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Biomedical subjects

S S Papiha

Publications and source records attributed to S S Papiha.

At least 91 records · Page 5Linked to original sources
PubMed1985

Gc (vitamin D binding protein) subtypes in rheumatoid arthritis.

Two hundred and six patients with rheumatoid arthritis were examined for their association with the subtypes of Gc (vitamin D binding protein). In patient groups there is 11% excess of individuals with Gc*2 allele compared to the control group, giving a relative risk of 1.55. This risk increases with the humoral status of the individual. A possible physiological basis between the association of vitamin D binding protein and rheumatoid arthritis is discussed.

Adult↗
PubMed1985

Human leukocyte antigens and circulating immunoglobulin levels in Indian patients with pulmonary tuberculosis.

Histocompatibility antigens (-A, -B and -C loci) and circulating antibodies (IgG, IgM, IgA and IgE) were studied in 63 pulmonary tuberculosis patients and regionally matched healthy volunteers from Uttar Pradesh, India. A previously described association with antigen B15 in an heterogeneous sample of North India was not confirmed but a slight increase of antigen B18 was found. The levels of immunoglobulins in the plasma of these patients showed a significant increase in IgG, IgA and IgE. Although the increased levels of IgG and IgA are in agreement with previous studies, the role of the increased IgE is not clear and needs further investigation. Patients who were antigen B14 and B18 positive tend to show significantly low levels of IgG, which suggests a possible genetic influence on the expression of immunoglobulin levels.

HLA Antigens↗
PubMed1984

Genetic polymorphism of glutamate-pyruvate transaminase and glyoxalase I in Colombia.

Genetic polymorphism of red cell enzymes glutamate-pyruvate transaminase (GPT) and glyoxalase I (GLO) was investigated in five villages of the Colombian Andes. The GPT1 and GLO1 gene frequencies show a considerable range, but compatible to the range of European populations. In both the systems there is slight excess of observed homozygosity suggesting that the infrastructure of the subpopulations may be influenced by inbreeding.

Alanine Transaminase↗
PubMed1984

Serogenetic investigations of two populations of Iran.

Frequencies of 10 polymorphic systems were investigated in two ethnic groups (Turkoman and Bandari) living near the northern and southern borders of Iran, respectively. A further 6 blood group and enzyme systems were also investigated in Bandari alone and 4 in Turkoman alone. 4 out of 10 commonly studied systems (ABO, Rh, AP and Tf) showed significant frequency differences between these populations. Wright's FIS indicates moderate isolation of these groups, and the gene frequency differences are therefore interpreted as indicating the differing origins of these populations.

Blood Group Antigens↗
PubMed1983

HLA antigen frequency in the Koya tribe of Andhra Pradesh, India.

The frequencies of HLA-A, -B, and -C antigens were studied in a tribal population of Koya from Andhra Pradesh in southern India. No other well-defined tribal population has been studied with which the present results may be compared. However, the HLA profile of Koya showed distinct differences from the general HLA distribution in India in the frequency of a large number of antigens both at the A and B loci. This study indicates the distinctiveness of this tribal population and suggests the potential importance of the study of HLA frequencies in tribal groups of India.

Demography↗
PubMed1983

The associations of HLA and other genetic markers with glomerulonephritis.

One hundred and seventy-nine patients with various forms of glomerulonephritis confirmed histologically were tested for HLA A and B antigens: Thirty-four with membranous glomerulonephritis were also typed for DR antigens. One hundred and forty-one of these patients were further tested for blood group, red cell enzyme, and plasma protein systems. The minimal-change and the mesangio-capillary glomerulonephritis showed a significant association with B8 and Bw44 antigens respectively, whereas the membranous nephritis in addition to B8 was also found to be associated with DR3 antigen. Previously described associations with Henoch-Schönlein and Berger's nephritis were not proved. A large group with nonspecific proliferative glomerulonephritis did not show any association with HLA. Among the other single-gene characters studied, a significant association was found with Bf (Factor B or C3 proactivator) and adenosine deaminase, both markers thought to be involved in the immune response. The close association of the markers located on chromosome 6 and glomerulonephritis indicates that there may be an immunological component in the aetiology of the disease. The significance of the various associations found is discussed.

Blood Group Antigens↗
PubMed1983

Some genetic implications of isoelectric focusing of human red cell phosphoglucomutase (PGM1) and serum protein group specific component (Gc): genetic diversity in the populations of Himachal Pradesh, India.

For the study of group specific component (Gc) and phosphoglucomutase (PGM1) polymorphism, isoelectric focusing was performed on eleven tribal and non-tribal populations of Himachal Pradesh, India. They were chosen to illustrate interregional and intraregional variations. The subtype frequencies of these two systems showed clear differences in the genetic constitution of these populations of Himachal at both levels. There is a large increase in the mean heterozygosity (H) for each system by isoelectric focusing over that shown by electrophoresis. Discriminant and distance analyses both suggest that the subtype frequencies provide greater potential for the study of genetic diversity among populations. The data on these additional alleles found by isoelectric focusing are examined for some of their genetic and anthropological implications.

Carrier Proteins↗
PubMed1983

The polymorphism of the vitamin D-binding protein (Gc); isoelectric focusing in 3 M urea as additional method for identification of genetic variants.

Since the last report numerous new DBP (Gc) variants have been observed; at present a total of 84 different mutants can be distinguished. Several of them have similar electrophoretic mobilities and/or isoelectric points of conventional isoelectric focusing (IEF). IEF in polyacrylamide gels in the presence of 3 M urea is a convenient and efficient method for the detection of hidden variation.

Carrier Proteins↗
PubMed1983

Association between phosphoglucomutase (PGM1) and group-specific component (Gc) subtypes and tuberculosis.

The polymorphism of PGM1 and Gc was studied by isoelectric focusing in pulmonary tuberculosis patients and controls. For the Gc system, the phenotypic frequencies did not differ significantly, but the PGM1 system showed a significant difference in the tuberculosis patients compared to controls. The data presented here show the potential of newly developed techniques to distinguish subjects with susceptibility to disease.

Carrier Proteins↗
PubMed1983

Inhibition of lymphocyte transformation by serum from pregnant women: lack of correlation with levels of alpha-fetoprotein.

Lymphocytes from pregnant and non-pregnant women were stimulated with optimal doses of phytohaemagglutinin (PHA) in order to detect any possible suppression of the maternal cellular immune capabilities. No major differences were observed. Similar cultures using lymphocytes from normal healthy individuals were exposed to sera from pregnant and non-pregnant women. A consistent inhibitory influence, more pronounced at the end of gestation, was identified in the sera from pregnant women. No correlation was found between the levels of alpha-fetoprotein in the pregnant sera and the degree of inhibition observed in the cultures.

Female↗
PubMed1983

Response of human peripheral blood lymphocytes in the presence of cord sera: relationship of lymphocyte transformation with number of pregnancies and levels of alpha-fetoprotein.

Peripheral blood lymphocytes were stimulated with various mitogens (PHA, Con A and PWM) and allogenic cells in the presence of cord serum. The cord sera suppressed more effectively certain T cell populations. This immunoregulatory response of cord serum was compared with nonpregnant and pregnant sera from different gestations. Although the cord sera showed significantly higher inhibition compared to normal adult serum but the serum from gravidae in late gestation proved more inhibitory compared to cord serum. No correlation was found between the levels of alpha-fetoprotein (AFP) in the cord sera and the degree of inhibition observed in the cultures. As previously described for pregnant sera the cord serum obtained from women with different numbers of pregnancies did not correlate with the inhibition of cellular proliferation. Our results suggest a possible different suppressor factor in pregnant and cord sera and also excludes the possibility of AFP in cord sera as a suppressor agent of cell-mediated immunity.

Cells, Cultured↗
PubMed1983

Growth in Hyderabad boys of various language groups.

Possible differences in the growth of boys of four language groups were investigated by anthropometric measurements in a sample of 582 boys of documented age from a Hyderabad school. Correlation of all body measurements with age was sufficiently close over the age range studied to allow linear regressions on age to be fitted. Covariance analysis suggested a difference in trunk length, with Telugu speakers having longer trunks than the other language groups, both absolutely and after stature was taken into account.

Adolescent↗
PubMed1982

Population genetics of the group specific component (Gc) and phosphoglucomutase (PGM1) studied by isoelectric focusing.

For the determination of the group-specific component (Gc) and phosphoglucomutase (PGM1) phenotypes, isoelectric focusing was performed on two samples, one of Jat Sikh of northwest India, the other of northeast English. The subtype frequencies of these two systems do not differentiate the two populations sampled. Synthesis of the existing data shows distinct PGM1 and Gc subtype frequencies in various ethnic and racial groups. The anthropological implication of these subtype frequencies is discussed.

Alleles↗