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Biomedical subjects

S S White

Publications and source records attributed to S S White.

10 recordsLinked to original sources
PubMed1991

Ophthalmologic screening of adults with mental retardation.

Ophthalmological screening was conducted on 113 clients in a work activity center for adults with mental retardation. Thirty-two percent had abnormalities that were neither refractive nor strabismic. We encountered no instance of neglect of current organic ocular disease. However, 37% of clients had at least one eye that either was not within one diopter of emmetropia or that was not corrected to within one diopter of their retinoscopic findings. Ophthalmologists should consider providing screenings in settings familiar to such clients, where they are more likely to be cooperative.

Adult↗
PubMed1989

Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells.

A partial length cDNA encoding farnesyl pyrophosphate synthetase (hpt807) has been isolated from a human fetal liver cDNA library in lambda gt11. DNA sequence analysis reveals hpt807 is 1115 bp in length and contains an open reading frame coding for 346 amino acids before reaching a stop codon, a polyadenylation addition sequence, and the first 14 residues of a poly(A+) tail. Considerable nucleotide and deduced amino acid sequence homology is observed between hpt807 and previously isolated rat liver cDNAs for farnesyl pyrophosphate synthetase. Comparison with rat cDNAs suggests that hpt807 is about 20 bp short of encoding the initiator methionine of farnesyl pyrophosphate synthetase. The human cDNA was cloned into a prokaryotic expression vector and Escherichia coli strain DH5 alpha F'IQ was transformed. Clones were isolated that express an active fusion protein which can be readily observed on protein gels and specifically stained on immunoblots with an antibody raised against purified chicken farnesyl pyrophosphate phosphate synthetase. These data confirm the identity of hpt807 as encoding farnesyl pyrophosphate synthetase. Slot blot analyses of RNA isolated from Hep G2 cells show that the expression of farnesyl pyrophosphate synthetase mRNA is regulated. Lovastatin increases mRNA levels for farnesyl pyrophosphate synthetase 2.5-fold while mevalonic acid, low-density lipoprotein, and 25-hydroxycholesterol decrease mRNA levels to 40-50% of control values.

Amino Acid Sequence↗
PubMed1987

Effects of acute alcohol administration on maternal calcium metabolism and fetal development in mice.

Pregnant C57Bl/10J mice were treated intraperitoneally with alcohol (Group A) or saline (control) on Day 7 of gestation. On Day 7, at 0 hour and again at 4 hour, Group A received 0.020 ml/GM body weight of 25% (v/v) alcohol, while control mice received 0.020 ml/GM body weight of physiological saline. The injection schedule specified corresponds to a specific stage of fetal development, namely gastrulation. On Day 13 of gestation, all animals were placed in individual metabolic cages to monitor both food and water intake and urinary output. The animals were sacrificed on Day 14. Blood was withdrawn and the serum was used for analyses. In addition, resorption sites within the uterine horns were recorded and fetuses examined. Group A animals had significantly lower serum calcium (Ca) than the controls (6.1 +/- 0.7 mG% versus 9.6 +/- 1.6 mG%, P less than .01). By contrast, the same alcohol injected mice had higher serum phosphate (P) than the controls (18.2 +/- 5.9 mG% versus 12.3 +/- 4.0 mG%, P less than .05). Urinary Ca levels were lower (P less than .05) while urinary P values tended to be higher in alcohol injected mothers. Furthermore, Group A mice had litters which were smaller in size, lower in average fetal body weight and had a higher incidence of resorption (18%) than control mice. Examination of the viable fetuses showed that 53% of those from alcohol treated mothers had facial abnormalities while only 12% of the fetuses from the controls looked abnormal. The results indicate that exposure to acute alcohol in this early stage of pregnancy creates disturbances in maternal Ca metabolism, which may be ultimately related to the observed fetal abnormalities.

Abnormalities, Drug-Induced↗
PubMed1985

Use of electroacupuncture as an analgestic for laparotomies in two dairy cows.

Electroacupuncture was used as the sole analgesic for standing laparotomies on 2 Friesian cows. Needles placed in the lumbosacral space, and second lumbar interspinous space and high in the lumbar fossa were stimulated with an AC current at 15 to 28 Hz. The analgesia produced was similar to that of a paralumbar nerve block.

Abdomen↗
PubMed1978

Microleakage.

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Composite Resins↗