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Biomedical subjects

S Rajkumar

Publications and source records attributed to S Rajkumar.

30 records · Page 2Linked to original sources
PubMed1980

Lichen sclerosus et atrophicus in an eleven year old girl. Report of a case.

An elevent year old girl who presented with constipation of two years' duration was found to have atrophy and depigmentation of the anogenital area. Results of a skin biopsy confirmed the diagnosis of lichen sclerosus et atrophicus, which is a rare disease in children. Treatment of the disease is non-specific, and it usually disappears in half of the patients around the time of menarche. Long-term follow-up of persistent anogenital lesions is necessary.

Anal Canal↗
PubMed1979

The emotional disturbance underlying alopecia areata, alopecia totalis and trichotillomania.

A psychological study on fifteen children with diverse etiologies of hair loss, viz., alopecia areata, alopecia totalis and trichotillomania was conducted in order to assess the degree of underlying psychodynamics in children with hair loss. The results confirm the relationship of the underlying emotional disturbance to the hair loss. Further, it appears that the more severe the psychopathology of the individual, the greater is the hair loss and/or the clinical manifestation of trichotillomania.

Affective Symptoms↗
PubMed1979

Shigella vulvovaginitis in childhood: a case report.

Vulvovaginitis due to Shigella sonnei is reported in a four-year-old child.Shigella sonnei as a rare primary pathogen causing vulvovaginitis, the prolonged nature of the clinical course, and the therapeutic implications of increasing resistance to ampicillin by the organism are discussed.

Child, Preschool↗
PubMedDate not supplied

Factors affecting relapse in schizophrenia.

96 first episode schizophrenic patients were included for a prospective follow-up study on factors affecting course and outcome of schizophrenia. Feighner's diagnostic criteria were used for inclusion and a yearly assessment was made using the Present State Examination and the Personal and Psychiatric History Schedule. At the end of 3 years, 64 patients had been followed up. Of these, 38 patients had one or more relapses. A comparison of the relapsing group with the non-relapsers revealed certain variables to be significantly associated with relapses. Some of these were regularity of follow-up, presence of affective symptoms and self-neglect and lack of social contacts. The importance of recognising these factors in order to prevent relapses in schizophrenia is discussed.

Adult↗
PubMedDate not supplied

Trimethoprim in pediatric urinary tract infection.

The efficacy of trimethoprim (TMP) as a single therapeutic agent in the treatment of urinary tract infection (UTI) in children was studied in 112 children prospectively comparing TMP against trimethoprim-sulfamethoxazole (TMP/Sulfa), sulfamethoxazole and ampicillin. Children with repeated colony counts of greater than 100,000 CFU/ml of the same organism grown in 2-3 consecutive clean catch specimens were successively assigned to each treatment group for 10 days' therapy. TMP achieved a cure rate of 100% compared to TMP/Sulfa 100% (p greater than 0.05), sulfamethoxazole 93% (p less than 0.05) and ampicillin 63% (p less than 0.01). TMP and TMP/Sulfa groups had no failures while sulfamethoxazole and ampicillin groups had 7% (p less than 0.05) and 37% (p less than 0.01), respectively. Relapses occurred in 4% of the TMP group whereas TMP/Sulfa had 7% (p greater than 0.05); sulfamethoxazole and ampicillin groups had none. TMP group had 7% recurrence compared to 6% TMP/Sulfa, 4% sulfamethoxazole and 7% ampicillin (p greater than 0.05). Gastrointestinal side effects and skin rashes were not encountered in the TMP group; depression of WBC was the lowest in this group. As a single therapeutic agent, TMP appears to be safe and efficacious for treatment of acute UTI in children.

Ampicillin↗
PubMedDate not supplied

Progressive renal damage due to lead intoxication in early life.

We have evaluated the effect of an increased body lead burden in young (3 weeks old) and adult (9 weeks old) Sprague-Dawley rats. Following intraperitoneal administration of lead on two occasions, both renal blood flow and glomerular filtration rates were diminished in the young rats, but not in the adult rats. Our study lends credence to the hypothesis that age at the time of exposure is critical to the development of progressive renal damage.

Age Factors↗