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S R Fargion

Publications and source records attributed to S R Fargion.

7 recordsLinked to original sources
PubMed1976

Rosette inhibition test in chronic liver disease.

A role has recently been assigned to cell-mediated immunity in chronic liver diseases in addition to the well-known alterations of humoral immunity. We now report the results of the rosette inhibition test for the evaluation of T-lymphocyte "sensitization" in patients with different chronic liver disorders. A cell-mediated immune reaction was found in 81% of patients with chronic active hepatitis and in 71% with primary biliary cirrhosis, whereas patients with chronic persistent hepatitis showed no reaction. The correlation with the incidence of hepatitis B antigen showed that T-lymphocyte sensitization was more frequent in the group of HB-positive patients. Finally, improvement of the test was observed in four out of nine patients given immunosuppressive treatment.

B-Lymphocytes↗
PubMed1975

[Aspects of humoral immunity in ulcerous colitis].

Various immunological indices, hitherto considered in isolation, were evaluated in a single group of 20 cases of ulcerous colitis. Immunofluorescence showed anticolon Ab in 3 cases (15%), whereas this features was absent in a control group. Antistomach, antithyroid and non-organ-specific Ab's (ANA, AMA, SMA) were equally incident in both groups. One caso is examined separately on account of its simultaneous presentation of human and rat antistomach and antithyroid and antismooth muscle Ab's. Reuma test, Waaler Roose reaction, L.E. phenomenon and test, and direct and indirect Coombs test results were negative in nearly all cases. Slight quantitative changes in serum proteins revealed by electrophoresis and immunodiffusion were indicative of inflammation with an immunitary tendency. The data are not sufficient to support the attribution of an autoimmunitary aetiology to ulcerous colitis, though simultaneous evaluation of reaction indices serves to strengthen this view.

Adolescent↗