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Biomedical subjects

S Rashiq

Publications and source records attributed to S Rashiq.

10 recordsLinked to original sources
PubMed1999

Proximal myofascial dysfunction in complex regional pain syndrome: a retrospective prevalence study.

OBJECTIVE: To assess the prevalence of clinically evident myofascial dysfunction (MD) and its relationship to motor neglect (MN) in Complex Regional Pain Syndrome (CRPS). DESIGN: Retrospective chart review. PATIENTS: Forty-one consecutively evaluated CRPS patients. OUTCOME MEASURES: (a) Prevalence of trigger points in the proximal musculature of the CRPS limb. (b) Prevalence of MN in a subset (n = 34). RESULTS: MD was detected in 61 % of CRPS patients. It was more prevalent in the upper limb (70%) than in the lower limb (47%). MN was more common in those who also had MD. CONCLUSION: MD is common in CRPS patients, especially in the upper limb and in those patients with MN. Prospective trials are needed to confirm these intriguing findings, which may have important implications regarding CRPS pathophysiology and treatment.

Adult↗
PubMed1994

Recovery characteristics following induction of anaesthesia with a combination of thiopentone and propofol.

The purpose of this study was to determine the rate and quality of recovery when general anaesthesia was induced with a mixture of thiopentone and propofol, compared with thiopentone or propofol alone. Sixty ASA class I and II women scheduled for out-patient laparoscopic surgery underwent induction of anaesthesia with either (i) thiopentone, (ii) propofol, or (iii) a mixture of the two, in a randomized, double-blind fashion. Anaesthesia was then maintained using nitrous oxide, isoflurane and fentanyl. A psychometric test was administered before and after surgery, and the time taken to reach a series of recovery milestones was noted. Patients were discharged as soon as they were ambulant and had satisfactory control of pain and nausea with oral agents. They were telephoned at 24-48 hr later, and asked to rate their experience of a list of side effects on an ordinal scale. Patient groups were demographically comparable and underwent surgery of the same duration. Those receiving thiopentone were discharged after a mean time of 3 hr 25 +/- 58 min (SD). The corresponding figures for propofol and the thiopentone/propofol mixture were 2 hr 40 min (+/- 49) and 2 hr 48 min (+/- 68) respectively. The recovery time between thiopentone and the other two regimes was different (P < 0.05). All three groups experienced equally frequent and severe nausea, headache, tiredness and other side effects during the next 24 hr. It is concluded that induction with a mixture of thiopentone and propofol leads to a similar rate and quality of recovery to that of propofol above.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1993

Distinguishing acyclovir neurotoxicity from encephalomyelitis.

OBJECTIVES: To define the clinical characteristics of acyclovir neurotoxicity and to outline how to distinguish it from viral encephalitis. DESIGN: Case series of acyclovir neurotoxicity. SETTING: All cases reported in Index Medicus or in bibliographic reviews of acyclovir neurotoxicity plus two representative studies of Varicella zoster and Herpes simplex virus encephalitis. SUBJECTS: Thirty-five patients who developed neuropsychiatric symptoms during acyclovir therapy. INTERVENTIONS: Analysis of the patients' demographics, risk factors, acyclovir dosages and duration, clinical and laboratory findings and outcome. MAIN OUTCOME MEASURES: All clinical and laboratory findings that were statistically significantly different from viral encephalitis. RESULTS: The median age was 53.3 years. The most common predisposing factors were the use of other potentially neurotoxic medications (17 cases) and acute or chronic renal failure (15 cases). Acyclovir levels were frequently found above the therapeutic range. The characteristic manifestations were confusion (15 cases), hallucination or delirium (9 cases), agitation (8 cases) and lethargy (10 cases). Few patients had associated tremors (11 cases). Fever, headache, seizures and focal neurologic findings were distinctly rare. Cerebrospinal fluid and computed tomography were normal except in patients with other central nervous system disorders. Symptoms appeared within 2 days of therapy in the majority and resolved completely within several days of discontinuing acyclovir. CONCLUSIONS: Acyclovir neurotoxicity is a self-limiting, dose-dependent phenomenon which is more common in the elderly, in patients with renal failure or in association with other neurotoxic medications. It is distinguished from viral encephalitis by its sudden onset, absence of fever or headache, lack of focal neurologic findings and normal cerebrospinal fluid.

Acyclovir↗
PubMed1986

Role of drugs in fractures of the femoral neck.

To investigate the role of drugs in the rising incidence of fractures of the femoral neck in the elderly a case-control study inquiring about the use of prescribed drugs was carried out. The drug histories of 102 patients with femoral neck fractures were obtained from general practice records and compared with those of 204 controls matched for age and sex from the same practices. At the time of fracture 41 patients with fractures and 126 controls were receiving at least one prescription (relative risk of fracture of the femoral neck in patients taking drugs = 0.42, p = 0.0006). For all types of prescribed drugs except antibiotics the risk of fracture of the femoral neck was less in patients taking drugs than in those not doing so, and this was true at all times in the year before fracture. Six patients with fractures were receiving thiazide diuretics compared with 37 controls (relative risk 0.28, p = 0.004). These results indicate that, contrary to popular belief, drugs that sedate or that impair postural control are not important factors in fractures of the femoral neck. The results are consistent with the hypothesis that the hypocalciuria induced by thiazides protects against fracture, but the degree of protection is not significantly greater than that associated with other drugs.

Aged↗