Biomedical subjects
Publications and source records attributed to S Raffai.
Polypoid melanoma is a less known aggressive variant of nodular melanoma. It is characterised by earlier manifestation, exophytic growing, more frequent secundary alteration and whorse prognosis. On the basis of clinical and histological data of 14 patients, authors present characteristics of polypoid melanoma its differential-diagnosis and draw attention to the stressed importance of clinical diagnosis and treatment.
22 female patients suffering from idiopathic hirsutism were treated according to Hammerstein's reversed sequential scheme over 12 months. During each treatment cycle of 21 days, the daily medication consisted of 1 coated tablet containing 0.035 mg ethinyl estradiol and 2 mg cyproterone acetate (Diane-35); in addition, the patients received one i.m. injection of 300 mg cyproterone acetate (Androcur-Depot) on the first day of each cycle. This therapy resulted in improvement of the disease in 19 of our patients (86.4%). The transitory, mild side effects observed did not require interruption of the treatment. The reversed sequential scheme making use of the depot form of CPA can successfully be administered in patients with hirsutism.
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