Biomedical subjects
Publications and source records attributed to S S Barron.
Anorectal neurilemomas are uncommon. We report two patients, one with a perirectal neoplasm and another with a perianal tumor. The lesions were solitary, with no evidence of generalized neurofibromatosis in either. The literature on this subject is reviewed.
Methylglyoxal bis-dihydrochloride is a drug that has been available for use in cancer chemotherapy since 1955. In earlier studies, it was used on a daily schedule with resulting severe gastrointestinal toxicity and myelosuppression. To avoid that toxicity, a new weekly schedule has been adopted in several Phase II studies. With the weekly schedule, new types of toxicity have been described and we report four patients who have developed a severe sensory-motor neuropathy with the chemotherapy which appears to be drug-related.
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