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Biomedical subjects

S S Fernando

Publications and source records attributed to S S Fernando.

32 records · Page 2Linked to original sources

Pseudomelanosis duodeni: a case report with electron-probe X-ray analysis.

Pseudomelanosis of the duodenum is rare. Only 17 cases have been documented in the world literature. A 59-year-old man presented to Bankstown Hospital, New South Wales with dysphagia. On endoscopy, he was found to have melanosis of the duodenum in addition to oesophageal ulceration. It has been previously suggested that the pigment ferrous sulphide is derived from gastro-intestinal bleeding and lodged in the macrophages. A detailed examination of the pigment, including X-ray probe micro-analysis at various levels of the intestinal epithelium as well as in macrophages is presented.

Calcium↗

The giant kidney worm (Dioctophyma renale) infection in man in Australia.

A 47-year-old, previously healthy farmer from Grafton, N.S.W. in Australia, developed loin pain and hematuria 2 months after minor trauma to his loin. A renal cyst was found by ultrasound and arteriography. At operation, a thick-walled cyst containing 800 ml of clotted blood was excised together with a small wedge of kidney. Ring-like structures measuring 70 X 45 mu were found in the fibrous cyst wall and in the surrounding fat. These birefringent double-walled "rings" with equally spaced radial striations were identified as the eggs of Dioctophyma renale.

Animals↗

Aspergillus fumigatus infection of the optic nerve with mycotic arteritis of cerebral vessels.

A 56-year-old Caucasian male, with no obvious immune deficit or systemic disease, presented with unilateral loss of vision due to A. fumigatus infection involving the right optic nerve. There was no proptosis. Despite fungal chemotherapy he developed central nervous system involvement with mycotic arteritis of the branches of the right middle cerebral artery, temporal lobe infarction and rupture of a mycotic aneurysm of the right internal carotid artery, and died. Review of the literature concerning orbital Aspergillus infection showed both this form of presentation and a rapidly fatal course to be unusual.

Arteritis↗

Neuromuscular and vascular hamartoma of small bowel.

Two examples of a hitherto undescribed hamartomatous condition of the small intestine are presented. They consist of fascicles of smooth muscle derived from the muscularis mucosae, bundles of unmyelinated nerve fibres with scattered ganglion cells, and haemangiomatous vessels, occurring focally within a segment of the intestine, and causing stenosis.

Adult↗

The effects of mebendazole and fenbendazole on Trichinella spiralis in mice.

Oral administration of either Mebendazole or Fenbendazole at 50 mg/kg body weight was effective in killing a 7-hr Trichinella spiralis infection in mice. Adult worms, 72 hr postingection, were unaffected by the same dose of Fenbendazole, while Mebendazole showed partial activity. Both Mebendazole and Fenbendazole were active against developing muscle larvae. Mebendazole was effective against encysted muscle larvae while 50 mg of Fenbendazole per kg per day for 7 days from 28 days postinfection failed to have any effect on this stage of the life-cycle.

Animals↗