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Biomedical subjects

S S Parmar

Publications and source records attributed to S S Parmar.

At least 109 records · Page 6Linked to original sources
PubMed1975

Analgesic activity of substituted benzylidinohydrazines.

Sixteen substitued benzylidinohydrazines were evaluated for morphine-like analgesic activity by mouse tail-pinch test while aconitine-induced writhing test in mice was used to determine their ability to possess aspirin-like analgesia. All benzylidinohydrazines exhibited analgesic activity where protection against tail-pinch and aconitine-induced writhing response ranged from 16.7-83.3% and 16.7-66.7%, respectively.

Aconitum↗
PubMed1975

Antiinflammatory and antiproteolytic properties of naphthlthiosemicarbazides and cyclized oxadiazoles.

Eight 1-(naphth-1-ylacetyl)-4-substituted thiosemicarbazides and eight 2-(naphth-1-ylmethyl)-5-arylamino-1,3,4-oxadiazoles were synthesized and evaluated for antiinflammatory and antiproteolytic properties. All thiosemicarbazides (100 mg/kg) provided 14-43% protection against carrageenin-induced edema in rats. Cyclization of thiosemicarbazides to oxadiazoles resulted in significant reduction in the antiinflammatory activity. Some of these thiosemicarbazides also possessed low antiinflammatory activity against cotton-pellet-induced granuloma formation and formaldehyde-induced arthritis in rats. Hydrocortisone and oxyphenbutazone, used as reference drugs, exhibited greater antiinflammatory activity. All compounds possessed antiproteolytic activity. The in vitro protection of trypsin-induced hydrolysis of bovine serum albumin, unlike antiinflammatory activity, was greater with oxadiazoles (30-90%) than the precursor thiosemicarbazides (4-50%) at a final concentration of 1 mM.

Animals↗