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Biomedical subjects

S S Berman

Publications and source records attributed to S S Berman.

47 records · Page 3Linked to original sources
PubMed1991

Electrospray mass spectrometry: application of ion evaporation theory to amino acids.

We describe the result of applying the ion evaporation theory to a series of amino acids. The very good correlation (r = 0.98) of the natural logarithms of protonated molecule intensities observed by electrospray with the difference between the hydration free energies of molecules and the gas-phase binding free energies of molecules and protons in amino acids is consistent with the ion evaporation model. It seems that the difference in the protonated molecule intensities of amino acids obtained by electrospray can be explained by a scheme in which protonated molecules in the liquid phase are extracted into the gas phase after a charged droplet is formed.

Amino Acids↗
PubMed1990

Disseminated histoplasmosis with embolic endovascular complications: a case report.

A 57-year-old man had subacute embolic ischemia of his right foot and subsequent acute embolic ischemia of his left foot after angiography. Thrombus removed at the time of the left femoral thromboembolectomy grew Histoplasma capsulatum confirming the diagnosis of disseminated histoplasmosis. Surgical revascularization of the right leg and parenteral amphotericin B was followed by chronic ketoconazole therapy for 16 months. The patient has remained asymptomatic at 30 months after operation. Effective treatment of endovascular infection with ischemic complications of Histoplasmosis requires surgical revascularization and intensive chemotherapeutic intervention. Histoplasmosis is a ubiquitous infection in endemic areas that often has an asymptomatic subclinical course. Involvement of the cardiovascular system is rarely reported. Previous case reports have described infected cardiac valves and aortic aneurysms. This report describes the uncommon presentation of disseminated Histoplasma capsulatum infection as a peripheral embolic event and the successful management with revascularization combined with systemic amphotericin B followed by ketoconazole therapy.

Histoplasmosis↗
PubMedDate not supplied

Pulmonary embolism following hemodialysis access thrombolysis/thrombectomy.

PURPOSE: The increased use of thrombectomy with deliberate pulmonary embolization of thrombus following initial thrombolysis for occluded hemodialysis fistulas prompted the authors to measure the prevalence of pulmonary embolism (PE) due to the procedure. PATIENTS AND METHODS: Thirty-one patients with 43 acutely thrombosed polytetrafluoroethylene hemodialysis fistulas were treated with thrombolysis/thrombectomy. Perfusion lung scans were obtained in 22 patients. Patients were also continuously monitored for clinical signs or symptoms of PE. RESULTS: Perfusion scans were interpreted as consistent with PE in 59% of those studied, but no clinical signs or symptoms were present in 41 of the 43 cases (95%). However, two patients developed both signs and symptoms of acute PE in the postprocedural period and died. One had underlying pulmonary disease and had undergone thrombectomy before. The other had chronic heart disease. CONCLUSION: Thrombolysis/thrombectomy is usually safe and effective, even though many patients develop subclinical PE. The authors urge extreme caution in patients who have underlying pulmonary or cardiac disease and/or have undergone the procedure before.

Adolescent↗
PubMedDate not supplied

Stent versus endovascular graft healing characteristics in the porcine iliac artery.

PURPOSE: To evaluate the healing characteristics of stents versus endovascular grafts in the porcine iliac artery. MATERIALS AND METHODS: A total of 20 iliac arteries in 10 domestic swine were used to evaluate the healing characteristics of stents versus endovascular grafts. Each animal received one stent and one endovascular graft in opposite iliac arteries. The endovascular grafts were constructed with use of 6 cm of expanded polytetrafluoroethylene (ePTFE) (3 mm inner diameter, 30 microm internodal distance) and Palmaz stents (P204 or P188) secured at each end of the graft. A solitary Palmaz stent (P308 or P294) was used on the opposite side. The devices were explanted at 1, 5, and 12 weeks. RESULTS: One of three endovascular grafts and two of three stents were patent at 1 week. Two of three endovascular grafts and all three stents were patent at 5 weeks. All three endovascular grafts and stents were patent at 12 weeks. Gross examination, histologic, and scanning electron microscopy demonstrated differences in the healing response of the two devices. A marked abluminal inflammatory response to the graft material was observed. This resulted in neovascularization of the tissue along the abluminal surface of the graft. In addition, marked neointimal thickening at the unsupported section of the endovascular graft resulted in significant luminal narrowing. CONCLUSION: The porcine model may be used for evaluating the healing characteristics of endovascular grafts. Intravascular placement of ePTFE prosthetic graft material dramatically alters the healing of this type of graft material. The graft material did not prevent the formation of a progressively thickening neointima.

Animals↗
PubMedDate not supplied

Inflammation and neovascularization associated with clinically used vascular prosthetic materials.

This study was designed to evaluate and compare healing characteristics, specifically neovascularization and inflammation, of polymeric vascular graft materials commonly used in clinical applications. Our hypotheses were (i) polymeric materials used in vascular graft manufacture stimulate chronic inflammation and (ii) inflammation and neovascularization of polymeric materials are related. Impra and Gore-Tex ePTFE, Meadox weavenit and woven Dacron, Hemashield microvel and woven Dacron, and Golaski microknit Dacron were implanted as 6-mm diameter disks within rat subcutaneous and adipose tissue. Following 5 weeks of implantation samples were evaluated by histological and immunocytochemical analysis. Sections were stained using hematoxylin and eosin or reacted with ED1 antibody and GS1 lectin to quantify inflammation and neovascularization. respectively. The extent of inflammation and neovascularization were influenced by both tissue site of implantation and polymer characteristics. For subcutaneous implants, inflammation was graded as follows: Meadox weavenit > Hemashield woven > Meadox woven > Gore-Tex ePTFE > Hemashield microvel > ImpraePTFE > Golaski microknit, while only the Golaski microknit neovascularized. Inflammation was graded as follows for adipose implants: Hemashield woven > Hemashield microvel > Meadox weavenit > Meadox woven > Gore-Tex ePTFE > Golaski microknit > Imnpra ePTFE, while the following order of neovascularization was observed: Impra ePTFE > Gore-Tex ePTFE > Golaski microknit. The degree of inflammation following biomnaterial implantation has a profound effect on implant neovascularization. These data suggest an inverse relationship exists between inflammation and neovascularization.

Adipose Tissue↗