Biomedical subjects
Publications and source records attributed to S R Shorb.
Three patients (a 44-year-old woman, a 65-year-old man, and a 39-year-old woman) who had had diabetes mellitus for an average of 17 years had good vision and mild to moderate background diabetic retinopathy. These patients developed severe iron deficiency anemia from varying causes and their conditions rapidly progressed to a severe proliferative phase that necessitated panretinal photocoagulation and pars plana vitrectomy in two cases.
Disk neovascularization associated with chronic uvetitis occurred in five patients. The uveitis was most frequently diagnosed as chronic cyclitis, with a marked inflammatory cell response in the vitreous body. Using direct and indirect ophthalmoscopy, slit-lamp biomicroscopy with the Goldmann contact lens, perimetry, and fluorescein angiography and angioscopy, we found no areas of vascular occlusion or nonperfusion. Inflammation probably produced chemical mediators capable of traveling to the optic disk and inducing neovascular proliferation, in the absence of retinal vascular occlusion.
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Optociliary veins occur in three clinical settings: in chronic central retinal vein obstruction, with retro-orbital tumors, and as congenital anomalies. In the last setting, associated anomalies of the disc and retinal vessels may be present, which makes differentiation from the first two difficult. Fluorescein angiography may be of value in making this differentiation for, in some if not all congenital OC veins, the direction of flow is from the choroid into the central retinal vein. Two cases are presented in which a congenital optociliary vein was present in association with a fundus picture mimicking a central retinal vein obstruction or papilledema. In both cases, fluorescein angiography demonstrated that the vessel was a congenital anomaly, draining from the choroid into the retina.