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Biomedical subjects

S Rae

Publications and source records attributed to S Rae.

13 recordsLinked to original sources

Cuffed tube tracheostomy in the dog.

A surgical technique of performing tracheostomy in dogs requiring prolonged intubation with either cuffed or uncuffed tubes is described. Cannulae used in humans are anatomically unsuitable for the dog. The cannula and cuff described in this paper did not predispose to severe mechanical trauma to the trachea and we attempted to minimize factors that may predispose to tracheal damage during the period of intubation and the subsequent development of late tracheal injuring after extubation. A simple method of humidification in these healthy dogs proved adequate; neither tenacious tracheobronchial secretion nor the retention of secretions were seen.

Animals

Haemophilus influenzae type b disease. Incidence in a day-care center.

Haemophilus influenzae type b (HIB) disease was observed during a 14-month period in seven of 48 infants attending a day-care center. Surveillance studies showed that 28 (58%) infants had positive nasopharyngeal cultures for HIB; four infants were colonized with HIB for nine to 12 months. Ampicillin trihydrate prophylaxis failed to reduce the HIB carrier rate. Haemophilus influenzae type b polysaccharide vaccine was administered to 34 of the children. Sera obtained prior to immunization showed detectable antibody in all infants. Only nine (26%) infants had twofold or greater rises in serum HIB antibody titers after vaccination. Antibody response was independent of age, preimmunization antibody concentration, and HIB carrier status. In one infant, HIB meningitis developed four months after she received polysaccharide vaccine. This outbreak emphasizes that HIB is highly contagious in closed populations of young, susceptible infants.

Antibodies, Bacterial

Salmonella typhimurium arthritis in rheumatoid disease.

Septic arthritis is a well recognized complication of rheumatoid arthritis (British Medical Journal, 1976; Mitchell et al., 1976), particularly after joint replacement (Freeman, 1976). We report here infection with an unusual organism--Salmonella typhimurium.

Aged

A manometric study of the upper oesophagus in the dog following cuffed-tube tracheostomy.

Intraluminal oesophageal pressures were measured in dogs after tracheostomy and intubation with either uncuffed or cuffed tracheostomy tubes. Possible explanations for disordered swallowing following tracheostomy were found in those animals intubated with cuffed tracheostomy tubes: (a) Increased intraluminal pressures were measured in the oesophagus at the level of the cuffs. (b) Significantly increased pressures were found also 5 and 10 cm below the pharyngo-oesophageal junction. (c) The upper oesophageal sphincter relaxed incompletely.

Animals

Tracheal size following tracheostomy with cuffed tracheostomy tubes: an experimental study.

In view of the severe damage caused by unyielding, low residual volume cuffs, various modifications to the cuff of an intratracheal tube have been introduced. The merits of two low-pressure cuffs were assessed in an experimental study in dogs; both cuffs produced little visible damage to the tracheal wall in dogs intubated continuously over a two-week period. A modified technique of producing tantalum tracheobronchograms without distrubing the mucous blanket or traumatizing the tracheal wall is described. These tantalum radiological studies demonstrated a progressive temporary increase in size of the trachea at cuff level over the period of intubation with these cuffs. The implications of such a progressive weakness occurring in the tracheal muscle are discussed.

Animals