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Biomedical subjects

S Röhling

Publications and source records attributed to S Röhling.

At least 37 records · Page 2Linked to original sources
PubMed1979

Comparison of the distribution of diagnostic and thyroablative I-131 in the evaluation of differentiated thyroid cancers.

In 206 patients with differentiated thyroid cancer, the distribution of iodine-131 were compared after diagnostic (200-500 microCi) and thyroblative (approximately 100 mCi) doses. In the diagnostic scans, only normal thyroid tissue could be seen, whereas in one-fourth of the patients the therapeutic scans showed tumor tissue as well, usually in lymphnode metastases. In 16% of patients, the therapeutic scan was the only way to demonstrate the presence of tumor tissue, since no further uptake was achievable. In patients in whom all tumor was believed to have been removed by surgery alone, a "preventive" I-131 ablation was used, and in 16 of these 97 patients tumor was revealed in the therapeutic scan. In ten more, tumor was found in subsequent followup scans, its functioning having been induced by destruction of postsurgical remnants of normal thyroid. Some possible explanations for the differences in scans are proposed, and the importance of therapeutic scans for correct staging of thyroid cancer is stressed.

Adult↗
PubMed1979

Radioiodide treatment of pulmonary metastases of differentiated thyroid cancer. Results and prognostic factors.

Pulmonary metastases were found in 123 out of 840 patients with thyroid cancer between 1955-1977, 87 patients with pulmonary metastases of differentiated cancer were studied in detail, including an evaluation of prognostically important factors. In 66 of them, the induction of 131I uptake in metastases was attempted, in half of them successfully. Uptake was achieved more frequently in younger subjects, in papillary cancers and in patients with fine pulmonary metastases on chest films. Survival (not corrected for age) was evaluated 10 and 15 years following the diagnosis of thyroid cancer and was found to be 29,1% and 12,2%, respectively. Significantly higher survival rates were seen in younger patients, in patients with the fine type of pulmonary metastases, in the absence of bone metastases and, particularly, in patients with induced 131I uptake in metastases. Papillary cancers were found to have higher survival rates in males and in young subjects only, in the whole group the survival rates were independent of either microscopic type or sex. It is believed that biologic behaviour of distant (pulmonary) metastases may be influenced by radiodide therapy.

Adult↗
PubMed1979

Pulmonary metastases of thyroid carcinoma.

In a group of 840 patients with thyroid carcinoma the authors found pulmonary metastases in 123 patients, i. e. in 14.6%. In 78 pulmonary metastases were the only remote ones, in the remainder they were combined also with other remote metastates, almost always bone metastases. Cases of "pure" pulmonary metastases were found in the whole group without a proved relationship to age and histology, with a slight prdominance of men, while in patients with a combination of pulmonary and bone metastases follicular carcinoma predominates and it is found mainly in patients of more advanced age. The biological behaviour of these two groups differs completely, and this should be taken into account in the international TNM classification. When investigating the biological properties of thyroid carcinoma, we evaluated in detail in a recent publication (15) bone metastases. As all remote metastases of thyroid carcinoma are included according to the classification of WHO under the common sign M1 (9), we wanted to compare some factors in the incidence of pulmonary and bone metastases.

Adenocarcinoma↗
PubMed1979

Developmental changes in uptake of 3H-progesterone by rat ovaries.

3H-progesterone uptakes by the ovaries and skeletal muscles were compared in newborn female Wistar rats and in other females aged five, ten, 15, 20, 25, and 50 days, two hours after one single intraperitoneal injection of 50 muCi/100 g body weight. The ratio of the concentration of radioactivity between the ovaries and the skeletal muscle increased significantly at the age of 15 days. The increase in ovary/skeletal muscle raio (characterised by a logistic curve) suggests the first appearance of specific binding capacity for progesterone, coinciding with an increase in plasma progesterone level and beginning of the distince atretic changes in compact and cavitated follicles simultaneously with the attainment of capability to ovulate following adequate exogenous gonadotropic stimulation. The early postnatal period of protective short-term treatment, using progesterone, against the early androgen or oestrogen syndrome of anovulatory sterility and/or noxious long-term treatment, using progesterone, inducing a delayed anovulatory syndrome precedes the beginning of preferential accumulation of 3H-progesterone in the ovary.

Animals↗
PubMed1979

Functional activity of a thyroid nodule under the influence of stable iodide administration in a hyperthyroid patient.

In a thyrotoxic patient with nodular goiter treated with stable iodide and Carbimazole, a series of 131I scans was performed at different intervals for proposed 131I therapy. Originally, total uptake was suppressed and the node was evaluated as active. The same type of scan was seen repeatedly with uptake increasing for about 6 months following stable iodide withdrawal. Only 9 months later, the effect of 127I disappeared and uptake rose considerably with a reversal of the scan to the picture of a hypofunctioning node. The same distribution was found after therapeutic 131I administration. 6 months following treatment, without any thyrostatic drugs, the patient was euthyroid and on the scan most of tracer was found in the node. It is believed that this change is best explained by the different sensitivity of the nodule and the paranodular tissue to the effect of stable iodide. It is believed that the hyperthyroidism originated in the paranodular tissue highly sensitive on the 127I, while the nodule (presumably an adenoma) was less sensitive and showed uptake only when the paranodular tissue was depressed by 127I or, later, injured by the effect of therapeutic 131I.

Carbimazole↗
PubMed1979

The value of plasma TSH estimation and TRH stimulation test in the course of treatment of differentiated thyroid cancers.

Plasma TSH levels were measured on 114 occasions in 96 patients treated for differentiated thyroid cancer. Prior to thyroid surgery, plasma TSH levels were within the range of normal. Plasma TSH levels increased slightly following partial thyroid resection and definitely after total thyroid ablation. In patients where the removal of normal thyroid induced hormonogenesis in thyroid tumours, plasma TSH levels were dependent on the hormonal secretion of the tumour as shown by inverse relationship between TSH and both PBI and 131I uptake. The increase of radioiodide uptake following stimulation by exogenous bovine TSH was inversely related to the plasma thyrotropin levels. The suppressibility of enhanced thyrotropin levels was complete with individually adjusted doses of synthetic thyroid hormones. With the exception of patients on suppressive treatment, TRH administration induced increase in plasma TSH levels. The findings are discussed with regard to the role played by TSH in the induction of hormonogenesis in thyroid tumours. The practical values of TSH estimation and TRH stimulation seem to be low; the measurements of thyrotropin levels may be important for the estimation of the suppressive effect in the course of and following withdrawal of treatment with thyroid hormones.

Humans↗
PubMed1975

Changes in uptake of 3H-progesterone by female rat brain and pituitary from birth to sexual maturity.

3H-progesterone uptake by various parts of the brain, pituitary and skeletal muscle was compared in newborn, 5-, 10-, 15-, 20-, 25- and 50-day old female rats at 1 hr after a single intraperitoneal injection of 50 muCi/100g body weight. High uptake values in newborn animals and in those aged 5 days were found in all tissues investigated. A sharp decrease in accumulation was observed from birth and/or 5th day of life. The uptake by pituitary was persistantly higher than those by other tissues investigated. The ratio of the concentration of radioactivity between the tissues and the cerebellar cortex increased significantly only in the posterior hypothalamus of adult females (at the age of 50 days). In the pituitary the ratio tissue/cortex was already significantly higher in newborns. The high level of brain radioactivity in the youngest animals is probably a manifestation of high plasma concentrations of tritiated progesterone. The striking decrease in uptake of radioactivity by the brain and pituitary during the first two weeks of life most likely reflects the decrease in level of plasma radioactivity, as shown indirectly by the concomitant decrease in labelled progesterone uptake by the skeletal muscle. The increase in tissue/cortex ratio in the posterior hypothalamus with attainment of sexual maturity suggests the first appearance of specific binding capacity for progesterone which is assumed to be present in the pituitary already from birth.

Age Factors↗
PubMed1975

Serum thyroxine estimation: clinical evaluation of a modified semiautomated method and its ability for differential diagnosis of thyroid diseases.

A modified semiautomated microchemical method for determining serum thyroxine has been described. It consists of the isolation of T4 on a column of cation exchange resin Dowex 50 W X 2 and of a fully automated determination of iodine in the ammoniacal eluate from the column after an acidic mineralization. The diagnostic value of the method has been evaluated on a small group of patients examined for suspected thyroid gland dysfunction, in comparison with a parallel determination of T4 by a CPBA method (Tetrasorb test kit). From the results it follows that the microchemical method gives the results something inferior in comparison with the CPBA technique. The differences of means between the basic diagnostic groups of patients (euthyroids, hypothyroids, and hyperthyroids) in both methods were statistically significant. The extent to which these tests can discriminate was investigated at a 5% discrimination threshold. The discriminatory ability of both methods between hyperthyroidism and euthyroidism is nearly the same. The CPBA method discriminates euthyroids from the hypothyroids better, the results of both tests, however, do not differ too much. It seems to be confirmed that irrespective of the method used, the determination of serum T4 itself can detect neither hyperthyroidism nor hypothyroidism reliably. The possible causes are discussed in this paper.

Autoanalysis↗