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Biomedical subjects

S Rasslan

Publications and source records attributed to S Rasslan.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Esophagogastric acute injury caused by a chemical agent].

UNLABELLED: Treatment of chemical agent ingestion remain controversial. The incidence of these episodes has increased over the several last decades due to a variety reasons. PURPOSE: To analyze the occurrence, complications and results of the treatment of chemically induced esophagogastric injury. METHODS: Twenty-one adult patients with chemically induced esophagogastric injury were retrospectively studied. The patients were admitted up to 23 days after ingestion of a chemical agent to the Emergency Department of Santa Casa of Sao Paulo University Hospital from August, in a 12-year period. The mean age was 32.1 years. Eleven patients were of the female gender, which attempted suicide. Soda was the most ingested agent (76.2%), muriatic acid was present in three cases (14.3%) followed by one case of sulfur acid and another one of ammonia (4.8% each). RESULTS: Injuries of the Larynx and Pharynx were frequently associated with those of the esophagus, accounting for 18 cases (85.7%). Esophageal, gastric and duodenal injuries were assessed and classified according to endoscopic features. Five cases each of severe esophageal or gastric lesions were present. CONCLUSION: Treatment and outcome varied and suggested placement of esophageal tube to be harmful. Global mortality rate was 28.6% with the highest rate related to esophageal injuries of the third degree.

Adolescent↗
PubMedDate not supplied

Ostomy or intestinal anastomosis in cases of peritonitis.

Twenty-six patients showing peritonitis due to nontraumatic acute abdomen were submitted to ostomy. Mean age was 51 years (range 25-83), being 13 males and 13 females. Bowel obstruction (BO) was the most frequent cause of peritonitis (11 cases), followed by intestinal perforation (IP) (8 cases), acute mesenteric infarction (AMI) (5 cases), and acute abdomen of inflammatory/infectious origin (AAIO) (2 cases). Brook's ileostomy was performed on 65% of the patients. Jejunostomy was performed only in 4 patients, leading to a bad evolution. Overall mortality was 54%. Primary ostomy or anastomosis in cases of peritonitis constitute a highly controversial theme. Indications and problems involving the intestinal exteriorization in emergency surgery urgency are herein discussed.

Adult↗
PubMedDate not supplied

[Effects of food restriction on the protein and electrolyte composition in the liver and muscles of rats].

Protein and electrolyte disturbances in hepatic and muscle tissues are related to trauma, sepsis, or short term starvation or semistarvation. The consequences of a prolonged semistarvation are poorly understood. For five weeks, male adult rats were offered 50% of the diet until they had a weight loss of 40%, after which protein and electrolyte (Ca++, Mg++, Zn++, Na+, K+) changes in the liver and soleus and extensorum digitorum longus muscles were analyzed. There was a significant weight loss after 5 weeks of semistarvation. Hepatic protein and serum albumin were not changed, but the authors observed a significant muscle protein depletion. A fall in Zn++ levels in the blood was accompanied by a rise in muscle and liver concentrations. The rise in Ca++ and Mg++ concentration in blood and in the muscles might be related to the enhanced proteolysis. Results suggest that the early changes of protein and electrolyte metabolism at tissue level with semistarvation impair muscular and hepatic functions as they delay adequate response to trauma and infection.

Animals↗
PubMedDate not supplied

[Gastrin changes in the gastric antrum G-cells and in serum gastrin levels after 80% jejunoileal resection in rats].

A study was made of the changes in the cell population producing gastrin of the gastric antrum in rats submitted to resection of 80% of jejunum-ileum. Ninety days after surgery, the animals were killed after a 12 hour nightly fast and the gastric antrum was removed with the objective of specific histological preparations (PAP method) in order to count the G-cells and the blood was taken for serum doses of gastrin. An optical microscope was used to count the cells using a histometric integraded ocular of 42 points and the counting of 10 fields of each histological cut, and the radioimmunoassay method of double antibody was used for the seric dosing of gastrin. Histometry showed a significant drop in the G-cell population of the antrum of enterectomized animals when compared to the control group. Average percentage of G-cells found were 17.55% in the control group and 7.99% in the enterectomized ones. Blood dosing of hormone showed a significant increase of gastrin in the enterectomized animals when compared to controls. Average value of gastrin dosing the control group was 110 Pg/ml and 170 Pg/ml in enterectomized animals. Therefore, the present study permits to conclude that after resection of 80% of jejunum-ileum, there was a decrease in the G-cell population with gastrin in the gastric antrum even in the presence of increased serum gastrin.

Animals↗
PubMedDate not supplied

[Severe acute pancreatitis, laparotomies, and planned reoperation].

Of 111 cases of acute pancreatitis studied, 13 (11.7%) patients had severe pancreatitis with infection and were submitted to planned reoperation or to open peritoneal drainage. Twelve patients were male, ages ranging from 20 to 56. The etiology was biliary in 4 patients, traumatic in 1 patient, and alcoholic in 8 patients. Early treatment included clinical support at the intensive care unit and surgical intervention was performed after the first week based on clinical signs and on ultrasound and CT scan findings. A total of 42 surgeries was performed (mean of 3.23 operations per patient). Mortality rate was 46% due to systemic complications and to multiple organ failure.

Acute Disease↗
PubMedDate not supplied

[Use of transhepatic drainage in repair of the main bile duct].

The transhepatic intubation to treat and minimize recurrent stricture after hepaticojejunostomy is analysed. This method was used in seven patients. Three of them had a malignant biliary stricture and four had bile duct injury during cholecystectomy. In four occasions the reconstruction of right and left hepatic ducts were done separately. In two the anastomosis with the jejunum was performed with the left hepatic duct and ducts of medial and lateral segments of right hepatic lobe and in two hepaticojejunostomy was performed. The transhepatic tube was maintained for three to ten months. The patients with malignant disease died after ten days, 35 days and nine months. In the four patients with benign disease, two had an excellent response. One did not and in one the follow up is short to assess the final result. The advantages and disadvantages of transhepatic intubation are discussed.

Adult↗