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Biomedical subjects

S R Merchant

Publications and source records attributed to S R Merchant.

8 recordsLinked to original sources
PubMed1995

Ototoxicity assessment of a gentamicin sulfate otic preparation in dogs.

Vestibulotoxic and ototoxic effects often are seen after long-term, high-dose systemic treatment with gentamicin, but toxic effects after topical use have not been reported in animals, to the authors' knowledge. Vestibular and auditory effects of twice daily otic gentamicin treatment for 21 days were evaluated in 10 dogs with intact tympanic membranes and in the same 10 dogs after experimental bilateral myringotomy. Each dog served as its own control; 7 drops of gentamicin sulfate (3 mg/ml in a buffered aqueous vehicle) were placed in 1 ear, and 7 drops of vehicle were placed in the opposite ear. Treatment and control ears were reversed after myringotomy. Vestibular function was evaluated daily by neurologic examination and behavioral assessment. Auditory function was evaluated twice weekly by determination of brain stem auditory evoked potentials. Gentamicin sulfate placed in the ear of clinically normal dogs with intact or ruptured tympanic membranes, in the quantities used in this study, did not induce detectable alteration of cochlear or vestibular function. Serum gentamicin concentration after 21 days of treatment was detectable in only 2 dogs and was an order of magnitude below documented toxic concentrations.

Analysis of Variance↗
PubMed1994

Ivermectin toxicosis in a kitten.

A 4-month-old female kitten developed generalized ataxia, mild tremors, weakness, incoordination, and miosis after receiving an injection of ivermectin (0.3 mg/kg of body weight, SC) for treatment of ear mite infestation. The kitten became comatose within 12 hours, and despite supportive treatment, died 7 days after administration of ivermectin. Caution should be exercised when this drug is administered parenterally to kittens.

Age Factors↗
PubMed1994

Ototoxicity.

This article describes the pathophysiology of ototoxic agents and contains a list of potential ototoxic agents including a list of animal species in which the toxicity has been documented or research studies performed.

Animals↗
PubMed1991

Babesiosis of companion animals and man.

Babesiosis is caused by numerous organisms and is seen in a wide range of vertebrate hosts. The spectrum of disease is broad and ranges from asymptomatic carrier states to fulminant disease that results in rapid death. The importance of babesiosis in companion animals is well-recognized in parts of the world where virulent strains exist and where the diagnosis and treatment of both typical and atypical presentations is part of the everyday course of events for the small animal clinician. In parts of the world such as the United States where less virulent strains are found, diagnosis is more difficult. Diagnosis requires an astute eye examining the blood smear and a keen mind willing to "consider the zebras without forgetting the horses." Babesiosis is not uncommon in the United States; it is merely uncommonly diagnosed. The small animal clinician needs to be aware of the disease and its myriad possible presentations. A clearer understanding of the disease will lead to a truer picture of its importance not only in the United States but also worldwide.

Animals↗
PubMed1991

Dermatologic aspects of tick bites and tick-transmitted diseases.

Dermatologic manifestations of tick bites and tickborne disease are not commonly encountered. However, recognition of the signs and histopathologic conditions of tick bites can be important to the diagnosis and management of small animal diseases. Understanding the local nodular inflammatory reaction to a tick bite can allay the owner's fear that a newly recognized nodule may be a malignant growth. Additionally, recognition of tick bites and pathognomonic dermatologic changes may provide important evidence in making a diagnosis of tick-transmitted diseases.

Animals↗