Biomedical subjects

S S Gelbart

Publications and source records attributed to S S Gelbart.

6 recordsLinked to original sources

PubMed1988

Congenital nystagmus: a clinical perspective in infancy.

In a series of 152 patients with congenital nystagmus, 119 had sensory nystagmus while 13 had pure motor nystagmus. The most common diagnoses in the sensory group were optic nerve hypoplasia. Leber's amaurosis, and oculocutaneous or ocular albinism. Eight of the patients in the motor group had a similarly afflicted parent. Diagnostic features in infants and preverbal children were reviewed. This study supports the continued clinical classification of congenital nystagmus into sensory and motor subtypes.

Albinism↗

PubMed1984

Vertical nystagmus in infants with congenital ocular abnormalities.

In a series of 131 patients with congenital nystagmus, nine patients initially presented with vertical nystagmus associated with congenital ocular abnormalities. Four patients initially presented with upbeating nystagmus. All four of these patients had Leber's amaurosis. The upbeating nystagmus became horizontally directed in three of the four patients prior to one year of age. The other patient is now eight years old and upbeating nystagmus persists. CT scanning reveals cerebellar vermis hypoplasia in this patient. Five patients with albinism in this series presented initially with seesaw nystagmus. In two cases this resolved to one year of age, but in the other three cases, it is still intermittently seen in children ranging in age from two and a half to five years old. Vertically directed nystagmus may be associated with some ocular abnormalities in infancy and is not always a sign of isolated neurologic disorders.

Cerebellum↗

PubMed1982

Long-term visual results in bilateral congenital cataracts.

In 24 infants who underwent surgery for bilateral congenital cataracts, 29 eyes (60%) achieved visual acuities of 6/18 (20/60) or better and 13 (27%) had visual acuities of 6/60 (20/200) or worse. The best results occurred in patients who underwent surgery before they were 8 weeks old. Only one patient of the seven operated on after the age of 8 weeks achieved a visual acuity of better than 6/60 (20/200). These favorable visual outcomes were the result of early surgery, short intervals between operations on fellow eyes (48 hours or less), total bilateral occlusion between operations, careful postoperative monitoring with retinoscopy and visual-evoked potentials, and early correction of aphakia.

Age Factors↗

PubMed1980

Effect of marihuana on intraocular and blood pressure in glaucoma.

Marihuana inhalation was accompanied by increased heart rate and decreased intraocular and blood pressure in 18 subjects with heterogenous glaucomas. The hypotensive effects appeared in 60 to 90 minutes as the decrease in intraocular pressure (IOP) appeared to follow the decrease in blood pressure. In addition to any local effect, the mechanism of lowered to any local effect, the mechanism of lowered IOP may also involve the decreased pressure perfusing the ciliary body vasculature as a result of the peripheral vasodilatory properties of marihuana. Postural hypotension, tachycardia, palpitations, and alterations in mental status occurred with such frequency as to mitigate against the routine used in the general glaucoma population. Our data indicate that further research should be directed to local means of delivering the ocular hypotensive cannabinoid to the glaucomatous eye.

Adult↗

PubMed1978

Automorphic L-functions of half-integral weight.

We describe a theory of Whittaker models and L-functions for irreducible representations of a metaplectic covering group of GL(2). We explain how to use these L-functions to establish an arithmetical correspondence between "genuine" cuspidal representations of the metaplectic group and cuspidal representations of GL(2). When our ground field is Q, this correspondence generalizes and reformulates recent results of G. Shimura [(1973) Ann. Math. 97, 440-481]. A crucial role in our theory is played by what we call "exceptional" cusp forms-those that are completely determined by just one Fourier coefficient.

Journal Article↗

PubMed1970

Fourier Analysis on GL(n,R).

Two problems of Fourier analysis on GL(n,R) are studied. The first concerns the decomposition of the additive Fourier operator in terms of the group representation theory of G. The second concerns the analytic continuation of certain zeta-functions defined on G. It is found that the generalized Gamma functions of Gelfand and Graev arise naturally in the solution of both these problems.

Journal Article↗