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Biomedical subjects

S S Markin

Publications and source records attributed to S S Markin.

15 recordsLinked to original sources
PubMed2003

[Tumor necrosis factor in blood plasma and morphofunctional parameters of the hart in patients with chronic heart failure complicated by a course of ischemic heart disease. Dynamics under effect of treatment].

AIM: To examine the course of chronic cardiac failure (CCF), morphofunctional parameters of the heart in correlation with activity of cytokine system; to evaluate effectiveness, tolerance and safety of combined CCF treatment including a cardioselective beta-adrenoblocker bisoprolol in patients with CCF FC I-IV having a high plasm level of tumor necrosis factor alpha (TNF-alpha). MATERIAL AND METHODS: The concentration of TNF-alpha in plasm of 40 patients with IHD complicated by CCF of FC I-IV and ejection fraction under 45% was measured at enzyme immunoassay. The treatment included combined therapy with diuretics, cardiac glycosides, peripheral vasodilators, ACE inhibitors, bisoprolol (group I) or no bisoprolol (group II). RESULTS: CCF patients with TNF-alpha had a significantly reduced IMT, more frequent episodes of CCF decompensation, longer CCF history, lower EF and threshold exercise intensity. In group I patients all these parameters improved. CONCLUSION: CCF patients with elevated plasm levels of TNF-alpha showed a severe course of the disease, low IMT, abnormal myocardial contraction and exercise tolerance. The addition of bisoprolol to combined treatment of the above patients improves their clinical condition, morphological parameters of the heart and exercise tolerance.

Aged↗
PubMed1993

[Value of rapid biopsy in diagnosis of thyroid cancer].

Patients with thyroid carcinoma (ThC) in 67% are erroneously operated on with the diagnosis of nodular struma, this resulting in the recurrences in 30% and mortality and complications reaching 42%. Since 1977 the authors were performing rapid biopsies in all cases of the euthyroid struma and this resulted in the proper diagnosis in 98% of operated patients (48.6% before this). Short-term examination consists of stereo-morphology of the surgical material and the preparation by means of the deep frozen knife, of the histo-topographical section stained by Harris hematoxylin. Microcarcinomas are revealed by this method 30 times more frequently than in routinely treated sections. Short-term biopsy of the thyroid is as necessary as it is in the mammary gland lesions.

Biopsy↗
PubMed1992

[Content of cholesterol extracted from human skin surface--a possible discriminant of atherosclerosis?].

Basing on the data of Bouissou et al. on an increase of cholesterol content in the skin biopsies in atherosclerosis patients, the cholesterol amount was evaluated after superficial atraumatic rapid treatment of patients palm skin. The optimization of the extraction conditions was performed: the surface skin cholesterol value was constant for individual subjects (variability factor 5%). The range of this value was 1.5-6 Mg/cm2 and it was higher for atherosclerotic patients. No correlations with any conventional plasma lipoprotein parameters were observed. At the same time positive correlation (r = 0.54. p < 0.01) was observed with dyslipoprotein coefficient--(Ch+TG/alpha-Ch). Possible diagnostic significance of this skin cholesterol parameter is discussed.

Biopsy↗
PubMed1992

[Pathomorphology of the thyroid gland (based on emergency biopsy)].

The term "struma" denotes any increase of the thyroid volume and weight regardless of its nature. In no other organ there are so frequent polymorphic structures stimulating neoplastic growth. This does not allow for a wide use the diagnosis of early thyroid carcinoma. Differentiation of the thyroid lesions is to a great extent possible due to stereomorphologic and rapid histotopographic study of surgical material with its subsequent embedding into paraffin. Nodular and adenomatoid struma was found in 60%, follicular adenomas in 11% cases among 20,000 operated patients with euthyroidism in a non-general endocrinological department. Thyroid carcinoma represented 5% and autoimmune thyroiditis in 4% while before the operation they were diagnosed in 1% cases only. Microcarcinoma among routine biopsies was revealed every year 10-15 times more rarely than among urgent histotopographic biopsies. Thus it is advisable to use more widely intraoperative biopsies in euthyroid diseases with subsequent comparison to postoperative histological findings.

Biopsy↗
PubMed1990

LDL-apheresis on affine haemosorbents.

There were synthesized new hemosorbents for selective removal of LDL, based on macroporous silica, immobilised by heparine (sorbent 1) and chytozane-sulphate (sorbent 2). Experimental data showed satisfactory hemo- and biocompatibility of the new sorbents. No significant alterations in biochemical parameters were observed. Sorption cholesterol (Ch) capacity of the sorbents was equal and accounted for 15 mg of Ch per 1 g of the sorbent. Pilot clinical studies in familial hypercholesterolemia (FH) patients have shown the satisfactory hemo- and biocompatibility of the sorbent 1, and its significant Ch withdrawal. We conclude that the hemosorbents can be used in the FH patients treatment.

Adult↗
PubMed1990

[Ceruloplasmin-transferrin antioxidant system in in experimental and clinical atherosclerosis].

The antioxidative system (AOS) ceruloplasmin-transferrin (Cp-Tr) was studied by means of electron paramagnetic resonance in 14 rabbits with experimental atherosclerosis and in 33 patients with ischemic heart disease (IHD). A correlation was found between the AOS Cp-Tr activity and the pathological process severity: mild disease was associated with high AOS activity, while in severe disease course, this activity was threefold lower. This regularity was detectable both in experimental animals and in human IHD patients. It was found that hemosorption (HS) exerted a positive effect only in the presence of low AOS Cp-Tr activity which increased after HS in these cases. In high AOS activity HS caused deterioration of the patients' condition and accumulation of lipid peroxidation products in the blood plasma; this was attended with lowering of the AOS Cp-Tr activity.

Adult↗
PubMed1989

[Secondary atherosclerotic immunodeficiency].

A study of peripheral and central mechanisms of secondary immunodeficiency in atherosclerotic patients demonstrated altered structural layout of lymphocyte membranes due to cholesterol accumulation in the cells. This was associated with increased membrane viscosity, suppressed mitotic activity and lower cap formation rate as well as changed intracellular calcium redistribution. Thymic ischemia due to occlusion or stenosis of thymus-supplying vessels was shown to promote age-related transformation of thymic tissue. Experimental simulation of thymic ischemia resulted in an abrupt drop of serum thymic factor in the blood of animals and the development of an immunodeficient condition.

Animals↗
PubMed1989

[Preparation of histotopographic goiter sections and endometrium scrapes for relevant instant diagnosis].

Histotopographic examinations of goiters and scrapes taken as a whole are valuable to the emergency pathomorphological diagnosis of thyroid and endometrial diseases essential particularly for the differentiation of adenomas and well differentiated carcinomas. The examination can be carried out only by treating fresh, non-fixed materials with a deeply cooling knife of the routine cold microtome (Model X). Harris' or Ballard's hematoxylins are best used as elective dyes. The whole instant diagnosis fully described in the paper lasts 8 to 12 minutes.

Diagnosis, Differential↗
PubMed1987

The programmatic hemosorption in the comprehensive treatment of atherosclerosis of various localization. Hemosorption in the treatment of atherosclerosis.

The inclusion of hemosorption through activated coals into the comprehensive treatment of 580 patients sick with atherosclerosis has made it possible to achieve a positive clinical effect among 81 per cent of the patients sick with the ischemic heart disease, 79 per cent of atherosclerotic discirculatory encephalopathy and 76 per cent of obliterating atherosclerosis of lower limbs. The positive dynamics is especially visible among patients who are administered the programmatic hemosorption, making it possible over a long period of time (3-5 years) to sustain remission in the clinical state and the normal level of the lipids in the blood. The direct effect is expressed in the improved microcirculation, disappearance of the sludge-syndrome and the reduction of ischemic disorders. The remote effect of hemosorption is connected with the repeated removals of cholesterin of the atherogenic lipoproteids, which leads, we believe, to the interruption or even regression of the atherosclerotic process.

Arteriosclerosis↗
PubMed1985

[Extraction of cholesterol from biological membranes with positively charged micelles of phosphatidylcholine].

The content of cholesterol in red cell and platelet membranes was lowered in rabbits with experimental atherosclerosis after intravenous injection of positively charged micelles of soybean phosphatidylcholine. That lowering was accompanied by a reduction in membrane microviscosity, rise of the activity of Na,K- and Ca-ATPases of red cells, and a decrease in the rate of the ADP- and collagen-induced platelet aggregation. Injection of phosphatidylcholine gave rise to an increase in the blood serum content of phospholipids and cholesterol in high density lipoprotein fractions, to a reduction in the content of triglycerides and the atherogenicity index, as well as to the lowering of the microviscosity of high density lipoproteins. The aortal area affected by atherosclerotic lesions was 2 times less in the group of animals given phosphatidylcholine.

Animals↗
PubMedDate not supplied

[Extraction of cholesterol from erythrocyte ghosts by phospholipids].

Removal of cholesterol from erythrocyte ghosts by liposomes and micellas of different phospholipids was investigated. It was shown that the positively charged micelles of polyunsaturated phospholipids are the most efficient for cholesterol removal from biological membranes.

Animals↗
PubMedDate not supplied

[Small thyroid cancer].

Thyroid carcinoma was detected in 1132 of 32500 patients undergoing surgery because of goiter. Small thyroid carcinoma (STC) was found in 245 patients (21.6%) and is divided into the following subgroups: 1) local (focal) microcarcinoma-a focus of a pronounced proliferation, dysplasia and fibrosis up to 1 mm in diameter; 2) invasive dwarf carcinoma of 5 to 15 mm in diameter which is not detected by clinical and instrumental methods; 3) intermediate STC, 1 to 5 mm in diameter. STC had a papillary-follicular structure in 88%, the rest were of a oncocytic and parafollicular structure.

Cell Division↗