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S Rocca Rossetti

Publications and source records attributed to S Rocca Rossetti.

28 records · Page 2Linked to original sources
PubMed1986

Single-shot vs conventional therapy with amikacin for treatment of uncomplicated urinary tract infections: a multicenter study.

Results are discussed of a national Italian survey carried out by 1,689 general practitioners supervised by 112 hospital specialists. The goal of the survey was to check the efficacy and tolerance of single-shot (single dose) treatment of uncomplicated urinary tract infections with amikacin. 22,216 patients were evaluated, over 23,521 treated, and positive results were obtained in 73.7% with single-shot amikacin, 25.6% with conventional therapy with amikacin 15 mg/kg/day X 7 days, resulting in a total effectiveness of 99.3%. Adverse effects (tinnitus, equilibrium disorders, azotemia and creatinine levels higher than standards) were reported in 0.96% of the patients (0.37% in single-shot, 2.63% in conventional treatment). These data indicate that a single dose (single-shot) administration of amikacin can be a rational and advantageous treatment of uncomplicated urinary tract infections.

Adolescent↗
PubMedDate not supplied

Aztreonam monotherapy as prophylaxis in transurethral resection of the prostate: a multicenter study.

The efficacy and safety of aztreonam in the prophylaxis of urinary tract infection following transurethral resection of the prostate (TURP) in patients with preoperatively sterile urine were studied in a multicenter trial including 300 patients at six Italian urology centers. The present report describes the first 192 patients enrolled in the protocol. Aztreonam or placebo was administered to each patient in three doses, which were given at the induction of anesthesia and 8 and 16 hours later. The development of bacteriuria was monitored by cultures of urine obtained before surgery, 3 days later, at removal of the bladder catheter, at discharge from the hospital, and at a follow-up visit 39-46 days after surgery. A febrile peak was observed for 6% of aztreonam-treated patients and for 20.9% of the placebo group (P less than .005), while bacteriuria was reported in 17.9% and 59.3% of these groups, respectively (P less than .001). From our data, TURP appears to be a clean-contaminated procedure requiring antibiotic prophylaxis, and aztreonam appears to reduce significantly the incidence of postoperative bacteriuria after this surgical procedure.

Adult↗