4 (20.0%) of 20 patients with chronic lymphatic leukaemia, 3 (10.0%) of 30 with non-Hodgkin's lymphoma, one of 12 with Burkitt's lymphoma and one of 7 with acute lymphoblastic leukaemia. The frequency of positivity was higher (3.6%) in the blood-donors from the guinea and wooded savanna of northern Nigeria than in those from the rain-forest and mangrove swamps of southern Nigeria (1.8% in Lagos and 0.7% in Calabar). Two of the 3 seropositive patients with lymphoma had clinical presentation and courses similar to those of Japanese and Caribbean patients with adult T-cell leukaemia/lymphoma.

Antibodies, Viral↗
PubMed1986

Cytology of hepatocellular carcinoma.

Twenty-five cases of cytologically and histologically confirmed hepatocellular carcinoma (HCC) were cytomorphologically analyzed using May-Grünwald-Giemsa (MGG)-stained aspiration smears and supplemented with special stains. The cell types were categorized as well differentiated (18 cases), vacuolated (four cases), giant cell (one case), and poorly differentiated (two cases). Glycogen staining was positive in 80% of the cases and hence served as a reliable parameter of diagnostic importance in HCC. Cytoplasmic hyaline bodies (14.6%) and bile pigment (17%), when present, were other important features supporting the diagnosis of HCC. Vacuolation of the cell cytoplasm (80%) was possibly related to glycogen accumulation. The cause of nuclear vacuolation (60%) and the significance of nuclear argyrophilia as markers of abnormal cell growth remain to be studied.

Adolescent↗
PubMed1986

Acute toxicity studies with Jatropha curcas L.

The seeds of Jatropha curcas L. ingested accidentally by two children aged 3 and 5 years led to a clinical syndrome of restlessness, severe vomiting and dehydration. A systematic study of the seeds indicated that they produced toxic effects in mice. Macroscopic anal haemorrhage and death occurred when the seeds were administered with the feed. Post-mortem examination revealed infarction of various parts of the gastrointestinal tract with congested vessels. Sodium chloride solution (150 mmol/l: saline) extract of the dried seed administered intraperitoneally into mice caused death in doses as low as 1 mg/kg. Post-mortem studies in this case showed widespread haemorrhages involving the colon, lungs as well as infarction of the liver. Larger intraperitoneal doses (greater than 30 mg/kg) were lethal rapidly but not associated with gross gastrointestinal haemorrhage.

Animals↗
PubMed1985

Histopathology of hepatic amoebiasis in guinea-pigs infected through intracaecal and intramesenteric routes.

The comparative histopathological details of amoebic liver abscess were studied following intracaecal and intramesenteric inoculation of Entamoeba histolytica into guinea-pigs. The histological changes of amoebic liver abscess formed via the former route were similar to those seen in man. These consisted of a central necrotic area with few lymphomononuclear cells and E. histolytica trophozoites at the periphery of the lesion. The amoebic liver abscess formed via the intramesenteric route, however, differed from that formed by intracaecal inoculation in three ways: (i) in having an intense inflammatory reaction, (ii) healing of the abscess by fibrosis and (iii) exhibiting a giant cell reaction.

Animals↗