Somber perspective for dermatology.
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Dermatology↗
Biomedical subjects
S S Berger
Publications and source records attributed to S S Berger.
Mandibular hypoplasia secondary to perinatal trauma: report of case.
A case of unilateral mandibular hypoplasia is presented. Considerations regarding a differential diagnosis of hemifacial microsomia or traumatically induced ankylosis of the temporomandibular joint are discussed. Although the described malformations might suggest a diagnosis of hemifacial microsomia, the history and clinical findings tend to support the conclusion that the asymmetry was caused by damage to the temporomandibular joint at an early age.
Birth Injuries↗
Interleukin-6-associated inflammatory processes in Alzheimer's disease: new therapeutic options.
The cytokine interleukin-6 is consistently detected in the brains of Alzheimer's disease patients but not in the brains of nondemented elderly persons. Until recently it was unclear whether an interleukin-6-associated inflammatory mechanism is an early or late event in the pathological cascade of Alzheimer's disease. We investigated whether interleukin-6 could be detected in plaques of Alzheimer's disease patients prior to the onset of neuritic degeneration. We found interleukin-6 mostly in plaques where neuritic pathology has not yet developed. This indicates that the appearance of interleukin-6 may precede neuritic changes and is not just a consequence of neuritic degeneration. Therefore, one may hypothesize that activation of inflammatory mechanisms may cause neuritic degeneration in plaques. A suppression of interleukin-6 synthesis could, therefore, be of therapeutic value. Upon screening a number of substances, we found that a small number of nonsteroidal antiinflammatory drugs, including tenidap, were able to inhibit interleukin-6 synthesis in cultured human astrocytoma cells. These substances may be therapeutically useful in Alzheimer's disease and should be evaluated in clinical studies.
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