Biomedical subjects

S R Orell

Publications and source records attributed to S R Orell.

36 records · Page 2Linked to original sources

PubMed1982

The typing of non-Hodgkins lymphomas using fine needle aspiration cytology.

Fine needle aspiration cytology smears and histology sections from 53 cases of non-Hodgkin's lymphoma (NHL) were reviewed blindly and independently to determine the accuracy of cytological subtyping of NHL. It was decided to use the Kiel classification as it is based on cytological criteria. There was full agreement between the cytological and the histological classification in 44 of 53 cases. The cases were correctly assigned to a good or bad prognostic group in 48 of 49 instances in which a cytological diagnosis was made. It is felt that fine needle aspiration biopsy for cytology is sufficiently accurate to be of practical value in the following circumstances. 1. As a sole morphological diagnosis so as to avoid major surgery in cases of advanced disease without superficial node involvement. 2. To assess the extent of node involvement following histological diagnosis without further surgery. 3. In the selection of a representative node for surgical biopsy. 4. In the investigation of recurrent disease.

Adult↗

PubMed1981

Cutaneous malignant melanoma in South Australia: the main features.

New cases of primary cutaneous melanoma occurring in South Australia in a period of 12 months were studied. The main clinical and pathological features are reported. The incidence is high, but is much less than that reported in Queensland in 1977. Some differences from the Queensland study, concerning the age, sex and site distribution, have been noted, but generally these features are quite comparable. All major pathological types of malignant melanoma occur in South Australia, with a marked preponderance of the superficial spreading type. On the basis of level of invasion and thickness, more than half of the tumours have a good prognosis. The most common reason for excision of melanomas was the observation of a change in the lesion, but some were excised after incidental recognition by a medical practitioner during medical examination for other reasons.

Adolescent↗

PubMed1980

International pathologists congruence survey on quantitation of malignant melanoma.

A congruence survey of pathologists in Brisbane, Adelaide, Oslo and Paris on classifying and grading histological features such as dermal invasion, cross-sectional profile, mitotic activity and lymphocytic infiltrate was done on 147 cutaneous melanomas. The overall agreement was about 70%, about one pathologist in three or four disagreeing on each feature. Taking into acount also the considerable number of slides in which agreement was less, the results are considered unsatisfactory. Agreement was highest in cross-sectional profile and least in level of invasion. It is evident that the gradings are subjective and indicate the need for detailed histological description in making the criteria and the necessity of collaboration between pathologists to study slides and clarify problems. Experience is important and the slides must be of high technical excellence. Comparisons of results between different pathologists on the histological quantitations of malignant melanoma should take note of the degree of congruence achievable.

Humans↗

PubMed1979

Renal pelvic carcinoma in the Hunter Valley.

In the Hunter Valley, New South Wales, the incidence of renal pelvic carcinoma was found to be very high, and there appeared to be a causal relationship with analgesic abuse. The crude incidence rate was calculated at 1.6/100000 population per year. In half of the cases of renal pelvic carcinoma, there was evidence of analgesic abuse and/or analgesic nephropathy with papillary necrosis; in this group the male/female ratio was 1/2.6, and there was a tendency for the cancers to occur at a younger age. Tumours associated with analgesic nephropathy were more often poorly differentiated and in a more advanced stage at the time of diagnosis than those not associated with analgesic nephropathy. Multiple tumours were equally common in both groups, but coexistent flat carcinoma in situ tended to be more common in cases associated with analgesic nephropathy.

Adult↗

PubMed1978

Non-toxic goitre: diagnostic role of aspiration cytology, antibodies and serum thyrotrophin.

Fifty cases of bilateral non-toxic goitre, largely unselected, have been studied using fine needle aspiration cytology (without local anaesthesia); four techniques of thyroid antibody tests; serum thyroid biochemistry (including radioimmunoassay of TSH) and clinical evaluation. Autoimmune thyroiditis was found cytologically in 64%; simple colloid goitre in 24%; subacute thyroiditis of de Quervain in 10%. Aspiration cytology was the most sensitive means of detecting autoimmune thyroiditis and subacute thyroiditis. Two antibodies directed against the intra-cellular cytoplasmic antigen--the complement fixation test and an immunofluorescent antibody were of lesser value in detecting autoimmune thyroiditis (80% positivity) though equal to each other. Serum TSH was of some value--being elevated in 63% of cases of autoimmune thyroiditis and in no cases of simple colloid goitre. Two major cytological subtypes of autoimmune thyroiditis have been described--with significant differences in duration of goitre, mode of presentation, frequency of hypothyroidism, and response to thyroxine therapy. The high frequency of autoimmune thyroiditis in this series suggests that endemic goitre is unlikely in Western Australia.

Adolescent↗

PubMed1976

Aspiration cytology in Perth: experience of 673 cases.

The experience gained from the investigation of 673 patients by aspiration cytology is reviewed. The diagnostic accuracy of the technique is not satisfactorily demonstrated in this series owing to incomplete follow-up information. However, the almost unlimited application of aspiration cytology as a preliminary diagnostic test in focal lesions of most organs and tissues is emphasized. The chief merit of the technique is it simplicity which shoudl put it into the very front line of diagnostic procedures in suspected neoplastic disease.

Biopsy, Needle↗

PubMed1974