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S Rusmin

Publications and source records attributed to S Rusmin.

7 recordsLinked to original sources
PubMed1977

Effect of inline filtration on the potency of drugs administered intravenously.

The binding of cephalothin sodium, phenobarbital sodium, dexamethasone sodium phosphate, isoproterenol hydrochloride, digoxin, dactinomycin and phenytoin sodium to three intravenous inline filters--a 5-micrometer stainless steel depth filter, a 0.2-micrometer cellulose ester membrane and a 0.2-micrometer polycarbonate membrane--was studied. The experiments were conducted simulating inline i.v. filtration of these drugs in three i.v. solutions--lactated Ringer's, 5% dextrose and normal saline. Cephalothin was assayed colorimetrically, phenobarbital and phenytoin spectrophotometrically, and the other drugs by radiotracer technique. Binding of the drugs to the filter was found to be insignificant from a therapeutic standpoint, except for dactinomycin which bound to the 0.2-uicrometer filters. The binding of dactinomycin was approximately 13% of the amount administered through cellulose ester and polycarbonate membranes, respectively. The binding occurred during the initial period of filtration of the drug solution. It was concluded that inline filtration of drugs administered in relatively high does should not present any problem concerning the reduction of the therapeutic potency because of filtration.

Cephalothin↗
PubMed1975

Consequences of microbial contamination during extended intravenous therapy using inline filters.

A study was conducted to determine: (1) the effectiveness of 0.22-mum and 0.45-mum pore size membrane filters in retaining microorganisms over a period of 72 hours of intravenous fluid administration; (2) the growth and multiplication characteristics of microorganisms retained on the filter; and (3) the possibility of pyrogens being released by microorganisms trapped on the filter. Lactated Ringer's injection was used as the i.v. solution. The 0.45-mum filter was found to be effective in retaining all microorganisms studied for at least 6 hours. However, Esherichia coli and Pseudomomas aeruginosa began passing through the 0.45-mum filter between 6 and 8 hours after seeding. All other microorganisms (Candida albicans, Citrobacter freundii, Klebsiella pneumoniae, Staphyloccus aureus) were retained for at least 72 hours. None of the microorganisms passed through the 0.22-mum filter during the 72-hour study period. With viable microorganisms on the filter for 72 hours, no detectable endotoxins or pyrogens were found in the filtrates as examined by the limulus and rabbit tests.

Animals↗
PubMed1975

Effect of antibiotics and osmotic change on the release of endotoxin by bacteria retained on intravenous inline filters.

A study was conducted on the effects of two antibiotics (gentamicin and carbenicillin) and of a sudden change from an isotonic to a hypotonic solution on the release of endotoxin by three gram-negative bacteria(Esherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa) growing on a 0.22-mum pore size membrane filter. During a 72-hour constant flow of sterile lactated Ringers's solution through the contaminated filters, no endotoxin was released into the filtrates as tested by the coagulation of Limulus amebocyte lysate. However, flushing the filters with carbenicillin or gentamicin killed the bacteria and caused the release of endotoxin into the filtrates. A sudden osmotic change (flushing the filter with water) did not kill the bacteria nor cause the release of endotoxin into the filtrate.

Carbenicillin↗
PubMedDate not supplied

Decontaminating agents.

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Anti-Infective Agents↗