PubMed Health⌕ Search

Biomedical subjects

S S Wijesinha

Publications and source records attributed to S S Wijesinha.

13 recordsLinked to original sources
PubMed2001

Urinary tract infection. Are we getting it right?

BACKGROUND: A lack of strict diagnostic criteria often leads to overtreatment of inconsequential infection in the urinary tract and inadequate concern for potentially serious infections. OBJECTIVE: To assist in the identification of patients with bacteria in the urinary tract who need to have antibiotic therapy and further imaging investigations. DISCUSSION: Since the majority of urine infections are treated in general practice, much more research is needed on this topic within the general practice environment.

Anti-Bacterial Agents↗
PubMed1998

Does circumcision alter the periurethral bacterial flora?

A prospective study of 25 boys who underwent circumcision for medical reason was performed. Specimens of periurethral bacterial flora were taken before operation as well as 3 weeks after surgery, so that each boy acted as his own control. Before circumcision, 13 (52%) harboured uropathogenic organisms (Escherichia coli and other coliforms, Enterococcus spp, Proteus spp, Pseudomonas spp, and Klebsiella spp); after circumcision, none of the boys had uropathogens, the only organisms cultured from the periurethral region being skin commensals. We postulate that circumcision converts a 'cul-de-sac' that is a reservoir of organisms capable of causing ascending urinary tract infection into a surface colonised by natural skin organisms. This study provides circumstantial evidence supporting the idea that circumcision in well-selected patients may confer protection from urine infection.

Bacteria↗
PubMed1989

Operation for calcaneus deformity after surgery for club foot.

We describe three patients who developed gross calcaneus deformity following surgery for talipes equinovarus. One also had an associated valgus deformity and another had supination of the forefoot; all had intractable problems with footwear. Operation for transfer of the tibialis anterior to the heel, with correction of the associated deformities, was successful and improved both their gait and the shoe problems.

Adolescent↗
PubMed1982

Studies of the immunoglobulin-producing cells of the human intestine: the defunctioned bowel.

An indirect immunoperoxidase method was used to visualise immunoglobulin-containing cells in the large intestinal mucosa of 10 children who had defunctioning colostomies. Intestine deprived of its usual exposure to intraluminal antigens contained less immunocytes per unit area than intestinal mucosa subjected to normal stimulation by dietary and microbial antigens. These findings substantiate in man the conclusion based on observations made on animals that continued mucosal exposure to antigenic stimulation is necessary for the existence of an adequate population of intestinal immunocytes.

Adolescent↗
PubMed1982

Neonatal necrotising enterocolitis: new thoughts for the 'eighties.

Neonatal necrotising enterocolitis has become one of the commonest abdominal emergencies seen by the paediatric surgeon. Historical aspects of the condition and current ideas regarding its pathogenesis are described. An immunological basis for the disease is suggested by its relative rarity in regions where breast feeding is widespread and by recent research work on the intestinal immune system. A new theory about the aetiology of the disease, stressing not a specific pathogen but rather the concept of defective intestinal immunity, is postulated.

Breast Feeding↗
PubMed1979

Evaluation of dextran with local anaesthesia for short-stay inguinal herniorraphy.

A prospective randomised study of 40 patients undergoing unilateral inguinal herniorrhaphy under local anaesthesia was undertaken. Half the patients received the local anaesthetic (0.25% bupivacaine) mixed with dextran 40 solution. Subjective and objective assessments were made of the postoperative pain experienced in the first 48 h after operation. The use of 0.25% bupivacaine local inguinal block results in a postoperative pain-free period of approximately 10 h. Simple oral analgesics are adequate for postoperative pain relief in 87.5% of patients and are required relatively infrequently. The addition of dextran 40 to the local anaesthetic has no significant effect on its duration of action.

Adult↗
PubMedDate not supplied

Observations on the immunocytes and macrophages in megacolon.

An immunoperoxidase staining method was used to study specific immunoglobulin-containing cells in the intestinal mucosa of children who presented with features suggestive of Hirschsprung's disease. No evidence was found to substantiate the hypothesis of an immunologic component in the etiology of Hirschsprung's disease. The megacolon in this condition had an increased proportion of IgG-containing cells and a reduced proportion of IgA-containing cells when compared with normal and unobstructed colon; this may be a reflection of an abnormal mucosal immune defense leading to susceptibility to the enterocolitis found in Hirschsprung's disease. Numerous lipofuscin-bearing macrophages were seen in the colonic mucosa of children with anal stenosis who were given anthraquinone laxatives for varying periods. The possibility that this represents an early stage of melanosis coli, as well as the likelihood of anthraquinones contributing to the pathogenesis of acquired megacolon, are considered.

Animals↗