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Biomedical subjects

S Rosenstein

Publications and source records attributed to S Rosenstein.

7 recordsLinked to original sources
PubMed1991

Orthognathic surgery in cleft patients treated by early bone grafting.

For the past 25 years at Children's Memorial Hospital in Chicago a protocol has been followed for complete clefts that involves placement of an infant maxillary orthopedic appliance prior to lip closure, surgical closure of the lip, autogenous split-rib grafts to the alveolus to stabilize maxillary segments, and palatal closure, generally within the first year of life. The oldest 36 patients whose skeletal growth was for all practical purposes finished have been followed to determine the need for and type of orthognathic surgery. Of the total sample, 8 patients (22.2 percent) required some type of sagittal orthognathic surgery (1 patient in this group also required vertical maxillary alignment) and 2 patients required maxillary augmentation only in the form of an onlay graft. This report may serve as a baseline for others who wish to report on the incidence and type of orthognathic surgery in their cleft palate centers.

Adolescent↗
PubMed1991

The case for early bone grafting in cleft lip and palate: a second report.

In 1982, the first long-term study of our early bone-grafting and infant maxillary orthopedic approach to newborn complete clefts of the lip, alveolus, and palate was published. The protocol and sequence of procedures were shown on the first 16 consecutively treated orthodontic patients, with a mean age of 14 years. Cephalometric analysis evaluated anteroposterior and vertical facial growth. This report follows the next 37 consecutively treated individuals in a similar manner and includes not only 20 complete unilateral clefts, but also 17 complete bilateral clefts. Results, when evaluated alone and in comparison with the original series, show once again that there are no adverse growth restraints and that early primary bone grafting in our protocol leads to teeth in better overall occlusion than if it had not been undertaken.

Adolescent↗
PubMed1980

Microcalorimetric assay of acetylcholinesterase.

Comparative assays were made in a spectrophotometer and a microcalorimeter for the reaction between acetylcholinesterase (EC 3.1.1.7) and acetylthiocholine. The rate of light absorbance change and the rate of heat flow were measured from similar and simultaneous reactions in spectrophotometer and microcalorimeter, respectively. At the enzyme activity levels studied, i.e., 0.05-0.15 I.U. in calorimetry and 1-4 I.U. in spectrophotometry, the reaction rates were linear and showed first-order kinetics A highly significant positive correlation was seen between the two methods (r = 0.997). More importantly, spectrophotometric assay with acetylthiocholine (which utilized a secondary reaction with chromagen, dithiobisnitrobenzoic acid) stood in highly significant positive correlation with calorimetric assays (which did not require a chromagen) either with the same substrate (r = 0.976) or with acetylcholine (r = 0.900). It appears that microcalorimetry can be used in preference to spectrophotometry for enzyme kinetic studies to overcome the complexity of reaction mixture and interference problems and with the advantage of using natural substrates.

Acetylcholine↗
PubMed1975

Orthodontic and bone grafting procedures in a cleft lip and palate series: an interim cephalometric evaluation.

An attempt is being made to observe the facial and dental development of a cleft lip and palate sample. The study is continuing and, hopefully, offers insight into what happens to these children who have undergone the placement of a dentofacial maxillary orthopedic appliance early at the time of lip closure and an additional surgical procedure and autogenous osteoplasty. Though the final answers to the two previously posed questions are not yet available, we are able to make some value judgments by observing the lateral cephalometric films of these children, and observing their occusion intraorally. Thus far, we are able to state that in our sample, using our treatment procedures in the sequence advocated, we have seen no growth attenuation in the posterior/anterior dimension. The maxilla, at least to the ages observed, does not appear to have been attenuated by our procedures. Further, it would seem that after a limited first phase of orthodontic treatment to align dental units, the degree of crossbite is considerably smaller from that reported in the literature by those using more conventional approaches; thus it is possible that we are doing some good. We are still using these procedures on our newborn and continue to feel that we have a real opportunity to be able to do more orthodontically for these children when they possess a full, permanent dentition and are ready for comprehensive treatment.

Bone Transplantation↗