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Biomedical subjects

S R Garfin

Publications and source records attributed to S R Garfin.

At least 19 recordsLinked to original sources
PubMed1992

Effects of reperfusion intervals on skeletal muscle injury beneath and distal to a pneumatic tourniquet.

To date there have been no experimental studies specifically directed at effects of reperfusion intervals on skeletal muscle injury beneath the tourniquet. 99mTechnetium pyrophosphate (Tc 99) incorporation and correlative histology were used to assess injury 2 days after tourniquet application in muscles beneath (thigh) and distal (leg) to the cuff. Tourniquets were applied to rabbit hindlimbs for a total of either 2 or 4 hours. In the 4-hour series, tourniquet compression (either 125 mm Hg or 350 mm Hg cuff inflation pressure) was either continuous or interrupted by 10-minute reperfusion intervals after 2 hours or after every hour of cuff inflation. In the 2-hour series, tourniquet compression (350 mm Hg) was either continuous or interrupted by 10-minute reperfusion intervals after 2 hours or after every hour of cuff inflation. In the 2-hour series, tourniquet compression (350 mm Hg) was either continuous or interrupted by a 10-minute reperfusion interval after 1 hour. Pyrophosphate incorporation (Tc 99 uptake) was significantly greater in the thigh region than in the leg region in all of the 4-hour tourniquet groups. Tc 99 uptake was significantly reduced by reperfusion after each hour of cuff inflation. With 350 mm Hg tourniquet pressure, a reperfusion interval after 2 hours of cuff inflation tended to exacerbate tourniquet compression injury. Reperfusion intervals did not significantly affect Tc 99 uptake in the leg region of these groups. With a 2-hour tourniquet time, Tc 99 uptake in the thigh was significantly decreased by reperfusion after 1 hour of cuff inflation. Previous clinical recommendations, based on serum creatine phosphokinase abnormalities after experimental tourniquet ischemia, probably reflected tourniquet compression injury. Hourly reperfusion limits skeletal muscle injury during extended periods of tourniquet use.

Animals↗
PubMed1992

Effects of magnitude and duration of compression on spinal nerve root conduction.

Spinal nerve root compression occurs commonly in conditions such as herniated nucleus pulposus, spinal stenosis, and trauma. However, the pathophysiology of the symptoms and signs related to spinal nerve root compression is poorly understood. The purpose of the present study was to assess and compare effects of various pressures and durations of acute compression on spinal nerve root conduction in the pig cauda equina. Efferent conduction (compound motor action potentials) and afferent conduction (compound nerve action potentials) were monitored during compression for 2 or 4 hours with compression pressures of 0 (sham), 50, 100, or 200 mm Hg. Recovery from compression was monitored for 1.5 hours. No significant deficits in spinal nerve root conduction were observed with 0 or 50 mm Hg compression, compared to significant conduction deficits induced by 100 and 200 mm Hg compression. Three-way analysis of variance demonstrated significant effects of compression pressure and duration on conduction at the end of compression and recovery, with a significant difference between efferent and afferent conduction at the end of the recovery period. These observations suggest an interaction between biomechanical and microvascular mechanisms in the production of nerve root conduction deficits. Such information may relate to the motor and sensory dysfunction in clinical conditions associated with spinal nerve root compression.

Action Potentials↗
PubMed1992

Screw fixation in the human sacrum. An in vitro study of the biomechanics of fixation.

A load-to-failure test was used to study the biomechanical properties of sacral screw fixation in human cadaveric specimens. The goals of this study were 1) to determine the effects of the two commonly chosen sacral screw orientations of fixation characteristics; 2) to determine the effects of selected screw-instrumentation linkages on the biomechanics of sacral screw fixation; 3) to correlate the biomechanical properties with a noninvasive assessment of sacral bone density; and 4) to correlate the torque during screw insertion with these biomechanical properties. The bone density of each specimen was measured with quantitative computed tomography. A screw was inserted from the dorsal surface either anteromedially or anterolaterally into the body of S1, and the torque needed to insert each screw was measured. The screw head was attached to a constrained or semiconstrained loading linkage. Force was applied to the screw in an inferior direction until the maximum load was achieved. The maximum load, screw translation, rotation at maximum load, and initial compliance of the bone-screw interface were determined. It was found that the anteromedial screw orientation, combined with a rigidly constrained loading linkage, resulted in the greatest maximum load to failure, the least screw rotation, and the least initial compliance of the four groups studied. The maximum load and the initial stiffness of bone-screw fixation increased significantly with bone density. Torque measurements correlated significantly with maximum load to failure, initial interface stiffness, and bone density. It was therefore concluded that bone density and torque measurements can be useful in assessing sacral screw fixation.

Aged↗
PubMed1992

Morphology of the dens. A quantitative study.

Morphometric studies of the dens of the second cervical vertebra were performed on a sample of one hundred twenty bones from the Hamann-Todd Collection. Data were collected on the longitudinal and transverse dimensions of the dens, as well as the size of the dens relative to the centrum of C2. Relationships of dens dimensions to body size and sexual dimorphism were evaluated. In both longitudinal and transverse mean dimensions, the dens in males was slightly, but significantly larger (5-10%) than in females. The relative distributions of dens dimensions were consistently skewed toward the higher values in males and the lower values in females. Body height or weight were not significantly correlated with dens dimensions, and were therefore poor predictors of the size of the dens. Implications for screw fixation of fractures of the dens are discussed.

Adult↗
PubMed1992

Quantitative internal dens morphology.

Recent work has demonstrated the highly variable and unpredictable external dimensions of the dens (odontoid process). No data have been available regarding internal dimensions. Quantitative computed tomography analysis of 120 axis vertebrae allowed nondestructive measurement of external and internal dens dimensions. The external computed tomography measurements correlated well with caliper-derived data. Minimum internal dens dimensions and cortical thicknesses in the sagittal and transverse planes are reported. Some axis vertebrae may not be amenable to internal fixation of type II dens fractures. Preoperative planning should include quantitative computed tomography analysis of the dens.

Adult↗
PubMed1992

Experimental stretch neuropathy. Changes in nerve conduction under tension.

We developed an animal model of stretch injury to nerve in order to study in vivo conduction changes as a function of nerve strain. In 24 rabbits, the tibial nerve was exposed and stretched by 0%, 6% or 12% of its length. The strain was maintained for one hour. Nerve conduction was monitored during the period of stretch and for a one-hour recovery period. At 6% strain, the amplitude of the action potential had decreased by 70% at one hour and returned to normal during the recovery period. At 12% strain, conduction was completely blocked by one hour, and showed minimal recovery. These findings have clinical implications in nerve repair, limb trauma, and limb lengthening.

Action Potentials↗
PubMed1992

Can burst fractures be predicted from plain radiographs?

Plain radiographs of 67 acute spinal compression fractures in 49 patients were analysed by subjective and objective criteria, using CT scans as the diagnostic standard for the diagnosis of burst fracture. Discriminant analysis correctly predicted the type of fracture in 88% of cases. Burst fractures, however, were almost as frequently misdiagnosed as being wedge compression fractures using this technique, compared with the reading of 25 films from patients without previous information. A quarter of the injuries would have been misdiagnosed had reliance been placed solely on the plain radiographs. CT scans of all patients with acute spinal compression fractures should be considered to decrease this potentially serious diagnostic error.

Diagnosis, Differential↗
PubMed1992

Strain, stress and stretch of peripheral nerve. Rabbit experiments in vitro and in vivo.

Mechanical stretching is known to cause morphologic and functional changes in peripheral nerve. The points at which these changes occur, however, are not clearly defined and reported data are conflicting. The studies presented in this paper provide a basic understanding of the biomechanical properties, stretch-injury patterns, and changes of conduction properties of peripheral nerves due to stretching. Our studies showed that peripheral nerves exhibited non-linear stress-strain characteristics when placed under tension. Initially, under tension, the nerve had a low modulus that increased gradually with increasing strain until reaching a maximal value. When the nerve failed under tension, the perineurium inside the nerve ruptured, but the exterior of the nerve remained intact. Our results also show that a peripheral nerve in situ was under significant strain, but minimal in situ stress (less than 0.05 MPa). The in situ strain might vary with limb position, but did not appear to exceed the limit beyond which substantial tension or stress would be developed in the nerve. The time-dependent viscoelastic behavior of peripheral nerves were also characterized. The maintenance of small in situ stresses suggests that sustained increases in tension could be adversely affecting the electrophysiologic properties of the nerve. Indeed, marked alteration of conduction properties resulted from even a small stretch of 6 percent beyond the in situ length of the nerve, or stress less than 10 percent of the ultimate strength of the nerve.

Animals↗
PubMed1992

Complications of anterior intervertebral grafting.

Reconstruction of the spine after anterior decompression is essential to restore stability and function. A variety of materials and methods are available to reconstitute the vertebral column. Numerous complications of anterior grafting have been identified, and include failure of the graft, graft extrusion, nonunion, and infection. The clinical severity of these complications vary. The use of spinal instrumentation has helped to address some of these problems. Although certain problems are the result of faulty decision making or technical error, others are related to the severity of the patient's disease and the limitations of grafting materials. Some complications can be avoided while others can be anticipated and perhaps corrected early.

Bone Transplantation↗
PubMed1992

Disk herniations associated with compression instrumentation of lumbar flexion-distraction injuries.

Flexion-distraction injuries are often treated by open reduction and fusion using compression instrumentation. Three cases that were complicated by disk herniation at the injured level, with an acquired neurologic deficit, are reported. Middle-column failure through the annulus fibrosis (Gertzbein and Court-Brown Type A) appeared to be a common feature. This may be a permissive condition for this complication as compression is applied across the torn annulus. Preoperative magnetic resonance imaging and postreduction myelography may identify such herniations. Acquired neurologic deficits after reduction and instrumentation demand emergent evaluation and treatment.

Adolescent↗
PubMed1992

Postoperative posterior spinal wound infections.

The incidence of postoperative spinal infections increases with the complexity of the procedure. Diskectomy is associated with less than a 1% risk of infection; spinal fusion without instrumentation is associated with a 1%-5% risk; and fusion with instrumentation may be associated with a risk of 6% or more. Twenty-two postoperative posterior spinal infections that occurred during a three-year period were reviewed for this report. Staphylococcus aureus was the most frequent organism cultured (more than 50% of the cases). Other recurring organisms were Staphylococcus epidermis, Peptococcus, Enterobacter cloacae, and Bacteroides. Many patients had multiple organisms. Risk factors appeared to include advanced age, prolonged hospital bed rest, obesity, diabetes, immunosuppression, and infection at remote sites. Operative factors included prolonged surgery (greater than five hours), high volume of personnel moving through the operating room, and instrumentation. Postoperative contamination may occur and may be related to prolonged postoperative bed rest, skin maceration (thoracolumbosacral orthoses), and drainage tubes exiting distally from lumbar wounds (toward the rectum). Effective treatment includes early diagnosis, surgical debridement and irrigation, and parenteral antibiotics. Superficial infections were treated successfully with wound closure over outflow tubes, and deep infections with inflow-outflow systems. Maintaining the instrumentation in place was possible in most cases. Parenteral antibiotics were maintained for six weeks in every case.

Anti-Bacterial Agents↗
PubMed1992

Surgical management of cervical radiculopathy. Indication, techniques, and results.

Cervical radiculopathy can be surgically approached either posteriorly or anteriorly and the anterior approach has been described with or without fusion. The choice of approach and technique must be based upon anatomic, pathophysiologic, and biomechanical principles in addition to the familiarity of the surgeon with the procedures. The authors discuss the use of the posterior approach for lateral soft-disk disease because it minimizes disruption of soft and bony tissues and does not markedly disrupt the biomechanics of the cervical spine. The anterior approach is preferred for radiculopathy involving osteophytic hard-disk disease, and when properly and carefully performed, the addition of an interbody fusion holds significant advantages over diskectomy without fusion.

Cervical Vertebrae↗
PubMed1991

A new technique for the in vitro measurement of nucleus pulposus swelling pressure.

Swelling of the intervertebral disc nucleus pulposus may be a contributing factor in lower back pain syndromes. We have designed and tested a new osmometer for in vitro determination of nucleus pulposus swelling pressure. The functional principle of the osmometer involves compressing a sample of nucleus pulposus with nitrogen gas until saline pressure gradients across a 0.45-micron Millipore filter are eliminated. Swelling pressures of both pooled dog and pooled pig lumbar disc nucleus pulposus were measured on the new osmometer and were compared with swelling pressure determined using the equilibrium dialysis technique. The osmometer measured swelling pressures comparable to those obtained by the dialysis technique. This osmometer provides a rapid, direct, and accurate measurement of swelling pressure of the nucleus pulposus.

Animals↗
PubMed1991

Stress relaxation of a peripheral nerve.

This study determines the change in tension after an acute nerve lengthening, as would occur in peripheral nerve repair. Stress relaxation, a viscoelastic property, was studied with the use of 24 rabbit tibial nerves. The nerves were divided into three groups and were stretched 6%, 9%, or 12% beyond their original resting length. The mean 1-hour stress relaxations for the three groups were 48%, 34%, and 34%, respectively. Nerve stress relaxation was significantly greater at 6% strain than at 9% or 12% strain. These biomechanical findings have important clinical implications for nerve-stretch injury and for nerve repair.

Animals↗
PubMed1991

Effects of acute, graded compression on spinal nerve root function and structure. An experimental study of the pig cauda equina.

A well-controlled experimental model for analysis of compression-induced functional changes of the porcine cauda equina is presented. The model allows for electrophysiologic investigation of a variety of neurophysiologic changes induced by nerve root deformation. At an acute pressure threshold of 50-75 mm Hg, changes in both afferent and efferent conduction are induced. With higher compression pressure, a differential recovery in afferent and efferent conduction is seen.

Action Potentials↗
PubMed1991

Anatomic comparison of the Roy-Camille and Magerl techniques for screw placement in the lower cervical spine.

The Roy-Camille and Magerl techniques for screw placement in the lower cervical spine were compared under simulated operating room conditions. Three surgeons with varying years of spine surgery experience participated. The anatomic morbidity risks of each screw insertion technique were evaluated by anatomic dissection and radiographic examination. The spinal cord and vertebral arteries were not threatened by either method. Analysis of the pooled data revealed that the Roy-Camille technique had less risk of nerve root injury, nerve roots placed "at risk" for injury, and errors in "zone" of placement. The Magerl technique had less risk of facet joint violation. A learning curve was observed. Once the surgeons gained experience with the two techniques, there were no longer any statistically significant differences among them. The number of years of spine surgery practice did not influence the morbidity risk of either technique. The surgeons' ability to aim the screws was identical in the axial plane, but consistently less accurate in the sagittal plane for the Magerl screws because of the normal prominence of the cervicothoracic junction. Thorough familiarity with the regional anatomy and practice in the anatomy laboratory are recommended before performing these techniques in patients.

Bone Screws↗