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S S Fajans

Publications and source records attributed to S S Fajans.

At least 73 records · Page 4Linked to original sources
PubMed1976

Glucagon release precedes insulin release in response to common secretagogues.

UNLABELLED: The dynamics and interrelationships of glucagon and insulin secretion were studied in the isolated perfused rat pancreas by utilizing a series of compounds that stimulate the release of both hormone. Leucine, arginine, prostaglandins F2alpha and E2, bovine growth hormone, and isoproterenol were administered individually over 60-second intervals. The release of glucagon preceded that of insulin in response to all compounds tested. The rapidity of glucagon release varied in response to different secretagogues; the time course of insulin release was fairly constant. The timing and the magnitude of glucagon and insulin release did not correlate statistically. CONCLUSIONS: (1) pancreatic alpha cells respond more rapidly than beta cells to the same stimulus; (2) antecedent release of glucagon is not the principal mediator of insulin release in response to stimuli common to both hormones; and (3) endogenous glucagon may at best modify the release of insulin evoked by certain secretagogues.

Amino Acids↗
PubMed1976

The various faces of diabetes in the young: changing concepts.

Diabetes included several disorders associated with hyperglycemia. A difference in inheritance between the families of juvenile-onset- and maturity-onset-type diabetics, provides evidence for genetic heterogeneity. Heterogeneity of insulin responses to glucose was foung among nonobese patients with maturity-onset-type diabetes. Prospective studies in young patients have shown that glucose intolerance may not progress for as long as 22 years and that subnormal insulin responses to glucose have not decreased further, up to 12 years. However, patients who progressed to diabetes requiring insulin had insulin responses that were subnormal or below the control mean. None whose insulin responses exceeded this mean have decompensated. Thus, insulin response to glucose has prognostic implications. A tentative classification of diabetes in the young is proposed. There was a significant correlation between muscle capillary basement membrane width and known duration of carbohydrate intolerance.

Adolescent↗
PubMed1975

A difference between the inheritance of classical juvenile-onset and maturity-onset type diabetes of young people.

A difference in the inheritance of diabetes has been shown between the families of twenty-six patients with maturity-onset type diabetes of young people (MODY) and families of thirty-five patients with classical juvenile-onset diabetes (JOD). In the families of MODY: 1) twenty-two of twenty-six (85 per cent) propositi had a diabetic parent; 2) 46 per cent of families showed direct vertical transmission of diabetes through three generations; 3) of forty-seven tested siblings twenty-five (53 per cent) had latent diabetes; 4) the diabetic phenotype in the families was consistent, most affected individuals having a noninsulin requiring type of disease. These findings are compatible with autosomal dominant inheritance of MODY, although they do not exclude multifactorial inheritance. In contrast, in the families of JOD: 1) only four (11 per cent) of propositi had a diabetic parent; 2) three generation inheritance was found in only two (6 per cent) of JOD families, and 3) of seventy-four tested siblings eight (11 per cent) were diabetic. This difference provides further evidence of genetic heterogeneity in diabetes mellitus and indicates that there is a need for careful definition of the phenotype of diabetes in populations in which the genetics of diabetes is to be analyzed. Diabetes 24:44-53, January, 1975.

Adolescent↗
PubMed1975

Prevalence of diabetes and glucose intolerance in 199 offspring of thirty-seven conjugal diabetic parents.

We have studied the prevalence of diabetes and glucose intolerance, both cross-sectionally and longitudinally, in a cohort of 199 offspring of conjugal diabetic parents. Although the prevalence of already known diabetes was low (11.5 per cent), twenty-eight of 123 tested offspring (23 per cent), ranging in age from ten to sixty (mean 32.6) years had latent diabetes on their initial glucose tolerance test. Eighty of 123 tested offspring had a normal initial glucose tolerance test. Forty-one of those whose first glucose tolerance test was normal were retested after a mean of 9.4 years and showed no significant change in mean glucose tolerance. On the basis of questionnaire data only, we estimate that cumulatively 36.5 per cent of offspring will have diabetes by the age of sixty years. However, if all offspring are routinely surveyed with glucose tolerance tests, 60 per cent will have abnormal glucose tolerance by the age of sixty years. In view of the high prevalence of asymptomatic latent diabetes, genetic studies of diabetes should not be based on questionnaire data. In six families all offspring were diabetic; in twenty-one families there was a mixture of diabetic and nondiabetic offspring; and in ten none of the offspring was diabetic. The finding of families with no diabetic offspring suggests the possibility of genetic heterogeneity of diabetes in the parents. Most of the parents had maturity-onset diabetes with a mean age at diagnosis of 54.5 years of age. Diabetes among their offspring was generally of a mild maturity-onset type. Only 2 per cent of offspring at risk had developed juvenile-onset type diabetes. Thus the prevalence of any metabolic abnormalities in offspring of two maturity-onset type parents cannot be assumed to be relevant to the offspring of parents with juvenile-onset type diabetes.

Adolescent↗
PubMed1975

Tissue distribution of 14C-, 125I-, and 131I-diphenylhydantoin in the toadfish, rat, and human with insulinomas.

Carbon-14-diphenylhydantoin (DPH) concentrated maximally in pancreatic islet cells of the toadfish 10 min after its intravenous administration. The islet cell-to-acinar-tissue ratio at this time was 6:1. The islet cell-to-liver ratio was 20:1. Iodine-125-paroiodo-DPH at 10 min in the toadfish showed an islet cell-to-acinar-tissue ratio of 1.7:1 and an islet cell-to-liver ratio of 2.3:1. When 14C-DPH was given to four patients 10-17 min before removal of norma pancreatic tissue and of an insulinoma in three of the patients, the concentration of radioactivity in the insulinoma was never greater than in the pancreas and concentrations in insulinoma and pancreas were always less than in liver in the same individual. Forty-five to 90 min after administration of 131I-DPH, the liver and pancreas were delineated in three patients but the insulinoma was not imaged. Five days after administration of 131I-DPH, the concentration of 131I radioactivity in excised tissue was greater in the insulinomas than in the pancreas of two patient but not sufficient to produce positive images of the insulinoma in the pancreas.

Adenoma, Islet Cell↗