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S S Markarian

Publications and source records attributed to S S Markarian.

At least 19 recordsLinked to original sources
PubMed1991

[Comparative study of the effect of drug therapy and its combination with hyperbaric oxygenation and hemosorption on stable angina pectoris].

Seventy seven males aged under 60 years with Functional Classes II-IV stable angina were examined. The patients were randomly divided into 3 groups: 1) 24 patients receiving drug therapy alone; 2) 27 patients taking drug therapy in combination with hyperbaric oxygenation; and 3) 26 patients having drug therapy in combination with hemosorption. In all the patient groups, there was a reduction in the frequency of resting and exercise anginal attacks, in Group 3, exercise tolerance was increased due to drug therapy. In a re-examination, there was a significant fall in total cholesterol and high-density lipoprotein cholesterol levels only in Group 3. A comparison of daily drug doses indicated that the functional class improved only due to the adequate antianginal therapy. Thus, hyperbaric oxygenation and hemosorption have no significant action on the degree of stable angina.

Adult↗
PubMed1986

[Effect of physical loading on serum enzyme activity in post-myocardial infarct patients].

The study of patterns of serum AST, ALT, CPK, LDH, and glycogen phosphorylase (GP) activity following bicycle ergometry in 26 male patients 1 to 1.5 months after myocardial infarction demonstrated no increase in AST, ALT and CPK activity, whereas total LDH activity was increased, with a tendency to elevated LDH-1 and LDH-2 fractions, as compared to the baseline, in those cases where exercise was discontinued because of ST depression. Patients with favorable response to bicycle ergometry that continued until the submaximum heart rate for a given age was achieved showed a tendency to elevated LDH-5 that may be a physiological response to exercise. The demonstrated increase in total GP activity, both in patients with exercise-induced ST depression and in those with elevated ST from the leads corresponding to the site of myocardial infarction, may reflect stress-induced reversible ischemia.

Adult↗
PubMed1984

[Left ventricular function in patients who have had a myocardial infarct, based on echocardiographic study data].

The significance of a combined echocardiographic study of patients who survived myocardial infarction for evaluation of ventricular hemodynamic disturbances was shown. According to the ultrasonic B-scanning data the left ventricular end-diastolic and endsystolic volumes in such patients were increased, and ejection fraction values, delta S and VCF were markedly decreased. The most pronounced left ventricular pump and contractility dysfunctions occurred in transmural and anterior myocardial infarctions. During M-mode echocardiography in patients with posterior wall hypokinesia, the prolongation of isovolumic relaxation and contraction followed by the shortening of rapid filling was observed. A significance correlation between the prolongation of isovolumic relaxation and polygraphic T interval was found. The thinning of the left ventricular hypokinetic posterior wall was observed during the ejection period, and that of hypokinetic ventricular septum was seen within the cardiac cycle. The signs of more marked left ventricular dilatation with its decreased contractility were found in patients with systolic murmur recorded soon after myocardial infarction development. Such a murmur phonocardiographically recorded was a sign of mitral valve insufficiency.

Diastole↗
PubMed1983

[Central hemodynamics during long-term physical training of patients after myocardial infarction].

Left-ventricular function under the effect of regular exercise was examined in post-infarction patients. Ultrasonic B-scanning technique was used to investigate 49 patients doing regular exercise and 34 control patients. The duration of an exercise course was 9-9.5 months. It was demonstrated that long-term physical training resulted in favourable changes in terms of left-ventricular propulsive capacity, whereas control patients showed deterioration of their pumping and contractile functions. The results are vet another evidence that the effect of exercise is necessarily mediated by the heart as the central link of circulation.

Adult↗
PubMed1979

[Functional state of the left ventricle in patients who have had a myocardial infarct according to ultrasonic scanning data].

In most patients who had suffered from myocardial infarction 3 1/2 to 12 months (7.6 months on the average) previously and had no clinical symptoms of circulatory insufficiency, ultrasonic scanning of the heart showed normal stroke volume and stroke index, and normal minute volume and cardiac index against the background of low indices of left ventricular contractility function (ejection fraction, % delta S, VcF) and large end-diastolic and end-systolic left ventricular volumes. Normal stroke ejection was achieved due to an increase of the end-diastolic volume, the decrease in the contractility of the left ventricular was thus compensated for with the participation of the Frank-Starling mechanism.

Adult↗