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Biomedical subjects

S R Richards

Publications and source records attributed to S R Richards.

7 recordsLinked to original sources

Signal preprocessing system for the small intestinal electromyogram.

The intestinal EMG obtained from chronically implanted electrodes in canine preparations provides for the evaluation of intestinal motor activity and its control. The basic electrical rhythm (BER) and spike components on the EMG signal provide evidence of control activity and a measure of contraction intensity, respectively. A hardware system is presented in which these two components are separated by filters and the contraction spikes counted in fixed epochs to yield a contraction spike per unit time record against time. The signal is also available in parallel binary form at the end of each epoch, together with a data-ready signal for direct acquisition by computer. Tests of system performance and operating protocols are given. The preprocessor is used as a fast front end to a digital signal processing system specifically built for intestinal EMG analyses.

Animals

The volumes of rat and human lung cells as measured by an image analyser.

Previous studies of the morphometry of lung cells have required long and tedious measurements involving serial sectioning and the reconstruction of models. However the advent of computer-based image analysers offers a more straightforward, although less direct, method of making such measurements. In the present study a Magiscan has been used to investigate the shapes and sizes of the nuclei from the lung cells of three mammalian species. Associated cellular volumes have also been derived. Based on the measurements of about two hundred cells the mean volumes of rat, beagle and human lung cell nuclei were estimated to be 67 microns 3, 41 microns 3 and 78 microns 3 respectively. Cell volumes were estimated to be about 500 microns 3. It was also confirmed that a sphere is a very poor approximation for the shape of a nucleus, spheroids representing the observations much more closely.

Animals

Intravenous ritodrine as a possibly provocative predictive test in gestational diabetes. A case report.

A 24-year-old, nonobese, gestational diabetic woman developed diabetic ketoacidosis while receiving intravenous ritodrine therapy to suppress premature labor. This case emphasizes the necessity for close observation of any gestational diabetic during intravenous ritodrine tocolysis and suggests the possibility of predicting diabetes in pregnant patients exhibiting marked glucose intolerance during therapy.

Adult

Serum carotene levels in female long-distance runners.

Hypercarotenemia has been associated with anorexia nervosa and hypothalamic amenorrhea. With the emergence of a spectrum of menstrual dysfunction, including anovulation in women runners, the hypothesis of hypothalamic amenorrhea in these patients has been formulated. Other authors have proposed exercise-associated amenorrhea to be distinct from hypothalamic amenorrhea based on endocrine profiles. Using carotene as an index test of hypothalamic amenorrhea, we have studied female long-distance runners (greater than 25 miles/week) and have found no difference in the carotene levels between ovulatory (midfollicular) and anovulatory runners. These data support other evidence that exercise-associated amenorrhea is distinct from hypothalamic amenorrhea.

Adult

Intrapartum pulmonary embolus. A case report.

Intrapartum pulmonary embolus is rare. In a case we encountered, both the mother and infant survived. The peripartum period is a relative contraindication to the use of thrombolytic therapy due to the risk of postpartum hemorrhage. The indications for embolectomy and vena caval interruption are the same as the ones generally accepted.

Adult